Organismal Biosystems Laboratories
Laboratory of Tissue Biochemistry
Prof. TSUMAKI Noriyuki
Keywords：
Cartilage, Cell differentiation, Extracellular matrix, Regenerative medicine, iPS cell, Orthopaedic surgery
Investigate skeletal biology and develop treatment for cartilage diseases.
The treatment of these cartilage diseases is difficult and has been a challenging area of research for many years.
In our laboratory, we are attempting to elucidate the pathogenesis of cartilage diseases by investigating the mechanisms that control cartilage formation and differentiation using biochemistry, molecular biology, and histology techniques.
We are also working on the development of new cartilage regeneration therapies and drug discoveries using iPS cell technology.
Articular cartilage covers the ends of bones and is responsible for smooth movements, and its damage or degeneration causes mobility impairment. Growth cartilage promotes bone growth and its dysfunction causes shortening and deformation of the skeleton. We are investigating mechanisms that regulate skeletal formation to develop curative treatments for these intractable cartilage diseases.
Members
| TSUMAKI Noriyuki (Professor) | ntsumaki〔at〕tsu.med.osaka-u.ac.jp |
|---|---|
| YAMASHITA Akihiro（Assistant Professor) | |
| HORIKE Nanao（Assistant Professor) | |
| ABE Kengo（Assistant Professor) | |
| SHIMA Nobuyuki（Specially Appointed Assistant Professor） | |
| NEGISHI Takahiro（Specially Appointed Assistant Professor） | |
| TAZUMI Atutoshi(Specially Appointed Assistant Professor) | |
| MORIOKA Miho（Specially Appointed Researcher) | |
| KOYAMATSU Saeko(Specially Appointed Researcher) | |
| HATADA Ryousuke(Specially Appointed Researcher) | |
| KAMIYA Tadasuke(Joint Research Collaborator) | |
| MATSUDA Chieko(Specially Appointed Technical Stuff) | |
| OTA Chie(Specially Appointed Technical Stuff) | |
| KATO Tomoko（Specially Appointed Technical Stuff) | |
| KISHIDA Aoi (Specially Appointed Technical Stuff) | |
| TANAKA Noriko(Technical Stuff) | |
| HAMADA Humiko(Technical Stuff) | |
| EZAKI Akihiro(Graduate Student) | |
| MUTO Atsuko (Secretary) |
You could probably reach more information of individual researchers by Research Map and researcher's search of Osaka-U.
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Q＆A
- What is your hot research topic?
- Investigating mechanisms of chondrocyte differentiation by mobilizing biochemistry, molecular biology, histology, and next-generation sequencing technologies.
- Have you had any breakthroughs or significant research progress in the last 5 years?
- Clinical research has begun on regenerative medicine, in which cartilage tissue created from iPS cells is transplanted into damaged knee joint cartilage.
- What kind of background do your lab members have？
- We have a diverse group of members with backgrounds in medicine, dentistry, science, pharmaceutical science, and nutrition.
- Do you collaborate with other institutions and universities?
- We work closely with the Kyoto University iPS Cell Research Institute to conduct basic research and clinical applications.
- What kind of careers do your Lab's alumni go on to?
- Researchers in universities and corporate R&D facilities, research technicians
- How do you develop your research?
- We will elucidate mechanisms of chondrocyte differentiation at the molecular level and develop new therapeutic methods for cartilage diseases by targeting the molecules identified.
Research Highlights
Publications (Research Articles, Reviews, Books)
2023
Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone
Frontiers in Cell and Developmental Biology 11151947 2023 （PMID：37255604 DOI：10.3389/fcell.2023.1151947）
Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect doi: https://doi.org/10.1038/s41467-023-36408-0
Nature Communications 804 2023 （PMID：36808132 DOI：doi: https://doi.org/10.1038/s41467-023-36408-0）
2022
Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus
Biomaterials 121491 2022 （PMID：35395453 DOI：https://doi.org/10.1016/j.biomaterials.2022.121491）
2021
Generation of Monkey Induced Pluripotent Stem Cell-Derived Cartilage Lacking Major Histocompatibility Complex Class I Molecules on the Cell Surface
Tissue Eng. Part A 2021 （PMID：34182799 DOI：10.1089/ten.TEA.2021.0053）
Implantation of human iPS cell-derived cartilage in bone defects of mice.
Tissue Eng. Part A 2021 （PMID：33567995 DOI：10.1089/ten.TEA.2020.0346）
2020
Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia.
Sci Rep 10(1):20915 2020 （PMID：33262386 DOI：10.1038/s41598-020-77345-y）
Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells.
Stem Cells Transl. Med. 10(1):115-127 2020 （PMID：32822104 DOI：10.1002/sctm.20-0058）
Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage.
Sci Rep 30;10(1):12794 2020 （PMID：32732907 DOI：10.1038/s41598-020-69641-4）
2019
Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation.
Biochem. Biophys. Res. Commun. 516(4):1097-1102 2019 （PMID：31280862 DOI：10.1016/j.bbrc.2019.06.139）
Our ideal candidate (as a graduate student)
We are looking for highly motivated people with a genuine interest in our research to work in our lab who work well with others. All academic backgrounds, expertise, and majors/fields of study are welcome.
Contact
Laboratory of Tissue Biochemistry, Graduate School of Frontier Biosciences, Osaka University,
2-2 Yamadaoka, Suita, Osaka 565-0871 Japan.
TSUMAKI Noriyuki (Professor)
info[at]tsu.med.osaka-u.ac.jp
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