業績 ~ACHIEVEMENT~



原著論文



2019年

Hiromi Miyazaki, Yasuyuki Tsunoi, Takami Akagi, Shunichi Sato, Mitsuru Akashi, Daizoh Saitoh, A novel strategy to engineer prevascularized 3-dimensional skin substitutes to achieve efficient, functional engraftment, Sci. Rep., 9, 7797 (2019).

Hiroe Oikiri, Yoshiya Asano, Michiya Matsusaki, Mitsuru Akashi, Hiroshi Shimoda, Yoshihito Yokoyama, Inhibitory effect of carbonyl reductase 1 against peritoneal progression of ovarian cancer: evaluation by ex vivo 3D‑human peritoneal model, Mol. Biol. Rep. (2019). doi: 10.1007/s11033-019-04788-6.

Kyoko Nishiyama, Takami Akagi, Soichi Iwai, Mitsuru Akashi, Construction of Vascularized Oral Mucosa Equivalents Using a Layer-by-layer Cell Coating Technology, Tissue Eng. Part C Methods, 25, 262-275 (2019)

Akihiro Nishiguchi, Catherine Gilmore, Aman Sood, Michiya Matsusaki, Gavin Collett, Dionne Tannetta, Ian L. Sargent, Jennifer McGarvey, Nagaraj D. Halemani, Jon Hanley, Fiona Day, Simon Grant, Catherine Murdoch-Davis, Helena Kemp, Paul Verkade, John D. Aplin, Mitsuru Akashi, C Patrick Case, In Vitro Placenta Barrier Model Using Primary Human Trophoblasts, Underlying Connective Tissue and Vascular Endothelium, Biomaterials, 192, 140-148 (2019).

Soichi Iwai, Satoko Kishimoto, Yuto Amano, Akihiro Nishiguchi, Michiya Matsusaki, Akinori Takeshita, Mitsuru Akashi, Three‐dimensional cultured tissue constructs that imitate human living tissue organization for analysis of tumor cell invasion, J. Biomed. Mate.r Res. Part A, 107, 292–300 (2019).


2018年
Gianpiero Lazzari, Valerie Nicolas, Michiya Matsusaki, Mitsuru Akashi, Patrick Couvreur, Simona Mura, Multicellular Spheroid Based on a Triple Co-culture: A Novel 3D Model to Mimic Pancreatic Tumor Complexity, Acta Biomaterialia, 78, 296-307 (2018).

Akihiro Nishiguchi, Michiya Matsusaki, Mitsunobu R. Kano, Hiroshi Nishihara, Daisuke Okano, Yoshiya Asano, Hiroshi Shimoda, Satoko Kishimoto, Soichi Iwai, Mitsuru Akashi, In vitro 3D blood/lymph-vascularized human stromal tissues for preclinical assays of cancer metastasis, Biomaterials, 179, 144-155 (2018).

Chizuru Asahara, Takuya Iwamoto, Mitsuru Akashi, Hajime Shigemitsu, Toshiyuki Kida, Effective Guest Inclusion by a 6‐O‐Modified β‐Cyclodextrin Dimer in Organic Solvents, ChemPlusChem, 83, 868-873 (2018).

Mayumi Ikeda, Takami Akagi, Masao Nagao, Mitsuru Akashi, Development of analytical methods for evaluating the quality of dissociated and associated amphiphilic poly(γ-glutamic acid) nanoparticles, Anal. Bioanal.Chem. 410, 4445–4457 (2018).

Taisuke Masuda, Mitsuhiro Ukiki, Yuka Yamagishi, Michiya Matsusaki, Mitsuru Akashi, Utako Yokoyama, Fumihito Arai, Fabrication of engineered tubular tissue for small blood vessels via three-dimensional cellular assembly and organization ex vivo, J. Biotechnol., 276–277, 46-53 (20 18).

Daheui Choi, Misaki Komeda, Jiwoong Heo, Jinkee Hong, Michiya Matsusaki, Mitsuru Akashi, Vascular Endothelial Growth Factor Incorporated Multilayer Film Induces Preangiogenesis in Endothelial Cells, ACS Biomater. Sci. Eng., 4, 1833-1842 (2018).

Nalinthip Chanthaset, Hiroharu Ajiro, Mitsuru Akashi, Chantiga Choochottiros, A novel comb-shaped polymethacrylate-based copolymers with immobilized 2,4-dihydroxybenzaldehyde for antifungal activity, Polym. Bull., 75, 1349-1363 (2018).

Yasunari Fukuda, Takami Akagi, Tadafumi Asaoka, Hidetoshi Eguchi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Masaki Mori, Yuichiro Doki, Mitsuru Akashi, Layer-by-layer cell coating technique using extracellular matrix facilitates rapid fabrication and function of pancreatic β-cell spheroids, Biomaterials, 160, 82-91 (2018).

Yoshiya Asano, Hiroshi Shimoda, Michiya Matsusaki, Mitsuru Akashi, Transplantation of artificial human lymphatic vascular tissues fabricated using a cell-accumulation technique and their engraftment in mouse tissue with vascular remodeling, J. Tissue Eng. Regen. Med., 12, e1501-e1510 (2018).

Mayumi Ikeda, Takami Akagi, Tatsuya Yasuoka, Masao Nagao, Mitsuru Akashi, Characterization and Analytical Development for Amphiphilic Poly(γ-glutamic acid) as raw material of Nanoparticle Adjuvants. J. Pharm. Biomed. Anal., 150, 460-468 (2018).

Sarah Bertlein, Daichi Hikimoto, Gernot Hochleitner, Julia Huemmer, Tomasz Juengst, Michiya Matsusaki, Mitsuru Akashi, Juergen Groll, Development of Endothelial Cell Networks in 3D-Tissues by Combination of Melt Electrospinning Writing with Cell-accumulation Technology, Small, 14, 1701521 (2018).

