2017

Yano T, Kanoh H, Tamura A, Tsukita S. 2017.
Apical cytoskeletons and tight junctions as a unified system in epithelial cell sheets.
Ann N Y Acad Sci, in press.

Tanaka H, Tamura A, Suzuki K, Tsukita S. 2017.
Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism.
Ann N Y Acad Sci, in press.

Tokumasu R, Tamura A, Tsukita S.
Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin.
Tissue Barriers. 2017 Jun 19:e1336194. doi: 10.1080/21688370.2017.1336194. [Epub ahead of print]  [PUBMED]

Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR.
IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance.
Cell Host Microbe. 2017 Jun 14;21(6):671-681.e4. doi: 10.1016/j.chom.2017.05.009.  [PUBMED]

Dunst J, Azzouz N, Liu X, Tsukita S, Seeberger PH, Kamena F.
Interaction between Plasmodium Glycosylphosphatidylinositol and the Host Protein Moesin Has No Implication in Malaria Pathology.
Front Cell Infect Microbiol. 2017 May 16;7:183. doi: 10.3389/fcimb.2017.00183. eCollection 2017.  [PUBMED]

Tateishi K, Nishida T, Inoue K, Tsukita S. 2017.
Three-dimensional Organization of Layered Apical Cytoskeletal Networks Associated with Mouse Airway Tissue Development.
Sci Rep. 2017 Mar 8;7:43783. doi: 10.1038/srep43783.  [PUBMED]

2016

Herawati E, Taniguchi D, Kanoh H, Tateishi K, Ishihara S, Tsukita S. 2016.
Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton.
J Cell Biol. 2016 Aug 29;214(5):571-86. doi: 10.1083/jcb.201601023.  [PUBMED]

Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I, Tsukita S. 2016.
Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis.
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4061-8. doi: 10.1073/pnas.1525474113.  [PUBMED]

Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M,Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K. 2016.
Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.
Mucosal Immunol. 2016 Jul 6. doi: 10.1038/mi.2016.58. [Epub ahead of print]  [PUBMED]

Okano T, Takeuchi S, Soma Y, Suzuki K, Tsukita S, Ishizu A, Suzuki K, Kawakami T. 2016.
Presence of anti-phosphatidylserine-prothrombin complex antibodies and anti-moesin antibodies in patients with polyarteritis nodosa.
J Dermatol. 2016 Jun 27. doi: 10.1111/1346-8138.13491. [Epub ahead of print]  [PUBMED]

Tanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, Fujiyoshi Y, Mineta K, Takeuchi K, Tamura A, Tsukita S.
Claudin-21 has a paracellular channel role at tight junctions.
Mol Cell Biol. 2016 Jan 4. pii: MCB.00758-15. [Epub ahead of print]  [PUBMED]

Konishi S, Gotoh S, Tateishi K, Yamamoto Y, Korogi Y, Nagasaki T, Matsumoto H, Muro S, Hirai T, Ito I, Tsukita S, Mishima M.
Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells.
Stem Cell Reports. 2016 Jan 12;6(1):18-25. doi: 10.1016/j.stemcr.2015.11.010. Epub 2015 Dec 24.  [PUBMED]

2015

Kamitani, T., Sakaguchi, H., Tamura, A., Miyashita, T., Yamazaki, Y., Tokumasu, R., Inamoto, R., Matsubara, A., Mori, N., Hisa, Y., and Tsukita, S. 2015.
 Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells.
  Sci Rep. 5:18402. doi: 10.1038/srep18402.[PUBMED]

Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M.
 Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Nat Commun. 2015 Apr 20;6:6872. doi: 10.1038/ncomms7872. [PUBMED]

Oneyama C, Yoshikawa Y, Ninomiya Y, Iino T, Tsukita S, Okada M.
 Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression.
Oncogene. 2015 Apr 13. doi: 10.1038/onc.2015.110. [Epub ahead of print] [PUBMED]

Tanaka H, Takechi M, Kiyonari H, Shioi G, Tamura A, Tsukita S.
 Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice.
Gut. 2015 Feb 17. pii: gutjnl-2014-308419. doi: 10.1136/gutjnl-2014-308419. [Epub ahead of print] [PUBMED]

