original Publication list (1998〜present)

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Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.
Shiratori H, Yashiro K, Iwai N, Oki S, Minegishi K, Ikawa Y, Kanata K, Hamada H.
Dev Biol. 2014 Sep 16.
PMID: 25224222 [PubMed - as supplied by publisher]


Hydrodynamic phase locking in mouse node cilia.

Takamatsu, A.*, Shinohara, K., Ishikawa, T. and Hamada, H. (2013). Physical Review Letters.110:24810


Asymmetric rotational stroke in mouse node cilia during left-right determination. Takamatsu, A.*, Ishikawa, T. Shinohara, K., and Hamada, H. Physical Review E. 87(5-1):050701


Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. Dong F, Shinohara K, Botilde Y, Nabeshima R, Asai Y, Fukumoto A, Hasegawa T, Matsuo M, Takeda H, Shiratori H, Nakamura T,Hamada H.

J Cell Biol. 2014 Jan 20;204(2):203-13. doi: 10.1083/jcb.201304076. Epub 2014 Jan 13.PMID:24421334

  • EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.Lei Z, Maeda T, Tamura A, Nakamura T, Yamazaki Y, Shiratori H, Yashiro K, Tsukita S, Hamada H.Dev Biol. 2012 Jul 17.PMID:22819673
  • Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway.Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y.Dev Cell. 2012 Jun 12;22(6):1163-75.PMID:22698281
  • Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet.Kunimoto K, Yamazaki Y, Nishida T, Shinohara K, Ishikawa H, Hasegawa T, Okanoue T, Hamada H, Noda T, Tamura A, Tsukita S, Tsukita S. Cell. 2012 Jan 20;148(1-2):189-200.PMID:22265411
  • Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.Shinohara K, Kawasumi A, Takamatsu A, Yoshiba S, Botilde Y, Motoyama N, Reith W, Durand B, Shiratori H, Hamada H.Nat Commun. 2012 Jan 10;3:622. 
  • Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo. Takaoka K, Yamamoto M, Hamada H. Nat Cell Biol. 2011 May 29.
  • SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Probst S, Kraemer C, Demougin P, Sheth R, Martin GR, Shiratori H, Hamada H, Iber D, Zeller R, Zuniga A. Development. 2011 May;138(10):1913-23. Epub 2011 Apr 6
  • Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos.ng. Kawasumi A, Nakamura T, Iwai N, Yashiro K, Saijoh Y, Shiratori H, Hamada H Dev. Biol. 2011 Mar 23
  • Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. Lopes Floro K, Artap ST, Preis JI, Fatkin D, Chapman G, Furtado MB, Harvey RP, Hamada H, Sparrow DB, Dunwoodie SL. Hum Mol Genet. 2011 Mar 15;20(6):1097-110. Epub 2010 Dec 28.
  • Characterization of Pitx2c expression in the mouse heart using a reporter transgene. Furtado MB, Biben C, Shiratori H, Hamada H, Harvey RP. Dev Dyn. 2011 Jan;240(1):195-203.
  • An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. Cell. 2007 Mar 9;128(5):947-59
  • Planar polarization of node cells determines the rotational axis of node cilia. Hashimoto M, Shinohara K, Wang J, Ikeuchi S, Yoshiba S, Meno C, Nonaka S, Takada S, Hatta K, Wynshaw-Boris A, Hamada H. Nat Cell Biol. 2010 Feb;12(2):170-6.
  • Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Uehara M, Yashiro K, Takaoka K, Yamamoto M,Hamada H. Genes Dev. 2009 Jul 15;23(14):1689-98.
  • Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H. Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo. J Cell Biol. 2009 Jan 26;184(2):323-34.
  • Tanaka C, Sakuma R, Nakamura T, Hamada H , Saijoh Y. Long-range action of Nodal requires interaction with GDF1. Genes Dev. 2007 Dec 15;21(24):3272-82.