Yu Bin Lee, Joong-yup Lee, Hayeon Byun, Taufiq Ahmad, Mitsuru Akashi, Michiya Matsusaki, Heungsoo Shin, One-step delivery of a functional multi-layered cell sheet using a thermally expandable hydrogel with controlled presentation of cell adhesive proteins, Biofabrication, 10, 025001 (2018).

Maki Takeda, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Emiko Ito, Akima Harada, Ryohei Matsuura, Hiroko Iseoka, Nagako Sougawa, Noriko Mochizuki-Oda, Michiya Matsusaki, Mitsuru Akashi, Yoshiki Sawa, Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells, Tissue Eng. Part C, 24, 56-67 (2018).



2017年
Toshiyuki Kida, Shin-ichiro Sato, Mitsuru Akashi, Supramolecular Cyclodextrin Microstructures as Novel Templates to Fabricate Hollow Polymer Cubes, Chem. Lett., 46, 1616-1619 (2017).

Hirokazu Narita, Fumiaki Shima, Junya Yokoyama, Shigeru Miyagawa, Yoshinari,Tsukamoto, Yasushi Takamura, Ayami Hiura, Ken Fukumoto, Tomohiro Chiba, Seiji,Watanabe, Yoshiki Sawa, Mitsuru Akashi, Hiroshi Shimoda, Engraftment and morphological development of vascularized human iPS cell-derived 3D-cardiomyocyte tissue after xenotransplantation, Sci. Rep., 7, 13708 (2017).

Yoshiya Asano, Tadashi Odagiri, Hiroe Oikiri, Michiya Matsusaki, Mitsuru Akashi, Hiroshi Shimoda, Construction of Artificial Human Peritoneal Tissue by Cell-Accumulation Technique and Its Application for Visualizing Morphological Dynamics of Cancer Peritoneal Metastasis, Biochem. Biophys. Res. Commun., 494, 213-219 (2017).

Nalinthip Chanthaset, Yoshikazu Takahashi, Yoshiaki Haramiishi, Mitsuru Akashi, Hiroharu Ajiro, Control of Thermoresponsivity of Biocompatible Poly(trimethylene carbonate) with Direct Introduction of Oligo(ethylene glycol) under Various Circumstances, J. Polym. Sci. Part A: Polym. Chem., 55, 3466-3474 (2017).

Tomofumi Uto, Takami Akagi, Masaaki Toyama, Mitsuru Akashi, Masanori Baba, Induction of Innate and Adaptive Immunity with Polyion Complex Nanoparticle Adjuvant Carrying Human Immunodeficiency Virus Type-1 gp120, J. Biomed. Nanotechnol., 13, 848-857 (2017).

Yoshinari Tsukamoto, Takami Akagi, Fumiaki Shima, Mitsuru Akashi, Fabrication of Orientation-Controlled 3D Tissues Using a Layer-by-Layer Technique and 3D Printed a Thermoresponsive Gel Frame, Tissue Eng. Part C Methods, 23, 357-366 (2017).

Shinya Fujishiro, Kai Kan, Mitsuru Akashi, Hiroharu Ajiro, Stability of Adhesive Interfaces by Stereocomplex Formation of Polylactides and Hybridization with Nanoparticles, Polym. Degrad. Stab., 141, 69-76 (2017).

Yoshiya,Asano ,Hiroshi Shimoda,Daisuke Okano,Michiya Matsusaki,Mitsuru Akashi,Transplantation of three-dimensional artificial human vascular tissues fabricated using an extracellular matrix nanofilm-based cell-accumulation technique.J. Tissue Eng. Reg. Med., ,11,1303-1307(2017)

Steffen Seitz, Mitsuru Akashi, Hiroharu Ajiro,“Pentaerythritol Particles Covered by Layer-by-Layer Self Assembled Thin Films with Stereocomplex of isotactic Poly(methyl methacrylate) and syndiotactic Poly(methyl methacrylate)”Colloid Polym. Sci., 295,1541-1548(2017).

Tom J. Phillips, Hannah Scott, David A. Menassa, Ashleigh L. Bignell, Aman Sood, Jude S. Morton, Takami Akagi, Koki Azuma, Mark F. Rogers, Catherine E. Gilmore, Gareth J. Inman, Simon Grant, Yealin Chung, Mais M. Aljunaidy, Christy-Lynn Cooke, Bruno R. Steinkraus, Andrew Pocklington, Angela Logan, Gavin P. Collett, Helena Kemp, Peter A. Holmans, Michael P. Murphy, Tudor A. Fulga, Andrew M. Coney, Mitsuru Akashi, Sandra T. Davidge, C. Patrick Case, Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development, Sci. Rep., 7, 9079 (2017).

Michiya Matsusaki, Misaki Komeda, Simona Mura, Hiroyoshi Tanaka, Mitsunobu R. Kano, Patrick Couvreur, and Mitsuru Akashi, Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability, Adv. Healthcare Mater., 6,1700057(2017).

Takami Akagi, Mayuka Nagura, Ayami Hiura, Hajime Kojima, Mitsuru Akashi, Construction of three-dimensional dermo-epidermal skin equivalents using cell coating technology and their utilization as alternative skin for permeation studies and skin irritation tests,Tissue Eng. Part A,(11-12):481-490.2017.

Kazuki Sasaki, Takami Akagi, Tadafumi Asaoka, Hidetoshi Eguchi, Yasunari Fukuda, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Koichi Kawamoto, Yuichiro Doki, Masaki Mori, Mitsuru Akashi, Construction of three-dimensional vascularized functional human liver tissue using a layer-by-layer cell coating technique, Biomaterials,133,263-274,(2017).