Saitoh Y, Suzuki H, Tani K, Nishikawa K, Irie K, Ogura Y, Tamura A, Tsukita S, Fujiyoshi Y.
 Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin.
Science. 2015 Feb 13;347(6223):775-8. doi: 10.1126/science.1261833. [PUBMED]

Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Zhou S, Wang G, Cao L, Qian F, Taylor S, Oh MJ, Levitan I, Ye RD, Carnegie GK, Zhao Y, Malik AB, Xu J.
 Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient.
J Exp Med. 2015 Feb 9;212(2):267-80. doi: 10.1084/jem.20140508. Epub 2015 Jan 19. [PUBMED]

Suzuki H, Tani K, Tamura A, Tsukita S, Fujiyoshi Y.
 Model for the architecture of claudin-based paracellular ion channels through tight junctions.
J Mol Biol. 2015 Jan 30;427(2):291-7. doi: 10.1016/j.jmb.2014.10.020. Epub 2014 Nov 4. [PUBMED]

Hatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan MJ, Ueno Y, Tsukita S, and Asano S. 2015.
 Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice.
  Hepatology 61:1660-1671. doi: 10.1002/hep.27565.[PUBMED]

2008-2014

Noda K, Nakajima S, Godo S, Saito H, Ikeda S, Shimizu T, Enkhjargal B, Fukumoto Y, Tsukita S, Yamada T, Katagiri H, Shimokawa H.
 Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.
PLoS One. 2014 Nov 3;9(11):e110446. doi: 10.1371/journal.pone.0110446. eCollection 2014. [PUBMED]

Hatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan MJ, Ueno Y, Tsukita S, Asano S.*
 Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium.
Hepatology. 2014 Oct 13. [Epub ahead of print] [PUBMED]

Tamura A, Tsukita S.*
 Paracellular barrier and channel functions of TJ claudins in organizing biological systems: Advances in the field of barriology revealed in knockout mice.
Semin Cell Dev Biol. 2014 Oct 11. [Epub ahead of print] [PUBMED]

Adachi M, Kawasaki A, Nojima H, Nishida E, Tsukita S.*
 Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.
Genes Cells. 2014 Sep 17. [Epub ahead of print] [PUBMED]

Matsumoto Y, Inden M, Tamura A, Hatano R, Tsukita S, Asano S.*
 Ezrin mediates neuritogenesis via down-regulation of RhoA activity in cultured cortical neurons.
PLoS One. 2014 Aug 21;9(8):e105435. [PUBMED]

Nishimura T, Higuchi K, Sai Y, Sugita Y, Yoshida Y, Tomi M, Wada M, Wakayama T, Tamura A, Tsukita S, Soga T, Nakashima E.*
 Fetal growth retardation and lack of hypotaurine in ezrin knockout mice.
PLoS One. 2014 Aug 21;9(8):e105423. [PUBMED]

Matsumoto, K., et al.,
 Claudin 2 Deficiency Reduces Bile Flow and Increases Susceptibility to Cholesterol Gallstone Disease in Mice.
Gastroetenrology. in press.

Suzuki,H.#, Nishizawa,T.#, Tani,K.#, Yamazaki,Y., Tamura,A., Ishitani,R., Dohmae,N., Tsukita,S., Nureki,O.*, and Fujiyoshi,Y.* 2014.
 Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions.
Science 344:304-307. # :equal contribution

Yano, T., Matsui, T., Tamura, A., Uji, M., and Tsukita, S.*
 The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.
J Cell Biol. 2013 Nov 25;203(4):605-14. doi: 10.1083/jcb.201304194.

Tateishi, K., Yamazaki, Y., Nishida, T., Watanabe, S., Kunimoto, K., Ishikawa, H., and Tsukita, S.*
 Two appendages homologous between basal bodies and centrioles are formed using distinct Odf2 domains.
 J Cell Biol. 2013 Nov 11;203(3):417-25. doi: 10.1083/jcb.201303071. Epub 2013 Nov 4.

Suzuki, K., Nagao, T., Itabashi, M., Hamano, Y., Sugamata, R., Yamazaki, Y., Yumura, W., Tsukita, S., Wang, PC., Nakayama, T., and Suzuki, K.*
 A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis.
 Nephrol Dial Transplant. 2013 Dec 5. [Epub ahead of print]

Suzuki, H., Ito, Y., Yamazaki, Y., Mineta, K., Uji, M., Abe, K., Tani, K., Fujiyoshi, Y.*, and Tsukita, S*
 The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat.
 Nature Communication 4:1766.2013.

