FBS Colloquia No.379Laboratory of Ploidy Pathology

Seminar or Lecture	The Impact of Ploidy Alterations on Cancer Evolution Tomonori Matsumoto [Associate Professor, Laboratory of Ploidy Pathology]
Date and Time	4 Mar. 2025 (Tue), 12:15～13:00
Place	2F Seminar Room, BioSystems Building
Language	Japanese
Contact	Tomonori Matsumoto (Associate Professor) E-mail: matsumoto.tomonori.fbs[at]osaka-u.ac.jp TEL: 06-6105-5243

The Impact of Ploidy Alterations on Cancer Evolution

Mammals, including humans, are diploid organisms, but polyploid cells with duplicated genomes are frequently observed in tissue damage and cancer. Polyploidization has been suggested to drive malignant evolution in cancer cells and contribute to the development of treatment-resistant cancers. Our laboratory has shown that polyploidization not only doubles the genome but also exerts various effects on subsequent cancer cell behavior through analyses using cultured cells, mouse models, and clinical specimens. In this colloquium, I will discuss insights from our recent research on how changes in ploidy impact cancer cell behavior and the pathological features of cancer.