大阪大学大学院 生命機能研究科 ミトコンドリア動態学研究室 ©2013 N. & K. Okamoto. All rights reserved. 禁無断転載

成果発表・活動
原著論文

25. Eiyama, A., Kondo-Okamoto, N., and Okamoto, K. (2013). Mitochondrial degradation during starvation is selective and temporally distinct from bulk autophagy in yeast. FEBS Lett., in press.


24. Kondo-Okamoto, N., Noda N.N., Suzuki, S.W., Nakatogawa, H., Takahashi, I., Matsunami, M., Hashimoto, A., Inagaki, F., Ohsumi, Y., Okamoto, K. (2012). Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy. J. Biol. Chem., 287, 10631-10638.


23. Koshiba, T., Holman, H.A., Kubara, K., Yasukawa, K., Kawabata, S., Okamoto, K., MacFarlane, J., Shaw, J.M. (2011). Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: implications for mitochondrial inheritance. J. Biol. Chem., 286, 354-362.


22. Okamoto, K.*, Kondo-Okamoto, N., and Ohsumi, Y.* (2009). Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev. Cell, 17: 87–97. *Corresponding authors.


21. Kondo-Okamoto, N., Shaw, J.M., and Okamoto, K.* (2008). TPR proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. EMBO rep., 9: 63-69. *Corresponding author.


20. Frederick, R.L., Okamoto, K., and Shaw, J.M. (2008). Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics, 178: 825-837.


19. Kondo-Okamoto, N., Ohkuni, K., Kitagawa, K., McCaffery, J.M., Shaw, J.M.*, and Okamoto, K.* (2006). The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Mol. Biol. Cell, 17: 3756-3767. *Corresponding authors.


18. Frederick, R.L., McCaffery, J.M., Cunningham K.W., Okamoto, K.*, and Shaw, J.M.* (2004). Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J. Cell Biol., 167: 87-98. *Corresponding authors.


17. Sekito, T., Okamoto, K., Kitano, H., and Yoshida, K. (2004). Up-to-dating of complete sequenced DNA data of Hansenula wingei yeast mitochondria. Nucleic Acids Symp. Ser., 48: 179-180.


16. Stojanovski, D., Koutsopoulos, O.S., Okamoto, K., and Ryan, M.T. (2004). Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J. Cell Sci., 117: 1201-1210.


15. Kondo-Okamoto, N., Shaw, J.M.*, and Okamoto, K.* (2003). Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. J. Biol. Chem., 278: 48997-49005. *Corresponding authors.


14. Okamoto, K., Brinker, A., Paschen, S.A., Moarefi, I., Hayer-Hartl, M., Neupert, W., and Brunner, M. (2002). The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation. EMBO J., 21: 3659-3671.


13. Moro, F., Okamoto, K., Donzeau, M., Neupert, W., and Brunner, M. (2002). Mitochondrial protein import: molecular basis of the ATP-dependent interaction of mtHsp70 with Tim44. J. Biol. Chem., 277: 6874-6880.


12. MacAlpine, D.M., Kolesar, J., Okamoto, K., Butow, R.A., and Perlman, P.S. (2001). Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA. EMBO J., 20: 1807-1817.


11. Okamoto, K., Perlman, P.S., and Butow, R.A. (1998). The sorting of mitochondrial DNA and mitochondrial proteins in zygotes: preferential transmission of mitochondrial DNA to the medial bud. J. Cell Biol., 142: 613-623.


10. Zelenaya-Troitskaya, O., Newman, S.M., Okamoto, K., Perlman, P.S., and Butow, R.A. (1998). Function of the HMG box protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics, 148: 1763-1776.


9.  Okamoto, K., Sekito, T., and Yoshida, K. (1996). The secondary structure and phylogenetic relationship deduced from complete nucleotide sequence of mitochondrial small subunit rRNA in yeast Hansenula wingei. Genes Genet. Syst., 71: 69-74.


8.  Yoshida, K., Okamoto, K., and Sekito, T. (1996). Is the evolution of mitochondrial genes independent from that of the corresponding nuclear genes in fungi? Construction of molecular phylogenetic trees based on mitochondrial small rRNA. Nucleic Acids Symp. Ser., 35: 275-276.


