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FBS Colloquia No.316Laboratory for Embryogenesis

Seminar or Lecture

Elimination mechanisms of abnormal cells at the onset of epiblast formation

Masakazu Hashimoto [Associate Professor, Lab. for embryology (Sasaki Lab)]

Date and Time 8 Dec. 2022 (Thu), 12:15~13:00
Place 2F Seminar Room, BioSystems Building and Online (Zoom)
Language Japanese
Contact

Masakazu Hashimoto (Associate Professor)
E-mail:mhashimo[at]fbs.osaka-u.ac.jp
TEL:06-6879-4659

Elimination mechanisms of abnormal cells at the onset of epiblast formation

Epiblast is the pluripotent tissue, which is the origin of all cells in the mammalian embryo and is established in the preimplantation stage. The cell number of epiblast at the onset of its formation is quite small (approximately 10 cells), therefore any abnormal cells (e.g., low pluripotency) should not be included in epiblast to support the normal later development and postnatal healthy life. However, the mechanisms of the high-quality epiblast formation have been enigmatic. Recently, we found that low pluripotent (abnormal) cells are competitively eliminated by higher pluripotent cells in epiblast (Hashimoto and Sasaki, Dev. Cell 2019). In this seminar, I will introduce our current study on the elimination mechanisms of the abnormal cells in the early-stage mouse embryo.

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