発表論文
#:corresponding author
- 2023
- Tsukita,K., Kitamata,M., Kashihara,H., Yano,T., Fujiwara,I., F Day,T., Katsuno,T., Kim,J., Takenaga,F., Tanaka,H., Park,S., Miyata,M., Watanabe,H., Kondoh,G., Takahashi,R., #Tamura,A., and #Tsukita,S. 2023. Phase separation of an acitn nucleator by junctional microtubules regulates epithelial function. Science Adv. 9: eadf6358. https://doi.org/10.1126/sciadv.adf6358
- Eisenstein, F., Yanagisawa, H., Kashihara, H., Kikkawa, M., Tsukita, S., and #Danev, R. 2023.Parallel cryo electron tomography on in situ lamellae. Nature Methods 20:130-138. https://doi.org/10.1038/s41592-022-01690-1
- Suzuki,K., Yamaga,K., Tokumasu,R., Katsuno,T., Tanaka,H., Chiba,S., Yagi,T., Katayama,I., Tamura,A., Murota,H., and #Tsukita,S. 2023.Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice. Ann NY Acad Sci. 1523:51-61. https://doi.org/10.1111/nyas.14980
- Sugiyama, S., #Sasaki, T., Tanaka, H., Yan, H., Ikegami, T., Kanki, H., Nishiyama, K., Beck, G., Gon, Y., Okazaki, S., Todo, K., Tamura, A., Tsukita, S., and Mochizuki,H. 2023.The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.Sci Rep. 18;13:2892. https://doi.org/10.1038/s41598-023-29894-1
- 2021
- Ozono, Y., #Tamura, A., Nakayama, S., Herawati, E., Hanada, Y., Ohata, K., Takagishi, M., Takahashi, M., Imai, T., Ohta, Y., Oshima, K., Sato, T., Inohara, H., and #Tsukita, S. 2021. Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules. Sci Rep. 11(1):20224. https://doi.org/10.1038/s41598-021-96232-8
- #Kim, J., Tamura, A., Tsukita, S., and #Parl, S. 2021. Uniaxial stretching device for studying maturity-dependent morphological response of epithelial cell monolayers to tensile strain. J Ind Eng Chem. 99: 282- 291. https://doi.org/10.1016/j.jiec.2021.04.036
- Sone, N., Konishi, S., Igura, K., Tamai, K., Ikeo, S., Korogi, Y., Kanagaki, S., Namba, T., Yamamoto, Y., Xu, Y., Takeuchi, K., Adachi, Y., Chen-Yoshikawa, T.F., Date, H., Hagiwara, M., Tsukita, S., Hirai, T., Torisawa, Y., and #Goto, S. 2021. Multicellular Modeling of Ciliopathy by Combining iPS cells and Microfluidic Airway-on-a chip Technology. Sci Transl Med. 13(601):eabb1298. https://doi.org/10.1126/scitranslmed.abb1298
- #Sato, K., Matsumoto, I., Suzuki, K., Kasamatsu, J., Yamamoto, H., Miyasaka, T., Miyahara, A., Zong, T., Kagesawa, T., Oniyama, A., Kawamura, K., Kitai, Y., Umeki, A., Kannno, E., Tanno, H., Ishii, K., Tsukita, S., and Kawakami, K. 2021. Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs. Sci Rep. 11(1):21110. https://doi.org/10.1038/s41598-021-00708-6
- Nakayama, S., Yano, T., Namba, T., Konishi, S., Takagishi, M., Herawati, E., Nishida, T., Imoto, Y., Ishihara, S., Takahashi, M., Furuta, K., Oiwa, K., Tamura, A., and #Tsukita, S. 2021. Planar cell polarity induces local microtubule bundling for coordinated ciliary beating. J Cell Biol. 220(7):e202010034. https://doi.org/10.1083/jcb.202010034
- Yano, T., Tsukita, K., Kanoh, H., Nakayama, S., Kashihara, H., Mizuno, T., Tanaka, H., Matsui, T., Goto, Y., Komatsubara, A., Aoki, K., Takahashi, R., #Tamura, A., and #Tsukita, S. 2021. A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction. EMBO J. 40(2):e104712. https://doi.org/10.15252/embj.2020104712
- 2020
- Matsuo, J., Douchi, D., Myint, K., Mon, NN., Yamamura, A., Kohu, K., Heng, DL., Chen, S., Mawan, NA., Nuttonmanit, N., L,i Y., Srivastava, S., Ho, SWT., Lee, NYS., Lee, HK., Adachi, M., Tamura, A., Chen, J., Yang, H., Teh, M., So, JB., Yong, WP., Tan, P., Yeoh, KG., #Chuang, LSH., #Tsukita, S., and #Ito, Y. 2020. Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. Gut. gutjnl-2020-322779. https://doi.org/10.1136/gutjnl-2020-322779
