Graduate School of Frontier Biosci., Osaka Univ.

Publications

2023

2022

2019

  • Hashimoto M, Sasaki H (2019)
    Epiblast formation by TEAD-YAP-dependent expression of pluripotency factors and competitive elimination of unspecified cells.
    Dev Cell 50(2):139–154.e5.
    doi: 10.1016/j.devcel.2019.05.024
    PMID: 31204175
    Recommended in F1000Prime. Also selected as a Featured Article, and was commented in Previews

2018

  • Kamura K, Shin J, Kiyonari H, Abe T, Shioi G, Fukuhara A, Sasaki H. (2018)
    Obesity in Yap transgenic mice is associated with TAZ downregulation.
    Biochem Biophys Res Commun. 505:951–957
    doi: 10.1016/j.bbrc.2018.10.037
    PMID: 30309656
  • Saito K, Kawasoe R, Sasaki H, Kawaguchi A, *Miyata T. (2018)
    Neural Progenitor Cells Undergoing Yap/Tead-Mediated Enhanced Self-Renewal Form Heterotopias More Easily in the Diencephalon than in the Telencephalon.
    Neurochem. Res. 43:171–180
    doi: 10.1007/s11064-017-2390-x
    PMID: 28879493

2017

  • Watanabe Y, Miyasaka KY, Kubo A, Kida YS, Nakagawa O, Hirate Y, Sasaki H, *Ogura T. (2017)
    Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm.
    Sci. Rep. Apr 12;7:46135
    doi: 10.1038/srep46135
    PMID: 28401892
  • Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP, Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP, Shimono A, Shiratori H, *Hamada H. (2017)
    A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
    Dev. Cell. Mar 13;40(5):439–452.e4
    doi: 10.1016/j.devcel.2017.02.010
    PMID: 28292423

2016

  • Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis AK, Sawa Y, Sasaki H, Ozono K, Suzuki K, *Yashiro K (2016)
    GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.
    Cell Rep. 16, 1026–38
    doi: 10.1016/j.celrep.2016.06.050

2015

  • Hirate Y, Hirahara S, Inoue K-i, Kiyonari H, Niwa H, *Sasaki H (2015)
    Par-aPKC-Dependent and -Independent Mechanisms Cooperatively Control Cell Polarity, Hippo Signaling, and Cell Positioning in 16-Cell Stage Mouse Embryos.
    Dev. Growth Differ. 57, 544–556
    doi: 10.1111/dgd.12235
  • Mamada H, Sato T, Ota M, *Sasaki H. (2015)
    Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc.
    J. Cell Sci. 128, 790–803

2014

  • Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, *Sasaki H (2014)
    Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos
    Mech. Dev. 132, 44–58
    doi: 10.1016/j.mod.2014.01.004
  • Wicklow E, Blij S, Frum R, Hirate Y, Lang RA, Sasaki H, *Ralston A. (2014)
    HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst
    PLoS Genet. 10, e1004618
    doi: 10.1371/journal.pgen.1004618
  • Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J, *Manzanares M. (2014)
    Notch and hippo converge on cdx2 to specify the trophectoderm lineage in the mouse blastocyst.Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos
    Dev. Cell. 30, 410–422
    doi: 10.1016/j.devcel.2014.06.019
  • Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, *Nishinakamura R. (2014)
    Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.
    Cell Stem Cell 14, 53–67
    doi: 10.1016/j.stem.2013.11.010

2013

  • Hirate Y, Hirahara S, Inoue K-i, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, *Sasaki H (2013)
    Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.
    Curr. Biol. 23, 1181–1194
    doi: 10.1016/j.cub.2013.05.014
    Selected for F1000Prime. Also selected as a Featured Article, and was commented in Dispatches.
  • Imuta Y, Kiyonari H, Jang CW, Behringer RR, *Sasaki H (2013)
    Generation of knock-in mice that express nuclear EGFP and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci.
    Genesis. 51, 210–218
    doi: 10.1002/dvg.22376

2012

  • Hirate Y, Cockburn K, Rossant J,*Sasaki H (2012)
    Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation embryos.
    Proc. Natl. Acad. Sci. USA 109:E3389–90
    doi: 10.1073/pnas.1211810109
  • Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, *Hamada H. (2012)
    Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.
    Science 338, 226–231.
  • Tao H, Inoue KI, Kiyonari H, Bassuk AG, Axelros JD, Sasaki H, Aizawa S, *Ueno N (2012)
    Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.
    Dev. Biol. 364, 138–148

2011

  • Wada K-I, Itoga K, Okano T, Yonemura S, *Sasaki H (2011)
    Hippo pathway regulation by cell morphology and stress fibers.
    Development 138, 3907–3914
  • Sansores-Garcia L, Bossuyt W, Wada KI, Yonemura S, Tao C, Sasaki H, *Halder G. (2011)
    Modulating F-actin organization induces organ growth by affecting the Hippo pathway.
    EMBO J. 30, 2325–2335
  • Mavromatakis YE, Lin W, Metzakopian E, Ferri AL, Yan CH, Sasaki H, Whisett J, *Ang SL (2011).
    Foxa1 and Foxa2 positively and negatively regulate Shh signaling to specify ventral midbrain progenitor identity.
    Mech. Dev. 128, 90–103

