FBS Colloquia No.242Nuclear Dynamics Group

Seminar or Lecture	Phase separation drives pairing of homologous chromosomes HIRAOKA Yasushi [Nuclear Dynamics Group]
Date and Time	25 June 2020 (Thu), 12:15-13:00
Place	Online (Zoom) \| An email will be sent with the meeting URL, ID, and password on the morning of each colloquium.
Language	Japanese
Contact	Haruhiko Asakawa Tel: 06-6879-4621 E-mail: askw[at]fbs.osaka-u.ac.jp

Phase separation drives pairing of homologous chromosomes

Pairing of homologous chromosomes is crucial for ensuring accurate segregation of chromosomes during meiosis. Molecular mechanisms of homologous chromosome pairing in meiosis have been extensively studied in the fission yeast Schizosaccharomyces pombe. In this organism, meiosis-specific noncoding RNA transcribed from specific genes accumulates at the respective gene loci during pairing of homologous chromosomes. Recent studies have demonstrated that chromosome-associated RNA-protein complexes mediate meiotic pairing of homologous loci through phase separation.