Asuka Kato, Kai Kan, Hiroharu Ajiro, Mitsuru Akashi, Development of a rapid in vitro tissue deadhesion system using the thermoresponsive sol-gel transition of hydroxybutyl chitosan. J. Biomater. Sci. Polymer Edn., 1-16 (2017).

Fumiaki Shima, Hirokazu Narita, Ayami Hiura, Hiroshi Shimoda, Mitsuru Akashi, Construction and histological analysis of a 3D human arterial wall model containing vasa vasorum using a layer-by-layer technique, J. Biomed. Mater. Res. A, 105A, 814-823 (2017).

Hang Thi Tran, Hiroharu Ajiro, Yi-Ju Hsiao, Mitsuru Akashi, Thermally resistant polylactide layer-by-layer film prepared using an inkjet approach”, Polym. J., 49, 327-334 (2017).

Hiroharu Ajiro, Kai Kan, Mitsuru Akashi, Thermal Treatment of Poly(N-vinylformamide) Produced Hydrogels without the Use of Chemical Crosslinkers, J. Nanosci. Nanotechnol., 17, 837-841 (2017).



2016年
Kai Kan, Michiya Fujiki, Mitsuru Akashi, Hiroharu Ajiro, Near-Ultraviolet Circular Dichroism of Achiral Phenolic Termini Induced by Nonchromophoric Poly(l,l-lactide) and Poly(d,d-lactide), ACS Macro Lett., 5 , 1014–1018 (2016).

Koji Matsuura, Ikuyo Sugimoto, Yuka Kuroda, Koji Kadowaki, Michiya Matsusaki, Mitsuru Akashi, Development of Microfluidic Systems for Fabricating Cellular Multilayers, Anal. Sci .32, 1-6 (2016).

Wanpen Tachaboonyakiat, Hiroharu Ajiro, Mitsuru Akashi, Controlled DNA Interpolyelectrolyte Complex Formation or Dissociation via Stimuli-Responsive Poly(vinylamine-co-N-vinylisobutylamide), J. Appl. Polym. Sci., 133, 43852 (2016).

Yoshiaki Haramiishi, Nalinthip Chanthaset, Kai Kan, Mitsuru Akashi, Hiroharu Ajiro, Contrast Effect on Hydrolysis of Poly(trimethylene carbonate) Depending on Accelerated Species Due To the Hydrophilic Oligo(ethylene glycol) Units at Side Groups, Polym. Degrad. Stab., 130, 78-82 (2016).

Aimin Ge, Michiya Matsusaki, Lin Qiao, Mitsuru Akashi, Shen Ye, Salt Effect on Surface Structures of Polyelectrolyte Multilayers (PEMs) Investigated by Vibrational Sum Frequency Generation (SFG) Spectroscopy, Langmuir, 32, 3803-3810 (2016).

Daichi Hikimoto, Akihiro Nishiguchi, Michiya Matsusaki, Mitsuru Akashi, High-Throughput Blood- and Lymph-Capillaries with Open-Ended Pores which allow the Transport of Drugs and Cells, Adv. Healthcare Mater., 5, 1969-1978 (2016).

Chun-Yen Liu, Michiya Matsusaki, Mitsuru Akashi, Control of Vascular Network Location in Millimeter-sized 3D-Tissues by Micrometer-sized Collagen Coated Cells, Biochem. Biophys. Res. Commun., 472, 131-136 (2016).

Paninee Chetprayoon, Michiya Matsusaki, Utako Yokoyama, T. Tejima, Yoshihiro Ishikawa, Mitsuru Akashi, Use of Three-dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery, Angew. Chem. Int. Ed., 128, 4537-4542 (2016).

Yuto Amano, Takuya Igarashi, Akihiro Nishiguchi, Michiya Matsusaki, Y. Saito, K. Nakamura, H. Ito, Mitsuru Akashi, Construction of mES Derived 3D-Pacemaker Tissues by Layer-by-Layer Nanofilm Coating, ChemNanoMat, 2, 466-471 (2016).

Yuto Amano, Akihiro Nishiguchi, Michiya Matsusaki, Hiroko Iseoka, Shigeru Miyagawa, Yoshiki Sawa, Manabu Seo, Takashi Yamaguchi, Mitsuru Akashi, Development of Vascularized iPSC Derived 3D-Cardiac Myoblast Tissues by Filtration Layer-by-Layer Technique and Their Application for Pharmaceutical Assays, Acta Biomater., 33, 110-121 (2016).

Hiroharu Ajiro, Yoshiaki Haramiishi, Nalinthip Chanthaset, Mitsuru Akashi, Polymer Design Using Trimethylene Carbonate with Ethylene Glycol Units for Biomedical Application, Polym. J., 5, 1969-1978 (2016).

Varvara Gribova, Chun-Yen Liu, Akihiro Nishiguchi, Michiya Matsusaki,Thomas Boudou, Catherine Picart, Mitsuru Akashi, Construction and myogenic differentiation of 3D myoblast tissues fabricated by fibronectin-gelatin nanofilm coating, Biochem. Biophys. Res. Commun., 474, 515-521 (2016).

Hiroharu Ajiro, Shogo Ito, Kai Kan, Mitsuru Akashi, Catechin Modified Polylactide Stereocomplex at Chain End Improved Antibiobacterial Property, Macromol. Biosci., 16, 694-704 (2016).

Heyun Shen, Takami Akagi, Mitsuru Akashi, Nanofiber Formation by the Self-assembly of Ampholyte Poly(amino acid), Chem. Lett., 45, 220-222 (2016).