Hayashi, H., Tamura, A., Krishnan, D., Tsukita, S., Suzuki, Y., Kocinsky, HS., Aronson, PS., Orlowski, J., Grinstein, S., and Alexander, RT*.
 Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3.
 PLoS One. 8: e55623. 2013

Wada, M., Tamura, A., Takahashi, N., and Tsukita, S.
 Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na(+) Flow and Nutrient
  Transport in Gut and Leads to Death from Malnutrition.
 Gastroenterology Epub ahead of print

Hirata, T.*, Nomachi, A., Tohya, K., Miyasaka, M,, Tsukita, S., Watanabe, T., and Narumiya, S.
 Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis.
 Int. Immunol. 2012 Aug 8. [Epub ahead of print]

Lei, Z., Maeda, T., Tamura, A., Nakamura, T., Yamazaki, Y., Shiratori, H., Yashiro, K., Tsukita, S.*, and Hamada, H.*
 EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.
 Dev. Biol. 2012 Jul 17. [Epub ahead of print]

Tamura, A., Yamazaki Y,, Hayashi, D., Suzuki, K., Sentani, K., Yasui, W., and Tsukita, S.*
 Claudin-based paracellular proton barrier in the stomach. 2012.
 Ann. N Y Acad. Sci. 2012 Jul;1258:108-14. doi: 10.1111/j.1749-6632.2012.06570.x.

Itoh,M.*, Tsukita,S., Yamazaki,Y., and Sugimoto,H. 2012.
 ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-MLC signaling.
  Proc. Natl. Acad. Sci. U.S.A. 19;109:9905-9910.

Kunimoto, K., Yamazaki, Y.#, Nishida, T.#, Shinohara, K.#, Ishikawa, H.#, Hasegawa, T., Okanoue, T., Hamada, H., Noda, T., Tamura, A., Tsukita, S and Tsukita, S.* 2012.
 Coordinated Ciliary Beating Requires Odf2-Mediated Polarization of Basal Bodies via Basal Feet
 Cell 148;189-200. #:equal contribution

Hayashi, D. #, Tamura, A. #, Tanaka, H., Yamazaki, Y., Watanabe, S., Suzuki, K., Suzuki, K., Sentani, K., Yasui, W., Rakugi, H., Isaka, Y., and Tsukita, S. * 2012.
 Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β,
 and atrophic gastritis in mice.
 Gastroenterology, 142, 292-304. #:equal contribution

Yamazaki,Y.#, Tokumasu,R#., Kimura, H., and Tsukita,S.* 2011.
 Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens.
 Mol. Biol. Cell 22:1495-1504

Mineta, K.*, Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., Tamura, A., Igarashi, M., Endo, T., Takeuchi, K.*, and Tsukita, S.* 2011.
 Predicted expansion of the claudin multigene family.
 FEBS letters 585:606-612

Ibi M, Zou P, Inoko A, Shiromizu T, Matsuyama M, Hayashi Y, Enomoto M, Mori D, Hirotsune S, Kiyono T, Tsukita S, Goto H, Inagaki M. * 2011.
 Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
 J Cell Sci.124:857-864.

Koda, R., Zhao, L., Yaoita, E., Yoshida, Y., Tsukita, Sa., Tamura, A., Nameta, M., Zhang, Z., Fujinaka, H., Magdeldin, S., Xu, S., Narita, I., and Yamamoto, T.* 2011.
 Novel expression of claudin-5 in glomerular podocytes.
 Cell and Tissue research 343:637-648

Yamazaki,Y., Tamura,A., and Tsukita,Sa.* 2010.
 Water-based biological homeostasis in multiple fluid-compartments in the higher organisms:
 regulation by the paracellular barrier-forming tight junction of epithelial cell sheets.
 Water: The Forgotten Biological Molecule (Fukuyama, H. and Bihan,D.L., editors, PanStanford Publishin)
 Chapter 13

Tamura,A., Hayashi,H., Imasato,.M., Yamazaki,Y., Hagiwara,A., Wada,M., Noda,T., Watanabe, M., Suzuki,Y. and Tsukita,Sa.* 2010.
 Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption
 in mouse small intestine
 Gastroenterology 140:913-923.

