Journal Highlights

*The following is a selection of published papers. For specific research papers/research results, please check each laboratory’s website.

2024

High-tech tracking technology streamlines drug discovery

Laboratory of Single Molecule Biology
Polyploidy mitigates the impact of DNA damage while simultaneously bearing its burden

Laboratory of Ploidy Pathology
Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy
CheB localizes to polar receptor arrays during repellent adaptation

Laboratory of Nano-Biophysics
Reconstruction of artificial nuclei with nuclear import activity in living mouse oocytes
Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery

Protonic NanoMachine Group
The RNA helicase DDX39 contributes to the nuclear export of spliceosomal U snRNA by loading of PHAX onto RNA

RNA Biofunction Laboratory
HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis

Germline Biology Group
Decision uncertainty as a context for motor memory
Periportal macrophages protect against commensal-driven liver inflammation

Laboratory of Immunology and Cell Biology
HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence

Laboratory of Intracellular Membrane Dynamics

Journal Highlights

2024

High-tech tracking technology streamlines drug discovery

Polyploidy mitigates the impact of DNA damage while simultaneously bearing its burden

Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy

CheB localizes to polar receptor arrays during repellent adaptation

Reconstruction of artificial nuclei with nuclear import activity in living mouse oocytes

Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery

The RNA helicase DDX39 contributes to the nuclear export of spliceosomal U snRNA by loading of PHAX onto RNA

HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis

Decision uncertainty as a context for motor memory

Periportal macrophages protect against commensal-driven liver inflammation

HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence

2023

Pib2 is a cysteine sensor involved in TORC1 activation in Saccharomyces cerevisiae

Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways

Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons

Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging

The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps

Two-dimensional heavy fermion in monoatomic-layer Kondo lattice YbCu2

Nascent ribosomal RNA act as surfactant that suppresses growth of fibrillar centers in nucleolus

Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells

Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as membraneless organelles

Reciprocal connections between parvalbumin-expressing 1 cells and adjacent 2 pyramidal cells are regulated by clustered protocadherin gamma

Cycles of goal silencing and reactivation underlie complex problem-solving in primate frontal and parietal cortex

Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell non-autonomous autophagic and peroxidase activity

Visualization of trans homophilic interaction of clustered protocadherin in neurons

The protein protectors of fertility

Satellite RNAs: emerging players in subnuclear architecture and gene regulation

Ear today, gone tomorrow? A new discovery in a cause of inner-ear bone loss

miRNA/siRNA-directed Pathway to Produce Non-coding piRNAs from Endogenous Protein-coding Regions Ensures Drosophila Spermatogenesis

Unraveling the Mystery of Semi-extractable RNAs From Human Cell Lines

Structures of a FtsZ single protofilament and a double-helical tube in complex with a monobody

Pulling its weight: the protein key to chromosome movement during cell division

CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice

Can humans 'Sniff out' the secrets to the sense of smell?

Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

Correlation between neural responses and human perception in figure-ground segregation

The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2

A cooperation between mitochondria and the endoplasmic reticulum is crucial for the mitochondrial health care system called mitophagy

In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma

2022

Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality

CTCF loss induces giant lamellar bodies in Purkinje cell dendrites

A guide to membraneless organelles and their various roles in gene regulation

Breakdown of bulk-projected isotropy in surface electronic states of topological Kondo insulator SmB6(001)

The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery

Identification of CUL4A- DDB1-WDFY1 as the E3 ubiquitin ligase complex to initiate lysophagy

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron

You trust a face like yours

PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice

Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus

Rec8 cohesin-mediated axis-loop chromatin architecture is required for meiotic recombination

Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response

Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis

Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo

HP1 maintains protein stability of H3K9 methyltransferases and demethylases

Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions

Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase

Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis

Involvement of denervated midbrain-derived factors in the formation of ectopic cortico-mesencephalic projection after hemispherectomy

2021

Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry

A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis

Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function

Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke

Structure of the molecular bushing of the bacterial flagellar motor

Pivot burrowing of scarab beetle (Trypoxylus dichotomus) larva

Native flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries

m6A-modification of HSATIII lncRNAs regulates temperature-dependent splicing

Planar cell polarity induces local microtubule bundling for coordinated ciliary beating

Membrane voltage-dependent activation mechanism of the bacterial flagellar protein export apparatus

Paraspeckles are constructed as block copolymer micelles

Self-face activates the dopamine reward pathway without awareness

SLPI is a critical mediator that controls PTH-induced bone formation

Split conformation of Chaetomium thermophilum Hsp104 disaggregase

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

Two distinct conformations in 34 FliF subunits generate three different symmetries within the flagellar MS-ring

Two-dimensional heavy fermion in monoatomic-layer Kondo lattice YbCu₂

Ebf3⁺ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells

Breakdown of bulk-projected isotropy in surface electronic states of topological Kondo insulator SmB₆(001)

m⁶A-modification of HSATIII lncRNAs regulates temperature-dependent splicing

Single-molecule imaging of PI(4,5)P₂ and PTEN in vitro reveals a positive feedback mechanism for PTEN membrane binding

Relaxation dynamics of [Re(CO)₂(bpy){P(OEt)₃}₂](PF₆) in TEOA solvent measured by time-resolved attenuated total reflection terahertz spectroscopy

Na⁺-induced structural transition of MotPS for stator assembly of the Bacillus flagellar motor