  • Yashiro K, Shiratori H, Hamada H. Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch. Nature. 2007 Nov 8;450(7167):285-8.
  • Oki S, Hashimoto R, Okui Y, Shen MM, Mekada E, Otani H, Saijoh Y, Hamada H. . Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development. 2007 Nov;134(21):3893-904. Epub 2007 Oct 3.
  • Nakamura T, Mine N, Nakaguchi E, Mochizuki A, Yamamoto M, Yashiro K, Meno C, Hamada H. Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system. Dev Cell. 2006 Oct;11(4):495-504.
  • Shiratori H, Yashiro K, Shen MM, Hamada H. Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development. 2006 Aug;133(15):3015-25.
  • Bowles J, Knight D, Smith C, Wilhelm D, Richman J, Mamiya S, Yashiro K, Chawengsaksophak K, Wilson MJ, Rossant J,Hamada H, Koopman P. Retinoid signaling determines germ cell fate in mice. Science. 2006 Apr 28;312(5773):596-600. Epub 2006 Mar 30.
  • Takaoka K, Yamamoto M, Shiratori H, Meno C, Rossant J, Saijoh Y,Hamada H. Related Articles, Links The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Dev Cell. 2006 Apr;10(4):451-9.
  • Kobayashi S, Isotani A, Mise N, Yamamoto M, Fujihara Y, Kaseda K, Nakanishi T, Ikawa M, Hamada H, Abe K, Okabe M. Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. Curr Biol. 2006 Jan 24;16(2):166-72.
  • Nonaka S, Yoshiba S, Watanabe D, Ikeuchi S, Goto T, Marshall WF, Hamada H. De novo formation of left-right asymmetry by posterior tilt of nodal cilia. PLoS Biol. 2005 Aug;3(8):e268. Epub 2005 Jul 26.
  • Saijoh Y, Oki S, Tanaka C, Nakamura T, Adachi H, Yan YT, Shen MM, Hamada H. (2005)Two nodal-responsive enhancers control left-right asymmetric expression of Nodal. Dev Dyn. 2005 Apr;232(4):1031-6.
  • Nishino J, Yamashita K, Hashiguchi H, Fujii H, Shimazaki T, Hamada H.(2004) Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. EMBO J. 2004 May 5;23(9):1998-2008.
  • Yamamoto M, Saijoh Y, Perea-Gomez A, Shawlot W, Behringer RR, Ang SL, Hamada H, Meno C.(2004) Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Nature. 428(6981):387-92
  • Yashiro K, Zhao X, Uehara M, Yamashita K, Nishijima M, Nishino J, Saijoh Y, Sakai Y, Hamada H. (2004)Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell. 6(3):411-22.
  • Hou J, Yashiro K, Okazaki Y, Saijoh Y, Hayashizaki Y, Hamada H.(2004) Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily. Dev Dyn. 2004 Feb;229(2):373-9.
  • Yamamoto M, Mine N, Mochida K, Sakai Y, Saijoh Y, Meno C, Hamada H.(2003) Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate Development. 130(9):1795-1804
  • Saijoh Y, Oki S, Ohishi S, Hamada H.(2003)Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72.
  • Watanabe D, Saijoh Y, Nonaka S, Sasaki G, Ikawa Y, Yokoyama T, Hamada H.(2003) The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia Development. 130(9):1725-1734
  • Perea-Gomez A, Vella FD, Shawlot W, Oulad-Abdelghani M, Chazaud C, Meno C, Pfister V, Chen L, Robertson E, Hamada H, Behringer RR, Ang SL. (2002) Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks Dev Cell. 3(5):745-756
  • Nonaka S, Shiratori H, Saijoh Y, Hamada H.(2002) Determination of left-right patterning of the mouse embryo by artificial nodal flow Nature. 418:96-99
  • Sakuma R, Ohnishi Yi Y, Meno C, Fujii H, Juan H, Takeuchi J, Ogura T, Li E, Miyazono K, Hamada H.(2002) Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.Genes Cell. 7(4):401-412
