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Integrated Biology Laboratories

Laboratory of Cancer Pathology

Prof. INOUE Daichi Prof. INOUE Daichi

Keywords：

Cancer, Leukemia, Post-transcriptional regulation, Single cell analysis, Metabolism, Chromatin, Treatment of diseases

Knowing Cancer, Knowing Yourself, and Knowing How to Fight Cancer

Join us in Osaka to face "Cancer". Our laboratory is dedicated to unraveling the mechanism that separates cancer from normal cells through multilevel analysis of human data, animal models, and single cells, and we are even applying this vulnerability to therapeutic applications. For example, we are pioneering groundbreaking research by capturing the phenomenon of genetic information distortion at the RNA level in Cancer. In 2024, we aim to become the "most OMOROI" cancer research laboratory by fusion development that transcends the boundaries between basic and clinical medicine.

Where Do Cancer Cells Come From? What Are They? Where Are They Going? Understanding of unrecognized mechanisms and therapeutic applications based on the pathophysiology of cancer. (Some images are from TogoTV)

Members

Prof. INOUE Daichi d-inoue[at]patho.med.osaka-u.ac.jp
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Q＆A

What is your hot research topic?
There are mainly two aspects: capturing "the vulnerability of cancer cells" from the perspectives of RNA biology and metabolism, and developing technology to understand the spatiotemporal "origin and fate of cells."
Have you had any breakthroughs or significant research progress in the last 5 years?
The unrecognized mechanism of cancer, traditionally attributed to the rewriting of information at the DNA level, has been elucidated through new analytical methods using clinical specimens and mouse models, revealing distortions in genetic information at the RNA level. Additionally, deepening our understanding of the cells surrounding cancer at the single-cell level has led to a significant increase in the resolution of cancer research.
What kind of background do your lab members have?
We have a diverse range of participants, including MDs (medical doctors), non-MD researchers, Chinese, those aspiring to become academic researchers, and those aiming for employment in industries.
Do you collaborate with other institutions and universities?
I utilize my network from my time studying in the United States to foster close collaborations with researchers in the U.S. and various universities and research institutions in Japan.
How do you develop your research?
We aim to understand the vulnerabilities of cancer cells and the mechanisms behind cancer development from new perspectives, connecting them to the comprehension of novel pathologies and their application in innovative treatments.

Research Highlights

Publications (Research Articles, Reviews, Books)

2023

Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro, Tomokatsu Ikawa, Hiromi Yamazaki, Miki Fukumoto, Atsushi Tanaka, Yasutaka Hayashi, Yui Koike, Yumi Aoyama, Hiromi Ito, Hiroyoshi Nishikawa, Toshio Kitamura, Akinori Kanai, Akihiko Yokoyama, Tohru Fujiwara, Susumu Goyama, Hideki Noguchi, Stanley C. Lee, Atsushi Toyoda, Kunihiko Hinohara, Omar Abdel-Wahab & Daichi Inoue

BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state

Nat Commun. 14(1):8372  2023 （PMID：38102116 DOI：10.1038/s41467-023-44081-6）

Atsushi Tanaka, Koutarou Nishimura, Wataru Saika, Ayana Kon, Yui Koike, Hiromi Tatsumi, June Takeda, Masaki Nomura, Weijia Zang, Manabu Nakayama, Masashi Matsuda, Hiromi Yamazaki, Miki Fukumoto, Hiromi Ito, Yasutaka Hayashi, Toshio Kitamura, Hiroshi Kawamoto, Akifumi Takaori-Kondo, Haruhiko Koseki, Seishi Ogawa & Daichi Inoue

SETBP1 is dispensable for normal and malignant hematopoiesis

Leukemia. 37(9):1802-1811  2023 （PMID：37464069 DOI：10.1038/s41375-023-01970-5）

2022

Yasutaka Hayashi, Kimihito C Kawabata, Yosuke Tanaka, Yasufumi Uehara, Yo Mabuchi, Koichi Murakami, Akira Nishiyama, Shigeru Kiryu, Yusuke Yoshioka, Yasunori Ota, Tatsuki Sugiyama, Keiko Mikami, Moe Tamura, Tsuyoshi Fukushima, Shuhei Asada, Reina Takeda, Yuya Kunisaki, Tomofusa Fukuyama, Kazuaki Yokoyama, Tomoyuki Uchida, Masao Hagihara, Nobuhiro Ohno, Kensuke Usuki, Arinobu Tojo, Yoshio Katayama, Susumu Goyama, Fumio Arai, Tomohiko Tamura, Takashi Nagasawa, Takahiro Ochiya, Daichi Inoue, Toshio Kitamura

MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis

Cell Rep. 39(6):110805  2022 （PMID：35545056 DOI：10.1016/j.celrep.2022.110805）

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

Blood. 140(8):875-888  2022 （PMID：35709354 DOI：10.1182/blood.2021015325）

2021

Daichi Inoue, Jacob T. Polaski, Justin Taylor, Pau Castel, Sisi Chen, Susumu Kobayashi, Simon J. Hogg, Yasutaka Hayashi, Jose Mario Bello Pineda, Ettaib El Marabti, Caroline Erickson, Katherine Knorr, Miki Fukumoto, Hiromi Yamazaki, Atsushi Tanaka, Chie Fukui, Sydney X. Lu, Benjamin H. Durham, Bo Liu, Eric Wang, Sanjoy Mehta, Daniel Zakheim, Ralph Garippa, Alex Penson, …Omar Abdel-Wahab

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Nat Genetics. 53(5):707-718  2021 （PMID：33846634 DOI：10.1038/s41588-021-00828-9）

2019

Daichi Inoue, Guo-Liang Chew, Bo Liu, Brittany C. Michel, Joseph Pangallo, Andrew R. D’Avino, Tyler Hitchman, Khrystyna North, Stanley Chun-Wei Lee, Lillian Bitner, Ariele Block, Amanda R. Moore, Akihide Yoshimi, Luisa Escobar-Hoyos, Hana Cho, Alex Penson, Sydney X. Lu, Justin Taylor, Yu Chen, Cigall Kadoch, Omar Abdel-Wahab & Robert K. Bradley

Spliceosomal disruption of the non-canonical BAF complex in cancer

Nature. 574(7778):432-436  2019 （PMID：31597964 DOI：10.1038/s41586-019-1646-9）

Our ideal candidate (as a graduate student)

If you have a passion for cancer research, you are more than welcome to join us.

Contact

Laboratory of Cancer Pathology, Graduate School of Frontier Biosciences, Osaka University,
2-2 Yamadaoka, Suita, Osaka 565-0871 Japan.
E-mail: d-inoue[at]patho.med.osaka-u.ac.jp (Prof. Daichi Inoue)

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