Chun-Yen Liu, Michiya Matsusaki, Mitsuru Akashi, Three-dimensional Tissue Models Constructed by Cells with Nanometer- or Micrometer-Sized Films on Their Surfaces, Chem. Rec., 16, 783-796 (2016).

Noriyuki Uchida, Srikanth Sivaraman, Nicholas J. Amoroso, William R. Wagner, Akihiro Nishiguchi, Michiya Matsusaki, Mitsuru Akashi, Jiro Nagatomi, Nanometer-Sized Extracellular Matrix Coating on Polymer-based Scaffold for Tissue Engineering, J. Biomed. Mater. Res. Part A, 104A, 94-103 (2016).

Kai Kan, Mitsuru Akashi, Hiroharu Ajiro, Polylactides bearing vanillin at chain end provided dual dynamic interactions: stereocomplex formation, and nanostructure control, Macromol. Chem. Phys., 217, 2679-2685 (2016).

Hiroharu Ajiro, Shun Takahama, Masashi Mizukami, Kai Kan, Mitsuru Akashi, Kazue Kurihara,Force Estimation on the Contact of Poly(L,L-lactide) and Poly(D,D-lactide) Surfaces Regarding Stereocomplex Formation, Langmuir, 32, 9501-9506 (2016).

Hiroharu Ajiro, Tatsuaki Ueyama, Mitsuru Akashi, Preparation of Macroporous Replica Particles Using Stereocomplex of isotactic Poly(methyl methacrylate) and syndiotactic Poly(methacrylic acid), Colloids Surf. A, 506, 338-343 (2016).

Ryo Kawatani, Kai Kan, Malcolm A. Kelland, Mitsuru Akashi, Hiroharu Ajiro, Remarkable Effect on Thermosensitive Behavior Regarding Alkylation at the Amide Position of Poly(N-vinylamide)s, Chem. Lett., 45, 589-591 (2016).



2015年
Shintaro Kawano, Toshiyuki Kida, Mitsuru Akashi, Hirofumi Sato, Motohiro Shizuma, and Daisuke Ono, Preparation of Pickering Emulsions through Interfacial Adsorption by Soft Cyclodextrin Nanogels, Beilstein J. Org. Chem. 11, 2355-2364 (2015).

Yoshiya Asano, Hiroshi Shimoda, Daisuke Okano, Michiya Matsusaki, Mitsuru Akashi, Transplantation of three-dimensional artificial vascular tissues fabricated using an extracellular matrix nanofilm-based cell-accumulation technique, J. Tissue Eng. Reg. Med., (4):1303-1307 (2015).

Hang Thi Tran, Hiroharu Ajiro, Mitsuru Akashi, “Thermal Stable Polylactides by Stereocomplex Formation and Both Terminal Conjugation with Bio-based Cinnamic Acid Derivativess”, RSC Adv., 5, 91423-91430 (2015).

Hiroharu Ajiro, Ayaka Kuroda, Kai Kan, Mitsuru Akashi, “Stereocomplex Film Using Triblock Copolymers of Polylactide and Poly(ethylene glycol) Retain Paxlitaxel on Substrates by Aqueous Inkjet System”, Langmuir, 31 (38), 10583-10589 (2015).

Nishiguchi, Akihiro, Matsusaki, Michiya, Akashi, Mitsuru, “Structural and Viscoelastic Properties of Layer-by-Layer ECM Nanofilms and Their Interactions with Living Cells”, ACS Biomater. Sci. Eng., 1 (9), 816-824 (2015).

Chun-Yen Liu, Michiya Matsusaki, Mitsuru Akashi, “Control of Cell-Cell Distance in Millimeter-Sized 3D-Tissues Constructed by Collagen Nanofiber Coating Techniques”, ACS Biomater. Sci. Eng., 1 (8), 639-645 (2015).

Yoshika Suzawa, Norihiko Kubo, Soichi Iwai, Yoshiaki Yura, hajime ohgushi, Mitsuru Akashi, “Biomineral/agarose composite gels facilitate osteogenic differentiation of mesenchymal stem cells”, Int. J. Mol. Sci., 16 (6), 14245-14258 (2015).

Aimin Ge, Qiling Peng, Lin Qiao, Nageshwar R. Yepuri, Tamim A. Darwish, Michiya Matsusaki, Mitsuru Akashi, Shen Ye, “Molecular Orientation of Organic Thin Films on Dielectric Solid Substrates: A Phase-sensitive Vibrational SFG Study”, Phys. Chem. Chem. Phys., 17, 18072-18078 (2015).

Michiya Matsusaki, Kumiko Fujimoto, Yuji Shirakata, Satoshi Hirakawa, Koji Hashimoto, Mitsuru Akashi, “Development of Full-Thickness Human Skin Equivalents with Blood and Lymph-like Capillary Networks by Cell Coating Technology”, J. Biomed. Mater. Res. Part A, 103A, 3386-3396 (2015).

Fumiaki Shima, Takami Akagi, Manami Shudo, Eiko Mochizuki, Tetsuya Tsuda, Susumu Kuwabata, Mitsuru Akashi, “Interaction between Living Cells and Polymeric Particles: Potential Application of Ionic Liquid for Evaluating the Cellular Uptake of Biodegradable Polymeric Particles Composed of Poly(amino acid)”, Polym. J., 47, 631-638 (2015).

Fumiaki Shima, Takami Akagi, Mitsuru Akashi, “Effect of hydrophobic side chains in the induction of immune responses by nanoparticle adjuvants consisting of amphiphilic poly(γ-glutamic acid)”, Bioconjugate Chem., 26, 890-898 (2015).

Sarekha Woranuch, Rangrong Yoksan, Mitsuru Akashi, “Ferulic Acid-coupled Chitosan: Thermal Stability and Utilization as an Antioxidant for Biodegradable Active Packaging Film”, Carbohydr. Polym., 115, 744-751 (2015).

