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FBS Colloquia No.317Laboratory of Stem Cell Biology and Developmental Immunology

Seminar or Lecture

Molecular basis of cellular niches for hematopoietic stem cells in bone marrow

Yoshiki Omatsu [Associate Professor, FBS, Laboratory of Stem Cell Biology and Developmental Immunology]

Date and Time 15 Dec. 2022 (Thu), 12:15~13:00
Place 2F Seminar Room, BioSystems Building
Language Japanese
Contact

Yoshiki Omatsu (Associate Professor)
E-mail: omatsu[at]fbs.osaka-u.ac.jp
TEL: EXT. 7968

Molecular basis of cellular niches for hematopoietic stem cells in bone marrow

The special microenvironment, termed niche, with which hematopoietic stem cells (HSCs) are in contact, has been thought to be required for the maintenance of HSCs and the generation of blood cells and immune cells in the bone marrow. Although the identity of the HSC niche has been a subject of long-standing debate, recent studies demonstrated that a population of mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, are the pivotal cellular components of HSC niche. And we revealed that CAR cells express several specific transcription factors essential for their development and functions. In this colloquium, I would like to introduce our series of studies, focused on the roles of these transcription factors in CAR cells.

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