Research seminars How cells deploy autophagy to fight against bacteria
| Seminar or Lecture |
Felix Randow [Research Leader, MRC Laboratory of Molecular Biology, Cambridge, UK] |
|---|---|
| Date and Time | 7 Nov. 2023 (Tue), 16:00-17:00 |
| Place | 3F Seminar Room, Nanobiology Building |
| Contact |
Tamotsu Yoshimori (Professor, Laboratory of Intracellular Membrane Dynamics) |
Abstract
Intracellular pathogens colonize specific subcellular niches determined by their requirement for host-derived nutrients and antagonized by compartment-specific immunity. Most intracellular bacteria dwell in phagosomes and only few species have succeeded in conquering the cytosol, a perhaps counterintuitive situation given the abundance of nutrients freely available in the cytosol. Potent cytosolic defense mechanisms must therefore exist. I will discuss how cells defend their cytosol against bacterial invasion through autophagy as we have discovered novel triggers for anti-bacterial autophagy, namely the detection of sphingomyelin on damaged phagosomes by TECPR1 and the ubiquitylation of LPS on Gram-negative bacteria by RNF213.