- Raju, P., Shashikanth, N., Tsai, PY., Pongkorpsakol, P., Chanez-Parades, S., Steinhagen, PR., Kuo, WT., Singh, G., Tsukita, S., and #Turner, JR. 2020. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. J Clin Invest. 130(10):5197-5208. https://doi.org/10.1172/JCI138697
- 2019
- #Tsukita, S., Tanaka, H., and Tamura, A. 2019. The Claudins: From Tight Junctions to Biological Systems. Trends Biochem Sci. 44(2):141-152. https://doi.org/10.1016/j.tibs.2018.09.008
- Nakamura, S., Irie, K., Tanaka, H., Nishikawa, K., Suzuki, H., Saitoh, Y., Tamura, A., Tsukita, S., and #Fujiyoshi, Y. 2019. Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun. 10(1):816. https://doi.org/10.1038/s41467-019-08760-7
- Tsukita, K., Yano, T., Tamura, A., and #Tsukita, S. 2019. Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function? Int J Mol Sci. 20(23):6012. https://doi.org/10.3390/ijms20236012
- Konishi, S., Yano, T., Tanaka, H., Mizuno, T., Kanoh, H., Tsukita, K., Namba, T., Tamura, A., Yonemura, S., Gotoh, S., Matsumoto, H., Hirai, T., and #Tsukita, S. 2019. Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions. Life Sci Alliance. 2(4):e201900414. https://doi.org/10.26508/lsa.201900414
- Ito, C., Akutsu, H., Yao, R., Yoshida, K., Yamatoya, K., Mutoh, T., Makino, T., Aoyama, K., Ishikawa, H., Kunimoto, K., Tsukita, S., Noda, T., Kikkawa, M., and #Toshimori, K. 2019. Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice. Sci Rep. 9(1):14249. https://doi.org/10.1038/s41598-019-50516-2
- Rouaud, F., Vasileva, E., Spadaro, D., Tsukita, S., and #Citi, S. 2019. R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing. Tissue Barriers. 7(3):e1653748. https://doi.org/10.1080/21688370.2019.1653748
- Suzuki, K., Sentani, K., Tanaka, H., Yano, T., Suzuki, K., Oshima, M., Yasui, W., Tamura, A., and #Tsukita, S. 2019. Deficiency of stomach-type claudin-18 in mice induces gastric tumor formation independent of H pylori infection. Cell Mol Gastroenterol Hepatol. 8(1):119-142. https://doi.org/10.1016/j.jcmgh.2019.03.003
- Zha, JM., Li, HS., Lin, Q., Kuo, WT., Jiang, ZH., Tsai, PY., Ding, N., Wu, J., Xu, SF., Wang, YT., Pan, J., Zhou, XM., Chen, K., Tao, M., Odenwald, MA., Tamura, A., Tsukita, S., #Turner, JR., and #He, WQ. 2019. Interleukin 22 expands transit-amplifying cells while depleting Lgr5(+) stem cells via Inhibition of Wnt and Notch signaling. Cell Mol Gastroenterol Hepatol. 7(2):255-274. https://doi.org/10.1016/j.jcmgh.2018.09.006
- Kashihara, H., Chiba, S., Kanno, SI., Suzuki, K., Yano, T., and #Tsukita, S. 2019. Cep128 associates with Odf2 to form the subdistal appendage of the centriole. Genes Cells. 24(3):231-243. https://doi.org/10.1111/gtc.12668
- Tsukita, S., Yano,T., and Herawati, E. 2019. Apical Cytoskeletons help define the barrier functions of epithelial cell sheets in biological systems. Make Life Visible (Springer Open) 31-38. https://doi.org/10.1007/978-981-13-7908-6_4
- 2018
- Yano, T., Torisawa, T., Oiwa, K., and #Tsukita, S. 2018. AMPK-dependent phosphorylation of cingulin reversibly regulates its binding to actin filaments and microtubules. Sci Rep. 8(1):15550. https://doi.org/10.1038/s41598-018-33418-7
- Tanaka, H., Imasato, M., Yamazaki, Y., Matsumoto, K., Kunimoto, K., Delpierre, J., Meyer, K., Zerial, M., Kitamura, N., Watanabe, M., Tamura, A., and #Tsukita ,S. 2018. Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. J Hepatol. 69(6):1308-1316. https://doi.org/10.1016/j.jhep.2018.08.025