Kunimoto,K., Nojima,H., Yamazaki,Y., Okanoue,T., and Tsukita,Sa.* 2009.
 Involvement of IQGAP3, a regulator of Ras/ERK-related Cascade, in Hepatocyte Proliferation
 in Mouse Liver   Regeneration and Development.
 J.Cell Physiol. 220:621-631.

Strilic, B., Kucera, T., Eglinger,J., Hughes,MR.,McNagny,KM.,Tsukita,Sa., Dejana,E., Ferrara,N., and Lamment,E.* 2009.
 Vascular lumen formation in the developing aorta.
 Dev. Cell 17:505-515.

Tsukita,Sa.*, Katsuno,T., Yamazaki,Y., Umeda,K.,Tamura,A., and Tsukita,Sh. 2009 (review).
 Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with
 paracellular permselective barrier function
 Ann. N Y. Acad Sci. 1165:44-52.

Adachi,M. *, Hamazaki,Y., Kobayashi,Y., Itoh,M., Tsukita,Sa., Furuse,M., and Tsukita,Sh. 2009.
 Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing
 Tight Junction   Proteins.
 Mol.Cell Biol. 29:2372-2389.

Tsukita,Sa.*, Yamazaki,Y., Katsuno,T., and Tamura,A. 2008 (review).
 Tight junction-based epithelial microenvironment and cell proliferation.
 Oncogene 27:6930-6938.

Ikenouchi,J.*, Sasaki,H., Tsukita,Sa., Furuse,M., and Tsukita,Sh. 2008.
 Loss of Occludin Affects Tricellular Localization of Tricellulin.
 Mol. Biol. Cell 19:4687-4693

Yamazaki,Y., Umeda,K., Wada,M., Nada,S., Okada,M., Tsukita,Sh., and Tsukita,Sa.* 2008.
 ZO-1/2-dependent integration of myosin-2 to epithelial zonula adherens.
 Mol. Biol. Cell 19:3801-3811.

Nojima,H., Adachi,M., Matsui,T., Tsukita,Sh., and Tsukita,Sa.* 2008.
 IQGAP3 regulates cell proliferation through the Ras/ERK signaling cascade
 Nature Cell Biol. 10:971-978.

Yamazaki,Y., Okawa,K., Yano,T., Tsukita,Sh., and Tsukita,Sa.* 2008.
 Optimized proteomic analysis on gels of cell-cell Adhering junctional membrane proteins.
 Biochemistry. 13;47:5378-5386. [PUBMED]

Katsuno,T., Umeda,K.,Matsui,T.,Hata,M.,Tamura,A.,Fujimori,T.,Nabeshima,Y.,Itoh,M.,Noda,T.,Tsukita,Sh.and Tsukita,Sa.* 2008.
 Deficiency of ZO-1 causes embryonic lethal phenotype associated with defected yolk sac
 angiogenesis and   apoptosis of embryonic cells.
 Mol. Biol. Cell 19:2465-2475. [PUBMED]

Tamura,A., Kitano,Y., Hata,M., Katsuno,T., Moriwaki,K., Sasaki,H., Hayashi,H., Suzuki,Y., Noda,T., Furuse,M., Tsukita,Sh., and Tsukita,Sa.*  2008. 
 Megaintestine in claudin-15deficient mice.
 Gastroenterology 134:523-534.[PUBMED]

Kubo,A.*, Yuba-Kubo,A., Tsukita,Sa., Tsukita,Sh., and Amagai,M. 2008.
 Sentan: A Novel Specific Component of the Apical Structure of Vertebrate Motile Cilia.
 Mol. Biol. Cell. 19:5338-46

Minami,S. ,Ito,K., Honma,M., Ikebuchi,Y., Anzai,N., Kanai,Y., Nishida,T., Tsukita,Sa., Sekine,S., Horie,T., and Suzuki,H.* 2008
 Post-translational regulation of Abcc2 expression by SUMOylation system.
 Am. J. Physiol. Gastrointest. Liver Physiol. in press

Kamiya,A., Tan,PL., Kubo,K., Engelhard,C., Ishizuka,K., Kubo,A., Tsukita,Sa.,Pulver,AE., Nakajima,K., Cascella,NG., Katsanis,N., and Sawa,A.* 2008.
 Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate
 for psychiatric illnesses.
 Arch. Gen. Psychiatry 65:996-1006.