Michiya Matsusaki, Daichi Hikimoto, Akihiro Nishiguchi, Koji Kadowaki, Kayoko Ohura, Teruko Imai, Mitsuru Akashi, “3D-Fibroblast Tissues Constructed by a Cell-Coat Technology Enhance Tight-Junction Formation of Human Colon Epithelial Cells”, Biochem. Biophys. Res. Commun., 457, 363-369 (2015) .

Chun-Yen Liu, Michiya Matsusaki, Mitsuru Akashi, “Cell Effects on the Formation of Collagen Triple Helix Fibers inside Collagen Gels or on Cell Surfaces”, Polymer J., 47, 391-399 (2015).

Paninee Chetprayoon, Michiya Matsusaki, Mitsuru Akashi, “Three-Dimensional Human Arterial Wall Models for In Vitro Permeability Assessment of Drug and Nanocarriers”, Biochem. Biophys. Res. Commun., 456, 392-397 (2015).

Hiroharu Ajiro, Kazuya Takemura, Mitsuru Akashi, “Surface Polyion Complex Gel with Poly(vinylphosphonic Acid) and Poly(N-Vinylamide)s”, J. Polym. Sci. Part A, Polym. Chem., 53, 562-566, (2015).

Akihiro Nishiguchi, Michiya Matsusaki, Mitsuru Akashi, “Cell-Cell Crosslinking by Bio-Molecular Recognition of Heparin-Based Layer-by-Layer Nanofilms”. Macromol. Biosci., 15, 312-317 (2015).

Tomofumi Uto, Takami Akagi, Mitsuru Akashi, Masanori Baba, “Induction of potent adaptive immunity by the novel polyion complex nanoparticles”, Clin. Vaccine Immunol., 22 (5), 578-585 (2015).

Yuki Noguchi, Toshiyuki Kida, Eiichi Kato, Kikuo Shimizu, and Mitsuru Akashi, “Effective Extraction of Radioactive Cesium from Various Pollutants with a Detergent Solution Including Mg2+ and K+”, Radiation safety management, 14 (1), 15-17 (2015).

Shintaro Kawano, Toshiyuki Kida, Kazuhiro Miyawaki, Yasunori Fukuda, Eiichi Kato, Takeshi Nakano, Mitsuru Akashi, “Adsorption Capability of Urethane-crosslinked Heptakis(2,6-di-O-methyl)-β-cyclodextrin Polymers towards Polychlorobiphenyls in Nonpolar Organic Media”, Polymer J., 47, 443-448 (2015).

Akihiro Nishiguchi, Michiya Matsusaki, Shigeru Miyagawa, Yoshiki Sawa, Mitsuru Akashi, “Dynamic Nano-Interfaces Enable Harvesting of Functional 3D-Engineered Tissues”, Adv. Healthcare Mater., 3, 1164-1168 (2015).

Chizuru Kogame, Toshiyuki Kida, Tomoko Fijiwara, Mitsuru Akashi, “Unique Cation Binding Capability of Cyclic Oligo(L-lactic acid) (L-COLA)”, Tetrahedron Lett., 56, 1675-1678 (2015).

Soichi Iwai, Hidetaka Shimizu, Yoshika Suzawa, Mitsuru Akashi, Yoshiaki Yura, “Hydroxyapatite agarose composite gels as a biochemical material for the repair of alveolar bone defects due to cleft lip and palate”, J. Oral. Maxillofac. Surg. Med. Pathol., 27, 637-644 (2015).

Atsushi Matsuzawa, Michiya Matsusaki, Mitsuru Akashi, “Construction of Three-Dimensional Liver Tissue Models by a Cell Accumulation Technique and Metabolic Function Maintenance in a Long-Term Culture without Medium Change”, J. Biomed. Mater. Res. Part A, 103, 1554-1564 (2015).



2014年
Yuka Yamagishi, Taisuke Masuda, Michiya Matsusaki, Mitsuru Akashi, Utako Yokoyama, Fumihito Arai, “Microfluidic perfusion culture system for multilayer artery tissue models”, Biomicrofluidics, 8, 064113 (2014).

Yuki Noguchi, Toshiyuki Kida, Eiichi Kato, Kikuo Shimizu, Mitsuru Akashi, “Development of Extraction Technique for Radioactive Cesium in Polluted Soil (written in Japanese)”, J. Environ. Chem., 24, 119-124 (2014)./ 野口祐樹,木田敏之,加藤栄一,清水喜久雄,明石 満, “汚染土壌からの放射性セシウム抽出技術の開発”, 環境化学, 24, 119-124 (2014).

Toshiyuki Kida, Shin-ichiro Sato, Hiroaki Yoshida, Ayumi Teragaki, Mitsuru Akashi, “1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as a novel and effective solvent to facilely prepare cyclodextrin-assembled materials”, Chem. Commun., 50, 14245-14248 (2014).

Paninee Chetprayoon, Fumiaki Shima, Michiya Matsusaki, Takami Akagi, Mitsuru Akashi, “Sustainable Release of Paclitaxel from Biodegradable Poly(gamma-glutamic acid) Nanoparticles for Treatment of Atherosclerosis”, Chem. Lett., 43, 1767-1769 (2014).

Hiroharu Ajiro, Mitsuru Akashi, “Rapid Photogelation of Amphiphilic Poly(N-vinylacetamide) Bearing Coumarin Moiety in Water and Organic Solvents”, Chem. Lett., 43, 1613-1615 (2014).

Johan S. Nilsson, Sissela Broos, Takami Akagi, Mitsuru Akashi, Ann Hermansson, Per Caye-Thomasen, Malin Lindstedt, Lennart Greiff, “Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo” Acta Oto-laryngologica, 134, 1034-1041 (2014).

