Top > members > Takayuki Ariga
Self introduction
Takayuki ARIGA, Ph.D
Graduate School of Frontier Biosciences, Osaka University, Associate professor
Email: ariga.fbs _at_ osaka-u.ac.jp
My old email address (ariga_at_yamaguchi-u.ac.jp) no longer exists.
See Reserchmap in detail.
Japanese page is here. (日本語のページ）
Research
We are researching
(1) Nonequilibrium energetics of biomolecular motors by using single-molecule manipulation and
(2) Mechanobiology to measure the mechanical properties of cells and tissues.
Our goal is to discover new physics in living organisms through manipulation and measurement on multiple levels,
from single molecules to organs.
Nonequilibrium energetics of biomolecular motors by using single-molecule manipulation
with optical tweezers (Click to enlarge)
We are studying Energetics of a biomolecular motor, kinesin, by using a single-molecule manipulation microscope (right figure) combined with optical tweezers.
Recently, we found that kinesin can accelerate by using non-equiliburium, external force fluctuations.
Check out the following NEWS articles for our latest researches.
・APS Physics "Low Efficiency Spotted in a Molecular Motor" (November 21, 2018)
・APS Physics "Continuous Jostling Helps Protein Perform" (October 22, 2021) ←NEW!!
Related Publications:
・T. Ariga*, M. Tomishige, D. Mizuno, Phys. Rev. Lett. 121, 218101 (2018) DOI, arXiv
・有賀 隆行, 富重 道雄, 水野 大介, 生物物理 59,300-304 (2019) DOI
・T. Ariga*, M. Tomishige, D. Mizuno, Biophys. Rev. 12, 503-510 (2020) DOI (Review)
・T. Ariga*, K. Tateishi, M. Tomishige, D. Mizuno, Phys. Rev. Lett. 127, 178101 (2021)
DOI, arXiv
・有賀 隆行, 「非熱的なゆらぎで加速する分子モーター」特集 『揺らぎが奏でる生命機能』, 細胞, 55, 8-11 (2023).
Publisher
・有賀 隆行, 富重 道雄, 水野 大介, 「非熱的なゆらぎが分子モーターキネシンを加速させる」生物物理 63,86-90 (2023) DOI
・T. Ariga* "Nonthermal fluctuations accelerate biomolecular motors" Biophys. Rev. *, *-* (2024) DOI (Review) ←NEW!! (Open Access)
Mechanobiology to measure the mechanical properties of cells and tissues.
(Click to enlarge)
In collaboration with Mizuno Lab. at Kyushu University, we measured the mechanical properties of the cells and found that the inside of the cells fluctuated violently.
In collaboration with Seiki Lab.at Yamaguchi University, we are developping a recently established measurement method by using ferrofluid oil droplets to measure mechanical properties of organs/tissues (right figure).
Related Publications:
・K. Nishizawa, M. Bremerich, H. Ayade, C. F. Schmidt, T. Ariga, D. Mizuno, Science Advances, 3, e1700318 (2017)
DOI
・K. Nishizawa, N. Honda, S. Inokuchi, H. Ebata, T. Ariga, D. Mizuno, Physical Review E , 108, 034601 (2023)
DOI ←NEW!!
Lectures
Under construction...(See Japanese page)
Links
Collaborators
・Systems Biochemistry in Pathology and Regeneration, Yamaguchi University
・Mizuno Laboratory, Kyushu University
・Tomishige Laboratory, Aoyama Gakuin University (Japanese)
・Hayashi Laboratory, The University of Tokyo
・Okamoto Laboratory, Nara Women's University
・Assistant Professor YOKOYAMA Takeshi
Grants (excerpts)
・JST-CREST, Elucidating the Power of Life through Innovative Measurement and Analysis Techniques ←NEW!!
・JST-PREST, Dynamic supra-assembly of biomolecular systems
・Molecular Engine
・Information physics of living matters
・Nakatani Foundation