FBS Colloquia No.338Laboratory of Chromosome Biology
| Seminar or Lecture |
Molecular basis for dynamic regulation of centromere/kinetochore molecular architecture Mariko Ariyoshi [Specially Appointed Assistant Professor, Laboratory of Chromosome Biology] |
|---|---|
| Date and Time | 17 Oct. 2023 (Tue), 12:15～13:00 |
| Place | 2F Seminar Room, BioSystems Building |
| Language | Japanese |
| Contact |
Tetsuya Hori (Associate Professor) |
Molecular basis for dynamic regulation of centromere/kinetochore molecular architecture
Chromosome segregation is a fundamental process during cell division, by which replicated chromosomes are equally distributed into two daughter cells and genomic information is faithfully inherited to next generation. The centromere is an essential genome region for accurate chromosome segregation in eukaryotes. A critical epigenetic marker for centromere specification is a nucleosome containing a histone H3 variant CENP-A (CENP-A nucleosome). Once the centromere position is defined by the CENP-A nucleosome, a multiprotein complex, termed kinetochore is assembled on the centromere, and links between the centromeric chromosome and spindle microtubules during mitosis. The assembly of a functional kinetochore on the centromere facilitates faithful chromosome segregation. In chicken cells, two kinetochore-related proteins, CENP-C and KNL2 have been found to directly bind to the CENP-A nucleosome. Our recent structural and functional studies of CENP-C and KNL2 have provided new insights into plasticity of the inner kinetochore, which is key to understand temporal and spatial regulation mechanisms of chromosome segregation through the kinetochore.