Hashimoto,S., Amaya,F., Matsuyama,H., Ueno,H., Kikuchi,S., Tanaka,M., Watanabe,Y., Ebina,M., Ishizaka,A., Tsukita,Sa., and Hashimoto,S.* 2008.
 Dysregulation of lung injury and repair in moesin-deficient mice treated with intratracheal bleomycin.
 Am. J. Physiol. Lung Cell Mol. Physiol. 295:L566-L574.

Okayama,T., Kikuchi,S.*, Ochiai,T., Ikoma,H., Kubota,T., Ichikawa,D., Fujiwara,H., Okamoto,K., Sakakura,C., Sonoyama,T., Kokuba,Y., Doi,Y., Tsukita,Sa., Bissell,DM., and Otsuji,E. 2008.
 Attenuated response to liver injury in moesin-deficient mice: Impaired stellate cell
 migration and decreased fibrosis.
 Biochim. Biophys. Acta.-Molecular Basis of Disease 1782:542-548.

1997-2007

Yamane,J., Kubo,A., Nakayama,K., Yuba-Kubo,A., Katsuno,T., Tsukita,Sh., and Tsukita.Sa. 2007.
 Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic.
 Exp. Cell Res. 313:3472-3485.

Ikenouchi,J.*, Umeda,K., Tsukita,Sa.*, Furuse,M., and Tsukita,Sh. 2007.
 Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization.
 J. Cell Biol.  176:779-786.[PUBMED]

Fukumoto,K., Kikuchi,S., Itoh,N., Tamura,A., Hata,M., Yamagishi,H., Tsukita,Sh., and Tsukita,Sa.* 2007.
 Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to
 different expression levels of Mrp3.
 Biochim. Biophys. Acta.-Molecular Basis of Disease 1772:298-306.

Umeda,K., Ikenouchi,J., Katahira-Tayama,S., Furuse,K., Sasaki,H., Nakayama,M., Matsui,T., Tsukita,Sa.*, Furuse,M., and Tsukita,Sh. 2006.
 ZO-1 and ZO-2 determine independently determine where claudins are polymerized in tight-junction
 strand formation.
 Cell 126:741-754. [PUBMED]

Loebrich,S., Baring,R., Katsuno,T., Tsukita,Sa.,and Kneussel,M.*  2006.
 Activated radixin is essential for GABAA receptorα5 subunit anchoring at the actin cytoskeleton.
 EMBO J.  25:987-999.[PUBMED]

Ikenochi J., Furuse M., Furuse K., Sasaki H.,Tsukita Sa., and Tsukita Sh.*  2005.
 Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells.
 J. Cell Biol. 171:939-945.[PUBMED]

Tamura A., Kikuchi S., Hata M., Katsuno T., Matsui T., Hayashi H., Suzuki Y., Noda T., Tsukita, Sh., and Tsukita, Sa.* 2005.
 Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi
 in gastric parietal cells.
 J. Cell Biol.  169:21-28.[PUBMED]

Ishikawa H., Kubo A., Tsukita Sh., and Tsukita Sa.* 2005.
 Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia.
 Nature Cell Biol.  7:517-524.[PUBMED]

Kitajiri,S., Fukumoto,K., Hata,M., Sasaki,H., Katsuno,T., Nakagawa,T., Ito,J., Tsukita, Sh., and Tsukita,Sa. 2004.
 Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia.
 J. Cell Biol. 166:559-570.

Hoeflich,K.P., Tsukita,Sa., Hicks,L., Kay,C.M., Tsukita,Sh., and Ikura,M. 2003.
 Insights into a single rod-like helix in activated radixin required for membrane-cytoskeletal cross-linking.
 Biochemistry 42:11634-11641.

Hamada,K., Shimizu,T., Yonemura,S., Tsukita,Sh., Tsukita,Sa., and Hakoshima,T. 2003.
 Structural basis of adhesion-molecule recognition by ERM proteins by the crystal structure of the  radixin-ICAM-2 complex.
 EMBO J. 22:502-514.

Kikuchi,S., Hata,M., Fukumoto,K., Yamane,Y., Matsui,T., Tamura,A., Yonemura,S., Yamagishi,H., Keppler,D., Tsukita,Sh., and Tsukita,Sa.* 2002.
 Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes.
 Nature Genetics 31:320-325.