2010

  • Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, *Rossant J (2010)
    Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
    Development 137, 395–403

2009

  • Nishioka N, Inoue K-I, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, *Sasaki H. (2009)
    The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.
    Dev. Cell 16, 398–410
    Selected by Faculty of 1000 (must read)
  • Imuta Y, Nishioka N, Kiyonari H, *Sasaki H. (2009)
    Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124)
    Dev. Dyn. 238, 210–222
  • Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang C-W, Oginuma M, Saga Y, Behringer RR, Kondoh H, *Sasaki H. (2009)
    Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord.
    Mech. Dev. 126, 791–803
  • Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, *Ang S-L. (2009)
    Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.
    Dev. Biol. 333, 386–396

2008

  • Ota M, *Sasaki H. (2008)
    Mammalian Tead proteins regulate cell proliferation and contact inhibition as a transcriptional mediator of Hippo signaling.
    Development 135, 4059–4069
  • Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, *Sasaki H. (2008)
    Cthrc1 selectively activates planar cell polarity pathway of Wnt signaling by stabilizing Wnt-receptor complex.
    Dev. Cell 15, 23–36
    Selected by Faculty of 1000 (must read)
  • Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, *Sasaki H. (2008)
    Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.
    Mol. Cell. Biol. 28, 3177–3189
  • Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, *Sasaki H. (2008)
    Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.
    Mech. Dev. 125, 270–283
    Mech. Dev. Top Cited Article 2008-2010

2007

  • Ferri AL, Lin W, Mavromatikis YE, Wang JC, Sasaki H, Whitsett JA, *Ang SL. (2007)
    Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.
    Development 134, 2761–2769
  • Haraguchi R, Motoyama J, Sasaki H, Satoh Y, Miyagawa S, Nakagawa N, Moon A, *Yamada G (2007)
    Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.
    Development 134, 525–533

2006

  • Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, *Okano M (2006)
    DNA methylation regulates long-range gene silencing of an X-linked homedobox gene cluster in a lineage-specific manner.
    Genes Dev. 20, 3382–3394

2005

  • Sawada A, Nishizaki Y, Sato H, Yada Y, Nakayama R, Yamamoto S, Nishioka N, Kondoh H, *Sasaki H. (2005)
    Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor.
    Development 132, 4719–4729
  • Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, *Sasaki H (2005)
    Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex
    Development 132, 2535–2546
  • Takada T, Iida K, Sasaki H, Taira T, *Kimura H (2005)
    Expression of ADP-ribosylation factor (ARF)-like protein 6 (ARL6) during mouse embryonic development.
    Int. J. Dev. Biol. 49, 891–894

2020

2017

  • Sasaki H. (2017)
    Roles and regulations of Hippo signaling during preimplantation mouse development.
    Dev. Growth Differ. 59, 12–20
    doi: 10.1111/dgd.12335
    PMID: 28035666

2016

  • 竹之下憂祐、加村啓一郎、*佐々木洋 (2016)
    マウス胚線維芽細胞 NIH3T3 を用いた細胞競合モデル系の確立
    生体の科学 67, 111–115

2015

  • Sasaki H. (2015)
    Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos.
    Semi. Cell Dev. Biol. pii: S1084-9521(15)00100-7
    doi: 10.1016/j.semcdb.2015.05.003

  • 佐藤卓史、*佐々木洋 (2015)
    Hippo シグナルによる細胞競合の制御
    実験医学 33, 2920–2925

2014

  • Hirate Y, *Sasaki H (2014)
    The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development.
    Tissue Barriers 2, e28127
  • Kondoh H, Kuroiwa A (eds.), New Principles in Developmental Processes, Springer (2014)
    Sasaki H “Position-dependent Hippo signaling controls cell fates in preimplantation mouse embryos” pp 249–264

2013

  • Oren M., Aylon Y. (eds.), The Hippo Signalin Papthway and Cancer, Springer (2013)
    Sasaki H. “Role of Hippo signaling in early mouse development” pp 41–54

2011

  • 佐々木洋、平手良和 (2011)
    マウス初期胚発生における Hippo シグナル経路の役割
    細胞工学 30, 935–940
  • 佐々木洋、儘田博志 (2011)
    Hippo シグナル経路による細胞間のコミュニケーション
    実験医学 29, 1387–1392
  • 小幡祐一、城石俊彦、芹川忠夫、田中啓二、米川博通 編
    生物機能モデルと新しいリソース・リサーチツール、エル・アイ・シー (2011)
    佐々木洋「初期発生―体軸形成」pp 55–68

2010

  • Sasaki, H. (2010)
    Mechanisms of trophectoderm fate specification in preimplantation mouse development.
    Dev. Growth Differ. 52, 263–273

2008

  • 山元進司、佐々木洋 (2008)
    Cthrc1 は Wnt と受容体を安定化して平面内細胞極性シグナル経路を選択的に活性化する。
    細胞工学 27, 1294–1295