FBS Colloquia No.363Laboratory of Epigenome Dynamics

Identifying Interaction Proteins of Transcription/Epigenetic Factors in Sex Differentiation

In mammals, XY chromosomes typically indicate male sex, while XX indicates female. The Sry gene on the Y chromosome activates the gene network for testis differentiation during fetal development, promoting male characteristics. If Sry's activity is insufficient, XY individuals can develop ovaries and become female. Our lab studies the mechanisms of sex differentiation from epigenomic and metabolic perspectives. Recently, proximity-dependent biotin labeling (BioID) has emerged as a popular method for analyzing protein interactions. In this seminar, we will present and discuss our findings using BioID to explore the interactors of transcription factors and epigenetic regulators involved in sex differentiation.