• 主な発表論文| 1 | 2 | 3 | 4 | 5 |                    全発表論文はこちら
  •                    *:corresponding author

Yano T, Kanoh H, Tamura A, Tsukita S. 2017.
 Apical cytoskeletons and tight junctions as a unified system in epithelial cell sheets.
 Ann N Y Acad Sci, in press.

Tanaka H, Tamura A, Suzuki K, Tsukita S. 2017.
 Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism.
 Ann N Y Acad Sci, in press.

Tokumasu R, Tamura A, Tsukita S.
 Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin.
 Tissue Barriers. 2017 Jun 19:e1336194. doi: 10.1080/21688370.2017.1336194. [Epub ahead of print]  [PUBMED]

Tateishi K, Nishida T, Inoue K, Tsukita S. 2017.
 Three-dimensional Organization of Layered Apical Cytoskeletal Networks Associated with Mouse Airway Tissue Development.
 Sci Rep. 2017 Mar 8;7:43783. doi: 10.1038/srep43783.[PUBMED]

Herawati E, Taniguchi D, Kanoh H, Tateishi K, Ishihara S, Tsukita S. 2016.
 Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton.
 J Cell Biol. 2016 Aug 29;214(5):571-86. doi: 10.1083/jcb.201601023[PUBMED]

Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I, Tsukita S. 2016.
 Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis.
  Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4061-8. doi: 10.1073/pnas.1525474113.[PUBMED]

Tanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, Fujiyoshi Y, Mineta K, Takeuchi K, Tamura A, Tsukita S. 2016.
 Claudin-21 has a paracellular channel role at tight junctions.
  Mol Cell Biol. 2016 Jan 4. pii: MCB.00758-15. [Epub ahead of print][PUBMED]

Konishi S, Gotoh S, Tateishi K, Yamamoto Y, Korogi Y, Nagasaki T, Matsumoto H, Muro S, Hirai T, Ito I, Tsukita S, Mishima M. 2015.
 Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells.
  Stem Cell Reports. 2016 Jan 12;6(1):18-25. doi: 10.1016/j.stemcr.2015.11.010. Epub 2015 Dec 24.[PUBMED]

Kamitani, T., Sakaguchi, H., Tamura, A., Miyashita, T., Yamazaki, Y., Tokumasu, R., Inamoto, R., Matsubara, A., Mori, N., Hisa, Y., and Tsukita, S. 2015.
 Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells.
  Sci Rep. 5:18402. doi: 10.1038/srep18402.[PUBMED]

Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M.
 Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
  Nat Commun. 2015 Apr 20;6:6872. doi: 10.1038/ncomms7872.[PUBMED]

Tanaka H, Takechi M, Kiyonari H, Shioi G, Tamura A, Tsukita S.
 Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice.
  Gut. 2015 Feb 17. pii: gutjnl-2014-308419. doi: 10.1136/gutjnl-2014-308419. [Epub ahead of print][PUBMED]

Saitoh Y, Suzuki H, Tani K, Nishikawa K, Irie K, Ogura Y, Tamura A, Tsukita S, Fujiyoshi Y.
 Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin.
  Science. 2015 Feb 13;347(6223):775-8. doi: 10.1126/science.1261833.[PUBMED]

Suzuki H, Tani K, Tamura A, Tsukita S, Fujiyoshi Y.
 Model for the architecture of claudin-based paracellular ion channels through tight junctions.
  J Mol Biol. 2015 Jan 30;427(2):291-7. doi: 10.1016/j.jmb.2014.10.020. Epub 2014 Nov 4.[PUBMED]

Yano, T., Matsui, T., Tamura, A., Uji, M., and Tsukita, S.*2013.
 The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.
  J Cell Biol. 2013 Nov 25;203(4):605-14. doi: 10.1083/jcb.201304194.[PUBMED]

Tateishi, K., Yamazaki, Y., Nishida, T., Watanabe, S., Kunimoto, K., Ishikawa, H., and Tsukita, S.*2013.
 Two appendages homologous between basal bodies and centrioles are formed using distinct Odf2 domains.
  J Cell Biol. 2013 Nov 11;203(3):417-25. doi: 10.1083/jcb.201303071. Epub 2013 Nov 4.[PUBMED]

