NEWS
- 2025.03.10
- Dispath has been published in Curr Biol
- 2024.11.01
- Paper has been published in iScience
- 2023.06.08
- Paper has been published in Mol. Cell
How are chromosomes inherited
to the next generation during cell division?
All the genetic information (genome) of living organisms is packed into structures called chromosomes, which are inherited to the next generation of cells. Therefore, the correct inheritance of chromosomes is essential for the maintenance of life. It is also known that problems in chromosome inheritance can cause abnormalities in chromosome structure, leading to many diseases, including cancer. Therefore, we would like to elucidate the mechanism of "how chromosomes are inherited to the next generation?
What we aim
to achieve in our lab
We are focusing on chromosome segregation in chromosome inheritance. In particular, we focus on the function and structure of centromeres and kinetochores formed on chromosomes and aim to elucidate the molecular mechanism of accurate chromosome segregation
Elucidating how chromosomes are accurately segregated to the next generation of cells will lead to an understanding of the basic principles that sustain life and contribute to the elucidation of the pathogenic mechanisms of diseases caused by chromosome aberrations and to drug discovery.
Research Approach
Molecular biology, Cell biology, Biochemistry,
Structural Biology, Genome Biology,
and Chromosome Engineering
- Generation of mutant cells for kinetochore protein using cultured cells
- Functional analysis of kinetochore proteins using mutant cells
- Structural biology of the kinetochore protein complex
- Understanding centromere chromatin using genome biology
- Creation of artificial kinetochores using chromosome engineering
- Evolutionary conservation and diversity of Centromere/Kinetochores
Join us in tackling the mysteries of chromosomes in one of the top research environments in the world
We welcome those who are interested in our research and have a strong desire to do research, those who love living things, and those who enjoy detailed manual work and manufacturing. We are looking for energetic people with rich ideas.
Who is a good fit
for our lab
- People who are interested in cellular and molecular biology using cultured cells
- People who want to conduct research that combines microscopy and biochemistry
- People who are interested in structural biology
- People who are interested in basic cancer research
- People who are interested
in chromosomes and genome dynamics。 - People who want
to devote themselves
to some research
