Integrated Biology Laboratories
Laboratory of Cancer Pathology
Keywords:
Cancer, Leukemia, Post-transcriptional regulation, Single cell analysis, Metabolism, Chromatin, Treatment of diseases
Knowing Cancer, Knowing Yourself, and Knowing How to Fight Cancer
Where Do Cancer Cells Come From? What Are They? Where Are They Going? Understanding of unrecognized mechanisms and therapeutic applications based on the pathophysiology of cancer. (Some images are from TogoTV)
Members
Prof. INOUE Daichi | d-inoue[at]patho.med.osaka-u.ac.jp |
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Q&A
- What is your hot research topic?
- There are mainly two aspects: capturing "the vulnerability of cancer cells" from the perspectives of RNA biology and metabolism, and developing technology to understand the spatiotemporal "origin and fate of cells."
- Have you had any breakthroughs or significant research progress in the last 5 years?
- The unrecognized mechanism of cancer, traditionally attributed to the rewriting of information at the DNA level, has been elucidated through new analytical methods using clinical specimens and mouse models, revealing distortions in genetic information at the RNA level. Additionally, deepening our understanding of the cells surrounding cancer at the single-cell level has led to a significant increase in the resolution of cancer research.
- What kind of background do your lab members have?
- We have a diverse range of participants, including MDs (medical doctors), non-MD researchers, Chinese, those aspiring to become academic researchers, and those aiming for employment in industries.
- Do you collaborate with other institutions and universities?
- I utilize my network from my time studying in the United States to foster close collaborations with researchers in the U.S. and various universities and research institutions in Japan.
- How do you develop your research?
- We aim to understand the vulnerabilities of cancer cells and the mechanisms behind cancer development from new perspectives, connecting them to the comprehension of novel pathologies and their application in innovative treatments.
Research Highlights
Publications (Research Articles, Reviews, Books)
2023
BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state
Nat Commun. 14(1):8372 2023 (PMID:38102116 DOI:10.1038/s41467-023-44081-6)
SETBP1 is dispensable for normal and malignant hematopoiesis
Leukemia. 37(9):1802-1811 2023 (PMID:37464069 DOI:10.1038/s41375-023-01970-5)
2022
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis
Cell Rep. 39(6):110805 2022 (PMID:35545056 DOI:10.1016/j.celrep.2022.110805)
Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia
Blood. 140(8):875-888 2022 (PMID:35709354 DOI:10.1182/blood.2021015325)
2021
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition
Nat Genetics. 53(5):707-718 2021 (PMID:33846634 DOI:10.1038/s41588-021-00828-9)
2019
Spliceosomal disruption of the non-canonical BAF complex in cancer
Nature. 574(7778):432-436 2019 (PMID:31597964 DOI:10.1038/s41586-019-1646-9)
Our ideal candidate (as a graduate student)
If you have a passion for cancer research, you are more than welcome to join us.
Contact
Laboratory of Cancer Pathology, Graduate School of Frontier Biosciences, Osaka University,
2-2 Yamadaoka, Suita, Osaka 565-0871 Japan.
E-mail: d-inoue[at]patho.med.osaka-u.ac.jp (Prof. Daichi Inoue)
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