Hiroaki Yoshida, Doris Klee, Martin Moller, Mitsuru Akashi, “Creation of Superhydrophobic Electrospun Nonwovens Fabricated from Naturally-Occurring Poly(amino acid) Derivatives”, Adv. Funct. Mater., 24, 6359-6364 (2014).

Hiroharu Ajiro, Tatsuaki Ueyama, Mitsuru Akashi, “Temperature Effect on Template Polymerization of Methacrylic Acid Using Stereocomplex Formation on Quartz Crystal Microbalance Substrates”, J. Polym. Sci. Part A, Polym. Chem., 52, 3032-3036 (2014).

Chun-Yen Liu, Michiya Matsusaki, Mitsuru Akashi, “The Construction of Cell-Density Controlled Three-Dimensional Tissues by Coating Micrometer-Sized Collagen Fiber Matrices on Single Cell Surfaces”, RSC Adv., 4, 46141 (2014).

Fumiaki Shima, Takami Akagi, Mitsuru Akashi, “Synthesis and Preparation of nanoparticles composed of amphiphilic poly(γ-glutamic acid) with different hydrophobic side chains and their potential of membrane disruptive activity”, Colloid Polym. Sci., 292, 2663-2671 (2014).

Seunghwan Ryu, Yui Hashizume, Mari Mishima, Ryuzo Kawamura, Masato Tamura, Hirofumi Matsui, Michiya Matsusaki, Mitsuru Akashi, Chikashi Nakamura, “Measurement of Cell Adhesion Force by Vertical Forcible Detachment Using an Arrowhead Nanoneedle and AFM”, Biochem. Biophys. Res. Commun., 451, 107-111 (2014).

Daniel J. Curtis, Aman Sood, Tom J. Phillips, Veronica H.L. Leinster, Akihiro Nishiguchi, Christopher Coyle, Lizeth Lacharme-Lora, Oliver Beaumont, Helena Kemp, Roberta Goodall, Leila Cornes, Michele Giugliano, Rocco A. Barone, Michiya Matsusaki, Mitsuru Akashi, Hiroyoshi Y. Tanaka, Mitsunobu Kano, Jennifer McGarvey, Nagaraj D. Halemani, Katja Simon, Robert Keehan, William Ind, Tracey Masters, Simon Grant, Sharan Athwal, Gavin Collett, Dionne Tannetta, Ian L. Sargent, Emma Scull-Brown, Xun Liu, Kristian Aquilina, Nicki Cohen, Jon D. Lane, Marianne Thoresen, Jon Hanley, Andrew Randall, C. Patrick Case, “Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions”, Exp. Neurol. 261, 386-395 (2014).

Fumiaki Shima, Takami Akagi, Tomofumi Uto, Mitsuru Akashi, “Hydrophobic effect of nanoparticles composed of amphiphilic poly(γ-glutamic acid) effects on the degradability of the encapsulated proteins”, Biomater. Sci., 2, 1419-1425 (2014).

Kazuya Takemura, Hiroharu Ajiro, Tomoko Fujiwara, Mitsuru Akashi, “Oil Gels with Chemically Cross-linked Copolymer of Trimethylene Carbonate Derivative and L-Lactide: Preparation and Stereocomplex Formation within Gels”, RSC Adv., 4, 33462-33465 (2014).

Shintaro Kawano, Toshiyuki Kida, Kazuhiro Miyawaki, Yuki Noguchi, Eiichi Kato, Takeshi Nakano, Mitsuru Akashi, “Cyclodextrin Polymers as Highly Effective Adsorbents for Removal and Recovery of Polychlorobiphenyls (PCBs) Contaminants in Insulating Oil”, Environ. Sci. Technol., 48, 8094-8100 (2014).

Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi, Tomoko Fujiwara, “Surface Control of Hydrophilicity and Degradability with Block Copolymers Composed of Lactide and Cyclic Carbonate Bearing Methoxyethoxyl Groups”, Polymer, 55, 3591-3598 (2014).

Dongjian Shi, Rongjin Liu, Fengduo Ma, Daoyong Chen, Mingqing Chen, Mitsuru Akashi, “Studies on Synthesis, Characterization, and Functionalization of Poly(3,4-dihydroxy-L-phenylalanine)”, Chem. Lett., 43, 959-961 (2014).

Yoshiya Asano, Akihiro Nishiguchi, Michiya Matsusaki, Daisuke Okano, Erina, Saito, Mitsuru Akashi, Hiroshi. Shimoda, “Ultrastructure of Blood and Lymphatic Vascular Networks in Three-dimensional Cultured Tissues Fabricated by ECM nanofilm-based Cell Accumulation Technique”, Microscopy, 63, 219-226 (2014).

Fumiaki Shima, Manami Shudo, Takami Akagi, Mitsuru Akashi, “Preparation of siRNA carrier based on boronic acid functionalized amphiphilic poly(γ-glutamic acid) nanoparticles”, Chem. Lett., 24, 840-842 (2014).

Toshiyuki Kida, Tomoya Ohta, Kenta Kondo, Mitsuru Akashi, “Fabrication of poly(vinyl alcohol)s (PVAs) nanotubes through the fusion of nanocapsules composed of PVAs multilayer films”, Polymer, 55, 2841-2847 (2014).

Akihiro Nishiguchi, Michiya Matsusaki, Yoshiya Asano, Hiroshi Shimoda, Mitsuru Akashi, “Effects of Angiogenic Factors and 3D-Microenvironments on Vascularization within Sandwich Cultures”, Biomaterials, 35, 4739-4748 (2014).

