FBS Colloquia No.224Laboratory of Intracellular Membrane Dynamics
| Seminar or Lecture |
Novel transcriptional mechanism regulating autophagy in cellular senescence Hitomi Imoto [Graduate School of Medicine] Identification and characterization of novel autophagy factors; Rubicon, PLEKHM1 and AGPAT Keisuke Tabata [Laboratory of Intracellular Membrane Dynamics] |
|---|---|
| Date and Time | Thursday, Oct. 3, 2019, 12:15-13:00 |
| Place | 2F Seminar Room, BioSystems Building |
| Language | Japanese |
| Contact |
Maho Hamasaki |
Novel transcriptional mechanism regulating autophagy in cellular senescence
Aging correlates with reduced autophagy, and autophagic impairment is associated with onset of age-related disease. Although the accumulation of senescent cells affects the organismal aging and the prevalence of age-related disease, the knowledge regarding roles of autophagy in cellular senescence is still limited. To identify a pathway that can coordinate autophagy in cellular senescence, we focused on a transcription factor which has been reported to promote longevity through autophagic pathway in C. elegans. In my presentation we will discuss updated mechanistic insight of this transcription factor and role of autophagy in cellular senescence.
Identification and characterization of novel autophagy factors; Rubicon, PLEKHM1 and AGPAT
Autophagy allows the orderly degradation and recycling of damaged cellular organelles or cytoplasmic material via content engulfment within double membrane vesicles called autophagosome. Autophagy can be activated by cellular stresses such as starvation and provides the cell with energy during times of energy depletion. In addition, the selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Discovery of autophagy-related (ATG) genes has enabled the analysis of autophagosome formation in detail. However, how autophagosome is generated and regulated remains still largely unclear. In this seminar, I would like to talk about the roles of three regulators, Rubicon, PLEKHM1and AGPAT in autophagy.
