研究セミナー Cortical contractility, from temporal dynamics to structural organization

講演	François ROBIN［Group leader, Developmental Biology Laboratory, Institute for Biology Paris-Seine, CNRS/Inserm/Sorbonne University］
日時	2023年5月23日（火）16:00-17:00
場所	生命システム棟2階セミナー室
言語	英語
世話人	橋本秀彦（1細胞神経生物学研究室・助教） Tel: 06-6105-5708 E-mail: h.hashimoto.fbs[at]osaka-u.ac.jp

要旨

In this seminar, I will discuss two aspects of the contractility of actomyosin networks in the early C. elegans embryo: temporal dynamics and structural organization.
In biological systems, signaling networks propagate and shape extracellular and intracellular inputs. Using single-molecule microscopy, I will show, quantitatively, how the dynamic range of myosin recruitment is tuned by an upstream cascade. Using super-resolution microscopy and single-molecule microscopy, I will then show that how network architecture contributes to actomyosin contractility in the early C. elegans embryo.

参考文献

1) Vlad Costache et al., Rapid assembly of a polar network architecture drives efficient actomyosin contractility, (2022) Cell Reports 31-39(9)
2) Jonathan B Michaux et al., Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo, (2018) Journal of Cell Biol 3-217(12)
3) François ROBIN et al., Single-molecule analysis of cell surface dynamics in Caenorhabditis elegans embryos, (2014) Nature Methods 11, 677–682

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