Ye Zhu, Takami Akagi, Mitsuru Akashi, "Self-assembling stereocomplex nanoparticles by enantiomeric poly(γ-glutamic acid)-poly(lactide) graft copolymers as a protein delivery carrier", Maromol. Biosci., 14, 576-587 (2014).

Yukie Takemoto, Hiroharu Ajiro, Mitsuru Akashi, “Amphiphilic Poly(N-vinylacetamide) Gels Strengthened with Swelling Solvent”, Macromol. Chem. Phys., 215, 384-390 (2014).

Fumiaki Shima, Bjoern Schulte, Helmut Keul, Martin Moeller, Mitsuru Akashi, “Preparation of Microparticles Composed of Amphiphilic Poly(γ-glutamic acid) by Hydrophobic Interaction”, Polymer J., 46, 184-188 (2014).

Takami Akagi, Ye Zhu, Fumiaki Shima, Mitsuru Akashi, "Biodegradable nanoparticles composed of enantiomeric poly(γ-glutamicacid)-graft-poly(lactide) copolymers as vaccine carriers for dominant induction of cellular immunity", Biomater. Sci., 2, 530-537 (2014).

Ryo Ishiwata, Utako Yokoyama, Michiya Matsusaki, Yoshiya Asano, Koji Kadowaki, Yasuhiro Ichikawa, Masanari Umemura, Takayuki Fujita, Susumu Minamisawa, Hiroshi Shimoda, Mitsuru Akashi, Yoshihiro Ishikawa, “Three-dimensional Multilayers of Smooth Muscle Cells as a New Experimental Model for Studies of Vascular Elastic Fiber Formation Studies”, Atherosclerosis, 233, 590-600 (2014).

Takami Akagi, Tomoko Fujiwara, Mitsuru Akashi, “Inkjet printing of layer-by-layer assembled poly(lactide) stereocomplex with encapsulated proteins”, Langmuir, 30, 1669-1676 (2014).

Giuseppe Tronci, Hiroharu Ajiro, Stephen J. Russell, David J. Wood, Mitsuru Akashi “Tuneable Drug-loading Capability of Chitosan Hydrogels with Varied Network Architectures” Acta Biomater., 10, 821-830 (2014).

Masahiro Matsumoto, Michiya Matsusaki, Mitsuru Akashi, “Preparation of Biodegradable Peptide Nanospheres with Hetero PEG Brush Surfaces”, Macromol. Biosci., 42, 142-150 (2014).

Haruyasu Asahara, Toshiyuki Kida, Takuya Iwamoto, Tomoaki Hinoue, and Mitsuru Akashi, “Kinetic Resolution of Primary Amines via Enantioselective N-Acylation with Acyl Chlorides in the Presence of Supramolecular Cyclodextrin Nanocapsules”, Tetrahedron, 70, 197-203 (2014).

Fumiaki Shima, Takami Akagi, Mitsuru Akashi, “The role of hydrophobicity in the disruption of erythrocyte membrane by nanoparticles composed of hydrophobically modified poly(γ-glutamic acid)”, J. Biomater. Sci. Polym. Ed., 25, 203-210 (2014).



2013年
Phassamon Piyapakorn, Takami Akagi, Mitsuru Akashi, “Stimuli-responsive unimer nanoparticles composed of poly(amino acid) derivatives as promising protein-mimetic drug carriers”, Chem. Lett., 42, 1534-1536 (2013).

Hiroharu Ajiro, Mitsuru Akashi “Interpenetrating Polymer Network Using Amphiphilic Poly(N-vinyl acetamide) and Poly(2-hydroxyethyl methacrylate) To Deactivate Phosphate Ester Compounds”, Chem. Lett., 42, 1540-1541 (2013).

Riki Toita, Kenshi Nakao, Atsushi Mahara, Tetsuji Yamaoka, Mitsuru Akashi, “Biodistribution of Vaccines Comprised of Hydrophobically-Modified Poly(γ-glutamic acid) Nanoparticles and Antigen Proteins using Fluorescence Imaging”, Bioorg. Med. Chem., 21, 6608-6615 (2013).

Fumiaki Shima, Tomofumi Uto, Takami Akagi, Masanori Baba, Mitsuru Akashi, “Size Effect of Amphiphilic Poly(γ-glutamic acid) Nanoparticles on Cellular Uptake and Maturation of Dendritic Cells In Vivo”, Acta Biomater., 9, 8894-8901 (2013).[Elected as Faculty of 1000.]

Fumiaki Shima, Takami Akagi, Tomofumi Uto, Mitsuru Akashi, “Manipulating the Antigen-Specific Immune Response by the Hydrophobicity of Amphiphilic Poly(γ-glutamic acid) Nanoparticles”, Biomaterials, 34, 9709-9716 (2013).

Haruyasu Asahara, Toshiyuki Kida, Tomoaki Hinoue, Mitsuru Akashi, “Cyclodextrin Host as a Supramolecular Catalyst in Nonpolar Solvents: Stereoselective Synthesis of (E)-3-Alkylideneoxindoles”, Tetrahedron, 69, 9428-9433 (2013).

Masumi Maegawa, Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi, “A Study on Template Effect Using Irregular Porous Isotactic Poly(methyl methacrylate) Films Constructed with Syndiotactic Rich Poly(methacrylic acid) and Isotactic Poly(methyl methacrylate)”, Polym. J., 45, 898-903 (2013).

Wanpen Tachaboonyakiat, Hiroharu Ajiro and Mitsuru Akashi, “Synthesis of a thermosensitive polycation by random copolymerization of N-vinylformamide and Nvinylbutyramide”, Polym. J., 45, 971-978 (2013).