Suzuki, K., Nagao, T., Itabashi, M., Hamano, Y., Sugamata, R., Yamazaki, Y., Yumura, W., Tsukita, S., Wang, PC., Nakayama, T., and Suzuki, K.*2013.
 A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis.
  Nephrol Dial Transplant. 2013 Dec 5. [Epub ahead of print][PUBMED]

Suzuki, H., Ito, Y., Yamazaki, Y., Mineta, K., Uji, M., Abe, K., Tani, K., Fujiyoshi, Y.*, and Tsukita, S. * 2013.
 The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat.
  Nature Communication 2013 Apr 23;4:1766[PUBMED]

Wada, M., Tamura, A., Takahashi, N., and Tsukita, S.
 Loss of Claudins 2 and 15 From Mice Causes Defects
 in Paracellular Na(+) Flow and Nutrient Transport in
 Gut and Leads to Death from Malnutrition.
  Gastroenterology Epub ahead of print[PUBMED]

Kunimoto, K., Yamazaki, Y.#, Nishida, T.#, Shinohara, K.#, Ishikawa, H.#, Hasegawa, T., Okanoue, T., Hamada, H., Noda, T., Tamura, A., Tsukita, S and Tsukita, S. * 2012.
 Coordinated Ciliary Beating Requires Odf2-Mediated
 Polarization of Basal Bodies via Basal Feet
  Cell 148;189-200. #:equal contribution[PUBMED]

Itoh,M.*, Tsukita,S., Yamazaki,Y., and Sugimoto,H. 2012.
 ARHGEF11 regulates the integrity of epithelial junctions
  by connecting ZO-1 and RhoA-MLC signaling.
  Proc. Natl. Acad. Sci. U.S.A. 19;109:9905-9910.[PUBMED]

Hayashi, D.#, Tamura, A.#, Tanaka, H., Yamazaki, Y., Watanabe, S., Suzuki, K., Suzuki, K., Sentani, K., Yasui, W., Rakugi, H., Isaka, Y., and Tsukita, S. * 2012. 
 Deficiency of claudin-18 causes paracellular H+ leakage,
 up-regulation of interleukin-1β, and atrophic gastritis in mice.
 Gastroenterology, 142:292-304. #:equal contribution [PUBMED]

Yano, T. #, Yamazaki, Y. #, Adachi, M., Okawa, K., Fort, P., Uji, M., Tsukita, S, and Tsukita, S. *2011.
 Tara up-regulates E-cadherin transcription by binding to
 the Trio RhoGEF and inhibiting Rac-signaling .
 J. Cell Biol. 193:319-332. #:equal contribution[PUBMED]

Yamazaki,Y.#, Tokumasu,R.#, Kimura, H., and Tsukita,S.* 2011.
 Role of claudin species-specific dynamics in reconstitution
 and remodeling of the zonula occludens.
 Mol. Biol. Cell 22:1495-1504. #:equal contribution[PUBMED]

Mineta, K.*, Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., Tamura, A., Igarashi, M., Endo, T., Takeuchi, K.*, and Tsukita, Sa.* 2011.
 Predicted expansion of the claudin multigene family.
 FEBS letters 585:606-612. [PUBMED]

Tamura,A., Hayashi,H., Imasato,.M., Yamazaki,Y., Hagiwara,A., Wada,M., Noda,T., Watanabe, M., Suzuki,Y. and Tsukita,Sa.* 2010.
 Loss of claudin-15, but not claudin-2, causes Na+ deficiency
 and glucose malabsorption in mouse small intestine
 Gastroenterology 140:913-923.[PUBMED]

Kunimoto,K., Nojima,H., Yamazaki,Y., Okanoue,T., and Tsukita,Sa.* 2009.
 Involvement of IQGAP3, a regulator of Ras/ERK-related
 Cascade, in Hepatocyte Proliferation in Mouse Liver
 Regeneration and Development.
 J.Cell Physiol. 220:621-631. [PUBMED]

