FBS Colloquia No.278RNA Biofunction Laboratory

Multifunctionality of primate-specific HSATIII lncRNAs

HSATIII lncRNAs are primate-specific transcripts mostly consisting of GGAAU repeat. HSATIII lncRNAs are transcribed under thermal stress conditions and stably remain in the nucleus, where they recruit specific RNA-binding proteins (RBPs) to assemble massive membraneless subnuclear structures called nuclear stress bodies (nSBs). Recently, we reported that nSBs repress splicing of hundreds of specific pre-mRNAs during thermal stress recovery through the dual control mechanisms. We also introduce an unexpected additional function of HSATIII lncRNAs in cytoplasm.