Research seminars Cortical contractility, from temporal dynamics to structural organization
| Seminar or Lecture |
François ROBIN [Group leader, Developmental Biology Laboratory, Institute for Biology Paris-Seine, CNRS/Inserm/Sorbonne University] |
|---|---|
| Date and Time | 23 May 2023 (Tue), 16:00-17:00 |
| Place | 2F Seminar Room, BioSystems Building |
| Language | English |
| Contact |
Hidehiko Hashimoto (Assistant Professor, Laboratory for Single-cell Neurobiology) |
Abstract
In this seminar, I will discuss two aspects of the contractility of actomyosin networks in the early C. elegans embryo: temporal dynamics and structural organization.
In biological systems, signaling networks propagate and shape extracellular and intracellular inputs. Using single-molecule microscopy, I will show, quantitatively, how the dynamic range of myosin recruitment is tuned by an upstream cascade. Using super-resolution microscopy and single-molecule microscopy, I will then show that how network architecture contributes to actomyosin contractility in the early C. elegans embryo.
References
1) Vlad Costache et al., Rapid assembly of a polar network architecture drives efficient actomyosin contractility, (2022) Cell Reports 31-39(9)2) Jonathan B Michaux et al., Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo, (2018) Journal of Cell Biol 3-217(12)
3) François ROBIN et al., Single-molecule analysis of cell surface dynamics in Caenorhabditis elegans embryos, (2014) Nature Methods 11, 677–682
No registration is required.