  • Meno C, Takeuchi J, Sakuma R, Koshiba-Takeuchi K, Ohishi S, Saijoh Y, Miyazaki J, ten Dijke P, Ogura T, Hamada H.(2001) Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2 Dev. Cell 1(1):127-138
  • Yamamoto, M., Meno, C., Sakai, Y., Shiratori, H., Mochida, K., Ikawa, Y., Saijoh, Y., and Hamada, H. (2001) A transcription factor FoxH1/FAST mediates Nodal signaling during anterio-posterior patterning and node formation in the mouse.Genes & Dev. 15:1242-56.
  • Sakai, Y., Meno, C., Nishino, J., Shiratori, H., Saijoh, Y., Rossant, J. and Hamada, H. (2001). CYP26/P450RA, a retinoic acid-inactivating enzyme, is required for establishing an uneven distribution of retinoic acid along the anteroposterior axis within the mouse embyro. Genes & Dev. 15: 213-225.
  • Shiratori, H., Sakuma, R., Watanabe, M., Hashiguchi, H., Mochida, K., Nishino, J., Sakai, Y., Saijoh, Y., Whitman, M. and Hamada, H.(2001). Two step regulation of asymmetric Pitx2 expression: Initiation by Nodal signaling and maintenance by Nkx2. Mol. Cell 7:137-149.
  • Ishimaru, Y., Yoshioka, H., Tao, H., Thisse, B., Thisse, C., Wright, C.V.E., Hamada, H., Ohuchi, H., and Noji, S. (2000). Asymmetric expression of antivin/lefty1 in the early chick embryo. Mech. Dev. 90:115-118.
  • Osada, S., Saijoh, Y., Frisch, A., Yeo, C.-Y., Adachi, H., Watanabe, M., Whitman, M., Hamada, H., Wright, C.V. (2000). Activin/Nodal responsiveness and asymmetric expression of Xenopus nodal-related gene converge on a FAST-regulated module in intron 1. Development. 127:2503-2514.
  • Yashiro, K., Saijoh, Y., Sakuma, R., Sakai, Y., Tomita, N., Matsuda, Y., Okada, S. Monden, M. and Hamada, H. (2000). Distinct transcriptional regulation and phylogenetic diversity of human LEFTY genes. Genes Cell. 5:343-357.
  • Saijoh, Y., Adachi, H., Sakuma, R., Yeo, C.-Y., Yashiro, K., Watanabe, M., Hashiguchi, H., Yashiro, K., Kawabata, M., Miyazono, K., Whitman, M. and Hamada, H. (2000). Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes a transcription factor FAST2. Mol. Cell 5:35-47.
  • Okada, Y., Nonaka, S., Tanaka, Y., Saijoh, Y., Hamada, H., and Hirokawa, N. (1999). Abnormal nodal flow precedes situs inversus in iv and inv mutant mice. Mol. Cell 4:459-468.
  • Meno, C.*, Gritmann, K.*, Ohfuji, Y., Heckscher, E., Ohishi, S., Mochida, K., Shimono, A., Kondoh, H., Talbot, W., Robertson, E.J., Schier, A. and Hamada, H. (1999). Mouse Lefty2 and zebrafish Antivin are feedback inhibitors of Nodal signaling during vertebrate gastrulation. (* equally contributed) Mol. Cell 4: 287-298.
  • Adachi, H., Saijoh, Y. Mochida, K., Ohishi, S., Hashiguchi, H., Hirao, A., and Hamada, H. (1999) Determination of left-right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty2 enhancer. Genes Dev. 13:1589-1600.
  • Saijoh, Y., Adachi, H., Mochida, K., Ohishi, S.,Hirao, A., and Hamada, H. (1999) Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty1 and lefty2. Genes & Dev. 13:259-269.
  • Mochizuki, T., Saijoh, Y.,Tsuchiya, K., Shirayoshi, Y., Takai, S., Taya, C., Yonekawa, H., Yamada, K., Nihei, H., Nakatsuji, N., Overbeek, P., Hamada, H., and Yokoyama, T. (1998). Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature 395:177-181.
  • Hagino-Yamagishi, K., Saijoh, Y., Yamazaki, Y., Yazaki, K., and Hamada, H. (1998). Transcriptional regulaory region of Brn-2 required for the expression in olfactory epithelial cells. Dev. Brain Res. 109, 77-89.

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