Research seminars Dynamin Prime – why synapses operate so fast
| Seminar or Lecture |
Yuuta Imoto, Ph.D. [Research Associate, Johns Hopkins University School of Medicine, Baltimore, MD, USA] |
|---|---|
| Date and Time | 19 Sep. 2023 (Tue), 16:00-17:00 |
| Place | 2F Seminar Room, BioSystems Building |
| Language | English |
| Contact |
Koji Okamoto |
Synaptic vesicle endocytosis generates vesicles as quickly as 100 ms following neurotransmitter release. However, given this rapid time scale, molecular mechanism has been unclear. We have recently demonstrated that a subsynaptic structure, called 'Dynamin Prime', can mediate this rapid process. Superresolution microscopy and single molecule tracking showed Dynamin Prime is localized at endocytic zone. This structure is maintained through multivalent interactions among different endocytic proteins, including the brain-enriched GTPase dynamin variant Dyn1xA and the BAR domain protein Syndapin1. Disruption of multivalent interactions results in diffuse endocytic proteins and a ~100-fold decrease in endocytic kinetics. Thus, this study may end the long-standing debate on how neurons rapidly recycle synaptic vesicles.
No registration is required.
This is a credit recognition seminar for the Master’s and Doctor’s Degree Programs of Graduate School of Frontier Biosciences.
No registration is required.
This is a credit recognition seminar for the Master’s and Doctor’s Degree Programs of Graduate School of Frontier Biosciences.
