Integrated Biology Laboratories
Laboratory for Stem Cell Homeostasis
Skin, Hair follicle stem cells, Homeostasis, Live imaging, Single cell omics
Elucidate the basic principles of the stem cell-based homeostatic system which maintains our bodies
The tissues and organs in our body are a cellular society composed of a wide variety of cells. Homeostasis of their structure and function is maintained by regulating the balance between self-renewal and differentiation of tissue stem cells, replenishing lost differentiated and damaged cells daily. Using skin and hair follicles as models, we will elucidate how the stem cell-based homeostatic system is emergent during development and understand the basic principles of the development of the multicellular system.
Development of hair follicles and the underlying stem cell system
Lineage analysis using the long-term live imaging of hair follicle development
|Assoc. Prof. MORITA Ritsuko
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- What is your hot research topic?
- The basis of the homeostatic system of tissue stem cells is generated during morphogenesis and is thought to be inherited after birth; however, the process of how and when the homeostatic system is established is still unclear. We aim to clarify the mechanisms for the establishment and initiation of the homeostatic system by focusing on the transitions of stem cells and organs from the embryonic stage (morphogenesis) to the adult stage (homeostasis).
- Have you had any breakthroughs or significant research progress in the recent years?
- Recently we identified the developmental origin of hair follicle stem cells by combining two comprehensive and unbiased single-cell methods: lineage analysis using the long-term live imaging of hair follicle development and time-course single-cell transcriptomes. Furthermore, we also proposed a "telescope model" to explain the mechanism of coordinated constituent cell fate determination and hair follicle development.
- Do you collaborate with other institutions and universities?
- We work closely with RIKEN to conduct basic research.
- How do you develop your research?
- We will understand the establishment of the homeostatic system in skin and hair follicles and develop new technologies to apply our results to research and medical fields.
- What kind of background do your lab members have？
- As this is a newly established laboratory, we are currently recruiting members. We welcome everyone with any background, expertise, or major.
- What kind of careers do your Lab's alumni go on to?
- As this is a newly established laboratory, we hope many students will become leaders in the fields they pursue in the future.
Publications (Research Articles, Reviews, Books)
Tracing the developmental origin of tissue stem cells.
Dev Growth Differ. 64(9):566-576 2022
Tracing the origin of hair follicle stem cells.
Nature 594: 547_552 2021
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.
Nature commun. 12(1):2577 2021
Multi-tasking epidermal stem cells: Beyond epidermal maintenance.
Dev Growth Differ. 60(9):531-541 2018
Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations.
PLoS One. 11(9):e0161336 2016
Our ideal candidate (as a graduate student)
We are looking for highly motivated people to work on our research topics. Our lab welcomes people who love living things, enjoy delicate work with their hands, and creating things. We welcome everyone with any background, expertise, or major.
In our laboratory, we will conduct research using a variety of advanced technologies, including live imaging, single cell genomics, and gene editing technology. If you love challenges and want to explore with intellectual curiosity, please contact us.
Let’s enjoy science and take advantage of the research environment offered by the Graduate School of Frontier Biosciences.
Laboratory for Stem Cell Homeostasis, Graduate School of Frontier Biosciences, Osaka University,
1-3 Yamadaoka, Suita, Osaka 565-0871 Japan.
TEL: +81-6-6105-5240 (Assoc. Prof. MORITA Ritsuko)
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