Strilic, B., Kucera, T., Eglinger, J., Hughes, MR., McNagny, KM., Tsukita, Sa., Dejana, E., Ferrara, N., and Lamment, E.* 2009.
 The Molecular Basis of Vascular lumen formation
 in the developing aorta.
 Dev. Cell 17(4):505-515:.[PUBMED]

Tsukita,Sa.*, Katsuno,T., Yamazaki,Y., Umeda,K.,Tamura,A., and Tsukita,Sh. 2009 (review).
 Roles of ZO-1 and ZO-2 in establishment of the belt-like
 adherens and tight junctions with paracellular permselective
 barrier function.
 Ann. N Y. Acad Sci. 1165:44-52.[PUBMED]

Adachi,M. *, Hamazaki,Y., Kobayashi,Y., Itoh,M., Tsukita,Sa., Furuse,M., and Tsukita,Sh. 2009.
 Similar and Distinct Properties of MUPP1 and Patj, Two
 Homologous PDZ Domain-Containing Tight Junction Proteins.
 Mol.Cell Biol. 29:2372-2389. [PUBMED]

Tsukita,Sa.*, Yamazaki,Y., Katsuno,T., and Tamura,A. 2008 (review).
 Tight junction-based epithelial microenvironment and cell
 proliferation.
 Oncogene 27:6930-6938.[PUBMED]

Nojima,H., Adachi,M., Matsui,T., Tsukita,Sh., and Tsukita,Sa. * 2008.
 IQGAP3 regulates cell proliferation through the Ras/ERK
 signaling cascade
 Nature Cell Biol. 10:971-978.[PUBMED]

Tamura,A., Kitano,Y., Hata,M., Katsuno,T., Moriwaki,K., Sasaki,H., Hayashi,H., Suzuki,Y., Noda,T., Furuse,M., Tsukita,Sh., and Tsukita,Sa.*  2008. 
 Megaintestine in claudin-15deficient mice.
 Gastroenterology.  134:523-534.[PUBMED]

Yamazaki,Y., Umeda,K., Wada,M., Nada,S., Okada,M., Tsukita,Sh., and Tsukita,Sa.* 2008.
 ZO-1/2-dependent integration of myosin-2 to epithelial
 zonula adherens.
 Mol. Biol. Cell 19:3801-3811. [PUBMED]

Ikenouchi,J.*, Umeda,K., Tsukita,Sa.*, Furuse,M., and Tsukita,Sh. 2007.
 Requirement of ZO-1 for the formation of belt-like adherens
 junctions during epithelial cell polarization.
 J. Cell Biol.  176:779-786.[PUBMED]

Umeda,K., Ikenouchi,J., Katahira-Tayama,S., Furuse,K., Sasaki,H., Nakayama,M., Matsui,T., Tsukita,Sa.*, Furuse,M., and Tsukita,Sh. 2006.
 ZO-1 and ZO-2 determine independently determine where
 claudins are polymerized in tight-junction strand formation.
 Cell  126:741-754. [PUBMED]

Loebrich,S., Baring,R., Katsuno,T., Tsukita,Sa.,and Kneussel,M.*  2006.
 Activated radixin is essential for GABAA receptorα5 subunit
 anchoring at the actin cytoskeleton.
 EMBO J.  25:987-999.[PUBMED]

Ikenochi J., Furuse M., Furuse K., Sasaki H.,Tsukita Sa., and Tsukita Sh.*  2005.
 Tricellulin constitutes a novel barrier at tricellular contacts
 of epithelial cells.
 J. Cell Biol. 171:939-945.[PUBMED]

Tamura,A., Kikuchi,S., Hata,M., Katsuno,T., Matsui,T., Hayashi,H., Suzuki,Y., Noda,T., Tsukita,Sh., and Tsukita,Sa.* 2005.
 Achlorhydria by ezrin knockdown: defects in the
 formation/expansion of apical canaliculi in gastric
 parietal cells.
 J. Cell Biol.  169:21-8.[PUBMED]

Ishikawa,H., Kubo,A., Tsukita,Sh., and Tsukita,Sa.* 2005.
 Odf2-deficient mother centrioles lack distal/subdistal
 appendages and the ability to generate primary cilia.
 Nature Cell Biol.  7:517-524.[PUBMED]

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