Research

Research Theme

The Project Leader's Profile

Atsushi Kumanogoh

Professor, Department of Immunopathlogy, Osaka University

Project Leader
  • Atsushi Kumanogoh, Professor
Research Members
  • Toshihiko Toyofuku, Associate Professor
  • Noriko Takegahara, Assistant Professor
  • Hyota Takamatsu, Postdoctoral fellow
  • Tatsusada Okuno, Postdoctoral fellow

Summary

Semaphorins are originally identified as axonal guidance factors in the developing nervous system in 1990s. Cumulative evidence suggests that semaphorins also play important roles in the other systems, including organogenesis, vascularization, angiogenesis and the progression of cancers. In 2000, our research groups have identified a class IV semaphorin, CD100/Sema4D, as an immune-regulatory molecule expressed on immune cells. To date, it becomes clear that some other semaphorins (Sema3A, Sema4A, Sema4B, Sema4G, Sema4F, Sema6A, Sema6B, Sema6D, Sema7A) are also expressed in the immune system and play non-redundant roles in immune responses. These semaphorins are now called as 'immune semaphorins' (Fig.1). Immune semaphorins are involved in various phases of immune responses including activation phase, differentiation phase and effecter phase (Fig.2). We work on the molecular mechanisms underlying regulation of immune responses by immune semaphorins.

kumanogoh1.JPG kumanogoh2.jpg

Some of Recent Papers

  1. Suzuki K, Kumanogoh A, Kikutani H. Semaphorins and their receptors in immune cell interactions. Nat Immunol. 9:17-23, 2008.
  2. Kikutani H., Suzuki K., and Kumanogoh A. Immune semaphorins: Increasing members and their diverse roles. Adv Immunol. 93:121, 2007.
  3. Suzuki K.et al., Semaphorin 7A initiates T cell-mediated inflammatory responses through  α1 β1 integrin. Nature 446:680-684, 2007
  4. Takegahara N.et al., Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol. 8, 615-622, 2006.
  5. Toyofuku T.et al.,The FERM domain containing GEF protein FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci. 8, 1712-1719, 2005.
  6. Kumanogoh A.et al., Nonredundant roles of Sema4A in the immune system: Defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice. Immunity 22, 305-16, 2005.
  7. Toyofuku T.et al., Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling. Nat Cell Biol. 6, 1204-11, 2004.
  8. H. Kikutani and A. Kumanogoh. Semaphorins in T cell-antigen presenting cell interactions. Nat. Rev. Immunol. 3, 159-167, 2003.
  9. Kumanogoh A.et al., Class IV semaphorin Sema4A enhances T cell activation and interacts with Tim-2. Nature 419, 629-633, 2002.
  10. Kumanogoh A.et al., Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity 13, 621-631, 2000.