FBS Colloquia No.408Laboratory of Ploidy Pathology

Exploration of novel cancer therapeutic targets focusing on the characteristics of polyploid cells

Polyploidization (whole genome doubling) is frequently observed in solid tumors. Polyploid cancers exhibit pronounced chromosomal instability and are generally associated with high aggressiveness and poor prognosis. However, despite advances in genome-based precision medicine, no selective therapeutic strategies targeting polyploid cancers have yet been established. As a novel therapeutic approach for polyploid cancers and tumors with high chromosomal instability, considerable efforts have focused on the development of treatments targeting the regulatory mechanisms of chromosome segregation. In contrast, our laboratory is pursuing a different strategy by elucidating the intrinsic characteristics of polyploid cells and aiming to develop therapeutic approaches that exploit their specific vulnerabilities. In this colloquium, I will present recent findings from our research, focusing on alterations in cellular behavior and the molecular pathophysiology associated with polyploid cancer cells.