FBS Colloquia No.367Laboratory of Cancer Pathology

Unraveling the Mechanisms of Aberrant Post-Transcriptional Regulation in Cancer

To better understand the complex nature of cancer and its treatment targets, we need methods beyond traditional approaches. By combining data-driven techniques, like CRISPR-based screening, with analyzing clinical samples and using classical models, we have discovered unexpected mechanisms behind cancer development. For example, in cancer cells, the genetic information at the RNA level can become distorted, causing essential genes to lose or change their functions. This opens up new possibilities for treatments based on this new understanding of pathology. Our previous research has shown that abnormal RNA splicing can lead to alterations in signaling pathways, chromatin structure, and transcription factors, which disrupts stem cell transcription programs and contributes to cancer (Inoue et al., Nature 2019; Inoue et al., Nature Genetics 2021; Tanaka et al., Blood 2022; Xiao et al., Nat Commun 2023). In this presentation, we will share our efforts to better understand "Cancer Pathology" and explore new treatment applications, blending both traditional and modern approaches.