FBS Colloquia No.243Laboratory of Epigenome Dynamics
| Seminar or Lecture |
Two exon-type Sry is essential for mouse male development MIYAWAKI Shingo [Laboratory of Epigenome Dynamics] |
|---|---|
| Date and Time | 2 July 2020 (Thu), 12:15-13:00 |
| Place | Online (Zoom) | An email will be sent with the meeting URL, ID, and password on the morning of each colloquium. |
| Language | Japanese |
| Contact |
Shunsuke Kuroki |
Two exon-type Sry is essential for mouse male development
The mammalian sex-determining gene Sry induces male development. Since its discovery 30 years ago, Sry has been believed to be a single-exon. Here, we identified a cryptic second exon of mouse Sry and a corresponding novel transcript, two-exon Sry (Sry-T). XY mice lacking Sry-T were sex-reversed, and ectopic expression of Sry-T in XX mice induced male development. Our findings suggest that Sry-T is necessary and sufficient in mouse male development. I will introduce recent progress on the studies of Sry exon2 and Sry-T.
