FBS Colloquia No.323Laboratory of Tissue Biochemistry

Seminar or Lecture	Regeneration of the intervertebral disc using iPSC-derived cartilaginous tissue Hiroki Hagizawa [4th year students of the doctoral course, Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University]
Date and Time	9 May 2023 (Tue), 12:15～13:00
Place	Online (Zoom) \| An email will be sent with the meeting URL, ID, and password to all FBS members.
Language	Japanese
Contact	Akihiro Yamashita (Assistant Professor) E-mail: akihiro.yamashita[at]tsu.med.osaka-u.ac.jp

Regeneration of the intervertebral disc using iPSC-derived cartilaginous tissue

Many people have complaints of low back pain, and one of the causes of this back pain is intervertebral discs (IVDs) degeneration. IVDs are located between the vertebrae and help give the spinal column its flexibility and act as shock absorbers between vertebrae. The degeneration of IVDs is caused by degeneration of the nucleus pulposus which is located in center of the IVD. In this study, we demonstrated the efficacy of iPSC-derived cartilaginous tissue using a nude rat implantation model. In addition, we investigated the changes before and after implantation by single-cell RNA sequencing (scRNA-seq) analysis.