- Yamaga, K., Murota, H., Tamura, A., Miyata, H., Ohmi, M., Kikuta, J., Ishii, M., #Tsukita, S., and Katayama, I. 2018. Claudin-3 loss causes leakage of sweat from the sweat gland to contribute to the pathogenesis of atopic dermatitis. J Invest Dermatol. 138(6):1279-1287. https://doi.org/10.1016/j.jid.2017.11.040
- 2017
- Tanaka, H., Tamura, A., Suzuki, K., and #Tsukita, S. 2017. Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism. Ann N Y Acad Sci. 1405(1):44-52. https://doi.org/10.1111/nyas.13438
- Yano, T., Kanoh, H., Tamura, A., and #Tsukita, S. 2017. Apical cytoskeletons and tight junctions as a unified system in epithelial cell sheets. Ann N Y Acad Sci. 1405(1):32-43. https://doi.org/10.1111/nyas.13432
- Tokumasu, R., Tamura, A., and #Tsukita, S. 2017. Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin. Tissue Barriers. 5(3):e1336194. https://doi.org/10.1080/21688370.2017.1336194
- Tsai, P.Y., Zhang, B., He, W.Q., Zha, J.M., Odenwald, M.A., Singh, G., Tamura, A., Shen, L., Sailer, A., Yeruva, S., Kuo, W.T., Fu, Y.X., Tsukita, S., and #Turner, JR. 2017. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. Cell Host Microbe. 21(6):671-681.e4. https://doi.org/10.1016/j.chom.2017.05.009
- #Dunst, J., Azzouz, N., Liu, X., Tsukita, S., Seeberger, P.H., and #Kamena, F. 2017. Interaction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in Malaria pathology. Front Cell Infect Microbiol. 7:183. https://doi.org/10.3389/fcimb.2017.00183
- Tateishi, K., Nishida, T., Inoue, K., and #Tsukita, S. 2017. Three-dimensional organization of layered apical cytoskeletal networks associated with mouse airway tissue development. Sci Rep. 7:43783. https://doi.org/10.1038/srep43783
- Fujimoto, K., Kinoshita, M., Tanaka, H., Okuzaki, D., Shimada, Y., Kayama, H., Okumura, R., Furuta, Y., Narazaki, M., Tamura, A., Hatakeyama, S., Ikawa, M., Tsuchiya, K., Watanabe, M., Kumanogoh, A., Tsukita, S., and #Takeda, K. 2017. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol. 10(2):446-459. https://doi.org/10.1038/mi.2016.58
- Okano, T., Takeuchi, S., Soma, Y., Suzuki, K., Tsukita, S., Ishizu, A., Suzuki, K., and #Kawakami, T. 2017. Presence of anti-phosphatidylserine-prothrombin complex antibodies and anti-moesin antibodies in patients with polyarteritis nodosa. J Dermatol. 44(1):18-22. https://doi.org/10.1111/1346-8138.13491
- 2016
- Herawati, E., Taniguchi, D., Kanoh, H., Tateishi, K., Ishihara, S., and #Tsukita, S. 2016. Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton. J Cell Biol. 214(5):571-86. https://doi.org/10.1083/jcb.201601023
- Tokumasu, R., Yamaga, K., Yamazaki, Y., Murota, H., Suzuki, K., Tamura, A., Bando, K., Furuta, Y., Katayama, I., and #Tsukita, S. 2016. Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 113(28):E4061-8. https://doi.org/10.1073/pnas.1525474113
- #Oneyama, C., Yoshikawa, Y., Ninomiya, Y., Iino, T., Tsukita, S., and Okada, M. 2016. Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression. Oncogene. 35(4):501-12. https://doi.org/10.1038/onc.2015.110
- Konishi, S., #Gotoh, S., Tateishi, K., Yamamoto, Y., Korogi, Y., Nagasaki, T., Matsumoto, H., Muro, S., Hirai, T., Ito, I., Tsukita, S., and Mishima, M. 2016. Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells. Stem Cell Reports. 6(1):18-25. https://doi.org/10.1016/j.stemcr.2015.11.010
- Tanaka, H., Yamamoto, Y., Kashihara, H., Yamazaki, Y., Tani, K., Fujiyoshi, Y., Mineta, K., Takeuchi, K., #Tamura, A., and #Tsukita, S. 2016. Claudin-21 Has a Paracellular Channel Role at Tight Junctions. Mol Cell Biol. 36(6):954-64. https://doi.org/10.1128/MCB.00758-15