2023.9.12
9月17日にJohns Hopkins University の井元裕太氏をお招きし、FBSセミナー タイトル”Dynamin Prime – why synapses operate so fast”を開催します
FBS Seminar 2023
”Dynamin Prime – why synapses operate so fast”
講演：井元 祐太 博士（リサーチアソシエイト, ジョンズホプキンス大学医学部, ボルチモア, メリーランド州, アメリカ合衆国）
日時: 2023年9月19日（火）16:00-17:00
場所: 生命システム棟２F セミナー室
言語: 英語
世話人: 岡本 浩二（生命機能研究科・ミトコンドリア動態学研究室）
Tel: 06-6879-7970
E-mail: okamoto.koji.fbs[at]osaka-u.ac.jp
Synaptic vesicle endocytosis generates vesicles as quickly as 100 ms following neurotransmitter release. However, given this rapid time scale, molecular mechanism has been unclear. We have recently demonstrated that a subsynaptic structure, called 'Dynamin Prime', can mediate this rapid process. Superresolution microscopy and single molecule tracking showed Dynamin Prime is localized at endocytic zone. This structure is maintained through multivalent interactions among different endocytic proteins, including the brain-enriched GTPase dynamin variant Dyn1xA and the BAR domain protein Syndapin1. Disruption of multivalent interactions results in diffuse endocytic proteins and a ~100-fold decrease in endocytic kinetics. Thus, this study may end the long-standing debate on how neurons rapidly recycle synaptic vesicles.
”Dynamin Prime – why synapses operate so fast”
講演：井元 祐太 博士（リサーチアソシエイト, ジョンズホプキンス大学医学部, ボルチモア, メリーランド州, アメリカ合衆国）
日時: 2023年9月19日（火）16:00-17:00
場所: 生命システム棟２F セミナー室
言語: 英語
世話人: 岡本 浩二（生命機能研究科・ミトコンドリア動態学研究室）
Tel: 06-6879-7970
E-mail: okamoto.koji.fbs[at]osaka-u.ac.jp
Synaptic vesicle endocytosis generates vesicles as quickly as 100 ms following neurotransmitter release. However, given this rapid time scale, molecular mechanism has been unclear. We have recently demonstrated that a subsynaptic structure, called 'Dynamin Prime', can mediate this rapid process. Superresolution microscopy and single molecule tracking showed Dynamin Prime is localized at endocytic zone. This structure is maintained through multivalent interactions among different endocytic proteins, including the brain-enriched GTPase dynamin variant Dyn1xA and the BAR domain protein Syndapin1. Disruption of multivalent interactions results in diffuse endocytic proteins and a ~100-fold decrease in endocytic kinetics. Thus, this study may end the long-standing debate on how neurons rapidly recycle synaptic vesicles.
