FBS Colloquia No.241Laboratory of Medical Biochemistry
| Seminar or Lecture |
Mechanical loadings induce BNP gene expression via the stress-responsive enhancer CR9 MATSUOKA Ken [Laboratory of Medical Biochemistry] |
|---|---|
| Date and Time | 18 June 2020 (Thu), 12:15-13:00 |
| Place | Online (Zoom) | An email will be sent with the meeting URL, ID, and password on the morning of each colloquium. |
| Language | Japanese |
| Contact |
Osamu Tsukamoto |
Mechanical loadings induce BNP gene expression via the stress-responsive enhancer CR9
Brain natriuretic peptide (BNP), encoded by the Nppb gene, is a well-known biomarker that is strongly induced during heart failure and represents its severity. Cardiologists frequently use these peptides as natriuretic and vasorelaxant agents to treat various clinical conditions. We identified 650bp of heart-failure responsive enhancer (CR9) inducing BNP gene expression in the previous study. In the transgenic mouse, in which the CR9 enhancer and the luciferase reporter gene are introduced, CR9 activated the reporter gene in a cardiac specific manner during the progression of heart failure. However, the regulatory mechanism of CR9 remains unknown. We aimed to elucidate pathophysiological factors and pathways that trigger to activate the CR9 enhancer.
