FBS Colloquia No.277Laboratory of Epigenome Dynamics

Seminar or Lecture	Mechanism of HP1-mediated heterochromatin formation in mammalian cells Ryo Maeda [Project assistant professor, Laboratory of Epigenome Dynamics]
Date and Time	9 Sep. 2021 (Thu), 12:15～13:00
Place	Online (Zoom) \| An email will be sent with the meeting URL, ID, and password to all FBS members.
Language	Japanese
Contact	Shunsuke Kuroki Tel: 06-6879-4672 E-mail: skuroki[at]fbs.osaka-u.ac.jp

Mechanism of HP1-mediated heterochromatin formation in mammalian cells

Histone H3 lysine 9 (H3K9) methylation is an epigenetic mark for transcriptionally repressed chromatin. Previous studies revealed that H3K9 methylation is not statically but dynamically regulated during mammalian development. However, this molecular mechanism remains unclear. We recently found that H3K9 methylation binding protein HP1 is essential for maintaining H3K9 methylation. In this seminar, I would like to introduce the mechanism of heterochromatin formation in mammalian cells.