Yonemura,S., Matsui,T., Tsukita,Sh., and Tsukita,Sa. 2002.
 Rho-dependent and -independent activation mechanisms of Ezrin/Radixin/Moesin proteins :
 An essential role of polyphosphoinositides in vivo.
 J. Cell Sci. 115:2569-2580.

Shimizu,T., Seto,A., Maita,N., Hamada,K., Tsukita,Sh., Tsukita,Sa., and Hakoshima,T. 2002.
 Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.
 J. Biol. Chem. 277:10332-10336.

Ishikawa,H., Tamura,A., Matsui,T., Sasaki,H., Hakoshima,T., Tsukita,Sh., and Tsukita,Sa. 2001.
 Structural conversion between open and closed forms of radixin: Low-angle shadowing electron microscopy.
 J. Mol. Biol. 310:973-978.

Hamada,K., Shimizu,T., Matsui,T., Tuskita,Sh., Tsukita,Sa., and Hakoshima,T. 2001.
 Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail
 of the adhesion protein ICAM-2.
 Acta Crystallogr. D. Biol. Crystallogr. 57:891-892.

Hamada,K., Seto,A., Shimizu,T., Matsui,T.,Takai,Y., Tsukita,Sh., Tsukita,Sa., and Hakoshima,T. 2001.
 Crystallization and preliminary crystallographic studies of RhoGDI in complex with the radixin FERM domain.
 Acta Crystallogr. D. Biol. Crystallogr. 57:889-890.

Nakagawa,Y., Yamane,Y., Okanoue,T., Tsukita,Sh. , and Tsukita,Sa. 2001.
 Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated
 with mother centrioles: Its identification from isolated centrosomes.
 Mol. Biol. Cell 12:1687-1697.

Hamada,K., Shimizu,T., Matsui,T., Tsukita,Sh., Tsukita,Sa., and Hakoshima,T. 2000.
 Structural basis of the membrane-targeting and unmasking mechanism of radixin FERM domain.
 EMBO J. 19:4449-4462.

Hamada,K., Matsui,T., Tsukita,Sh., Tsukita,Sa., and Hakoshima,T. 2000.
 Crystallographic characterization of the membrane-binding domain of radixin.
 Acta Crystallogr. D. Biol. Crystallogr. 56:922-923.

Xiao,S., Komiya,K., Tochikura,T.S., Sagara,J., Tsukita,Sa., and Kawai A. 2000.
 The rabies virion-associated 100-kDa polypeptide (VAP100) is a host-derived minor component
 of the viral envelope.
 Microbiol. Immunol. 44:657-68.

Tsukita,Sa. and Yonemura,S. 1999.
 Cortical actin organization: Lessons from ERM (ezrin/radixin/moesin) proteins.
 J. Biol. Chem. 274:34507-34510.

Matsui,T., Yonemura,S., Tsukita,Sh., and Tsukita,Sa. 1999.
 Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol-4-phosphate 5-kinase
 and not ROCK kinases.
 Curr. Biol. 9:1259-1262.

Maeda,M., Matsui,T., Imamura,M., Tsukita,Sh., and Tsukita,Sa. 1999.
 Expression level, subcellular distribution and Rho-GDI binding affinity of merlin in comparison
 with ezrin/radixin/moesin proteins.
 Oncogene 18:4788-4797.

Hayashi,K., Yonemura,S., Matsui,T., Tsukita,Sa., and Tsukita,Sh. 1999.
 Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal
 threonine phosphorylated in cultured cells and tissues: Application of a novel fixation protocol
 using trichloro-acetic (TCA) as a fixative.
 J.Cell Sci. 112:1149-1158.

Yonemura,S., Tsukita,Sa., and Tsukita,Sh. 1999.
 Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization
 of microvilli in collaboration with activated ERM proteins
 J.Cell Biol. 145:1497-1506.

Doi,Y., Itoh,M., Yonemura,S., Ishihara,S., Takano,H., Noda,T., Tsukita,Sh., and Tsukita,Sa. 1999.
 Moesin gene knockout: Normal development of mice and unimpaired cell adhesion /cell
 motiltiy/actin-based cytoskeleton without compensatory up-regulation of ezrin and radixin.
 J. Biol. Chem. 274:2315-2321.



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