7.  Sekito, T., Okamoto, K., Kitano, H., and Yoshida, K. (1995). Clone bank of the mitochondrial genome of yeast Hansenula wingei. Yeast, 11: 1317-1321.


6.   Sekito, T., Okamoto, K., Kitano, H., and Yoshida, K. (1995). The complete mitochondrial DNA sequence of Hansenula wingei reveals new characteristics of yeast mitochondria. Curr. Genet., 28: 39-53.


5.   Sekito, T., Okamoto, K., Kitano, H., and Yoshida, K. (1994). Yeast Hansenula wingei mitochondrial genome's complete DNA sequence demonstrated unique characteristics. Nucleic Acids Symp. Ser., 31: 233-234.


4.  Okamoto, K., Sekito, T., and Yoshida, K. (1994). The mitochondrial genome of yeast Hansenula wingei encodes NADH dehydrogenase subunit genes ND4L and ND5. Mol. Gen. Genet., 243: 473-476.


3.  Sekito, T., Okamoto, K., Suzuki, K., and Yoshida, K. (1993). Nucleotide sequences and secondary structures of four tRNA genes in mitochondrial DNA of Hansenula wingei yeast. Nucleic Acids Res., 21: 3589.


2.  Okamoto, K., Suzuki, K., and Yoshida, K. (1992). Nucleotide sequences of ten mitochondrial tRNA genes in yeast Hansenula wingei. Nucleic Acids Res., 20: 2373.


1.  Okamoto, K., Suzuki, K., and Yoshida, K. (1991). Physical mapping and RFLP analysis of mtDNAs from the ascosporogenous yeasts: Saccharomyces exiguus, S. kluyveri and Hansenula wingei. Jpn. J. Genet., 66: 709-718.



総説・著書


13.  Komatsu, M., Kuma, A., Okamoto, K. (2013). No ATG is an island-the connection of autophagy with diverse pathways and functions. EMBO Rep., 14, 219-221.


12.  岡本浩二 (2012).マイトファジーの分子機構.オートファジー DOJIN BIOSCIENCE SERIES 04, 化学同人, 133-149.


11.  Kondo-Okamoto, N., and Okamoto, K. (2012). Mitochondria and autophagy: critical interplay between the two homeostats. Biochim. Biophys. Acta, 1820, 595-600


10.  岡本浩二 (2012).ミトコンドリア品質管理研究の最前線.細胞 THE CELL, 44: 45-48.


9.    Okamoto, K. (2011). Mitochondria breathe for autophagy. EMBO J., 30, 2095-2096.


8.    Kanki, T., Klionsky, D.J., Okamoto, K. (2011). Mitochondria autophagy in yeast. Antioxid. Redox Signal., 14, 1989-2001.


7.   岡本徳子,岡本浩二,大隅良典(2010).酵母のマイトファジー〜観察からの始まり〜.顕微鏡, 45: 83-86


6.   岡本浩二*,岡本徳子 (2010).マイトファジー:ミトコンドリアを丸ごと分別・除去する仕組み.細胞工学・特集「その時ミトコンドリアは動いた」,29: 423-428. *Corresponding authors


5.  岡本浩二* (2010).選択的ミトコンドリア分解のしくみ―垣間見えてきたパーキンソン病との関連.医学の歩み・第1土曜特集「ここまでわかったミトコンドリア研究の新展開」,232: 665-670. *Corresponding authors


4.  Okamoto, K.*, Kondo-Okamoto, N., and Ohsumi, Y.* (2009). A landmark protein essential for mitophagy. Autophagy, 5: 1203-1205. *Corresponding authors.


3.  Okamoto, K.*, and Shaw, J.M.* (2005). Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Ann. Rev. Genet., 39: 503-536. *Corresponding authors.


2.  Okamoto, K., Perlman, P.S., and Butow, R.A. (2001). Targeting of green fluorescent protein to mitochondria. Methods Cell Biol., 65: 277-283.


1.   岡本浩二, 関藤孝之, 北野広道, 吉田和夫 (1994). 酵母ミトコンドリアゲノムの構造とその多様性.蛋白質・核酸・酵素, 39: 1638-1650.