Research seminars Decision making of dormancy breaking in fission yeast: exploring mechanisms how sleeping cells wake up

Dormant cells (e.g., spores of fission yeast) sense changes of surrounding environment, which somehow leads to dormancy breaking to enter division cycles. To understand the underlying mechanisms, we employed a multi-NGS approach comprising single-cell RNA-seq (Tsuyuzaki et al. Nature communications 2020) and chromatin ATAC-seq and found that histone is a key for dormancy breaking. In combination with our preliminary observations regarding autophagy, we would like to discuss how cells break dormancy.