FBS Colloquia No.214Institute for Protein Research
| Seminar or Lecture |
Structure of the tripartite efflux pump MexAB-OprM spanning two membranes Eiki Yamashita [Institute for Protein Research] |
|---|---|
| Date and Time | Thursday, June 20, 2019, 12:15-13:00 |
| Place | 2F Seminar Room, BioSystems Building |
| Language | Japanese |
| Contact |
Atsushi Nakagawa |
Structure of the tripartite efflux pump MexAB-OprM spanning two membranes
Tripartite efflux pumps play a major role in multidrug resistance in Gram-negative bacteria. The MexAB-OprM efflux pump, which is constitutively expressed, contributes to intrinsic resistance of Pseudomonas aeruginosa to various antimicrobials. Recently, we determined the whole structure of MexAB-OprM. In this colloquium, I will present the suggested mechanisms for complex formation and drug efflux on the basis of the structure.