Phassamon Piyapakorn, Takami Akagi, Masahiro Hachisuka, Tomoyuki Onishi, Hideki Matsuoka, Mitsuru Akashi, “Structural analysis of unimer nanoparticles composed of hydrophobized poly(amino acid)s”, Macromolecules, 46, 6187-6194 (2013).

Riki Toita, Yasukazu Kanai, Hiroshi Watabe, Kenshi Nakao, Seiichi Yamamoto, Jun Hatazawa, Mitsuru Akashi, “Biodistribution of 125I-labeled polymeric vaccine carriers after subcutaneous injection”, Bioorg. Med. Chem., 21, 5310-5315 (2013).

Hiroharu Ajiro, Yi-Ju Hsiao, Hang Thi Tran, Tomoko Fujiwara, Mitsuru Akashi, “Thermally Stabilized Poly(lactide)s Stereocomplex with Bio-based Aromatic Groups at Both Initiating and Terminating Chain Ends” Macromolecules, 46, 5150-5156 (2013).

Hiroharu Ajiro, Tomoaki Hinoue, Mitsuru Akashi, “Inkjet Approaches Contribute to Facile Isotactic Poly(Methyl)/Syndiotactic Poly(Methyl Methacrylate) Stereocomplex Surface Preparation”, Macromol. Chem. Phys., 214, 1590-1595 (2013).

Fumiaki Shima, Tomofumi Uto, Takami Akagi, Mitsuru Akashi, “Synergistic stimulation of antigen presenting cells via TLR by combining CpG ODN and poly(γ-glutamic acid)-based nanoparticles as vaccine adjuvants”, Bioconjugate Chem., 24, 926-933 (2013).

Atsushi Matsuzawa, Michiya Matsusaki, Mitsuru Akashi, “Effectiveness of Nanometer-sized Extracellular Matrix Layer-by-Layer Films Coated on Cell Membranes in Protecting the Cells from Physical Stress”, Langmuir, 29, 7362-7368 (2013).

Sho Shinohara, Takanori Kihara, Shinji Sakai, Michiya Matsusaki, Mitsuru Akashi, Masahito Taya, Jun Miyake, “Fabrication of in vitro three-dimensional multilayered blood vessel model using human endothelial and smooth muscle cells and high-strength PEG hydrogel”, J. Biosci. Bioeng., 116, 231-234 (2013).

Ye Zhu, Takami Akagi, Mitsuru Akashi, “Preparation and characterization of nanoparticles formed through stereocomplexation between enantiomeric poly(γ-glutamic acid)-graft-poly(lactide) copolymers”, Polymer J., 45, 560-566 (2013).

Masahiro Matsumoto, Michiya Matsusaki, Mitsuru Akashi, ”Safe Control of Construction-Deconstruction of High-Density PEG Brushes on the Surface of Peptide Nanospheres by Thermally-Induced Shrinkage of PEG-SS-PEG”, Chem. Lett., 42, 344-346 (2013).

Michiya Matsusaki, Kayo Sakaue, Koji Kadowaki, Mitsuru Akashi, “Three-dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing”, Adv. Healthcare Mater., 2, 534-539 (2013). [Elected as a frontispiece]

Shintaro Kawano, Toshiyuki Kida, Shusuke Takemine, Chisato Matsumura, Takeshi Nakano, Masaki Kuramitsu, Kenji Adachi, and Mitsuru Akashi, “Efficient Removal and Recovery of Perfluorinated Compounds from Water by Surface-Tethered β-Cyclodextrins on Polystyrene Particles”, Chem.Lett., 42, 392-394 (2013).

Hiroaki Yoshida, Michiya Matsusaki, and Mitsuru Akashi, “Multilayered Blood Capillary Analogs in Biodegradable Hydrogels for In Vitro Drug Permeability Assay”, Adv. Funct. Mater., 23, 1736-1742 (2013). [Elected as an inside cover]

Norihiko Mizuta, Koji Hattori, Yoshika Suzawa, Soichi Iwai, Tomohiro Matsumoto, Mika Tadokoro, Takayoshi Nakano, Mitsuru Akashi, Hajime Ohgushi, Yoshiaki Yura, “Mesenchymal stromal cells improve the osteogenic capabilities of mineralized agarose gels in a rat full-thickness cranial defect model”, J. Tissue Eng. Regen. Med., 7, 51-60 (2013).

Toshiyuki Kida, Takuya Iwamoto, Haruyasu Asahara, Tomoaki Hinoue, Mitsuru Akashi, Chiral Recognition and Kinetic Resolution of Aromatic Amines via Supramolecular Chiral Nanocapsules in Nonpolar Solvents, J. Am. Chem. Soc., 135, 3371-3374 (2013).

Tomofumi Uto, Masaaki Toyama, Yosuke Nishi, Takami Akagi, Fumiaki Shima, Mitsuru Akashi, Masanori Baba, “Uptake of biodegradable poly(γ-glutamic acid) nanoparticles and antigen presentation by dendritic cells in vivo”, Results Immunol., 3, 1-9 (2013).

Hong Chu, Hiroharu Ajiro, Yoshikazu Takahashi, Mingqing Chen, Mitsuru Akashi, “Nanoparticle Fabrication with Biodegradable Block Copolymer Composed of Hydrophilic Poly(trimethylene carbonate) Derivative and Hydrophobic Polylactide”, Chem. Lett. 42, 74-76 (2013).

Haruyasu Asahara, Takuya Iwamoto, Toshiyuki Kida, Mitsuru Akashi, “Unique Catalytic Effect of a Cyclodextrin Host on Photodimerization of Coumarin in Nonpolar Solvents”, Tetrahedron Lett., 54, 688-691 (2013).

Fumiaki Shima, Koshi Kawakami, Takami Akagi, Eiko Mochizuki, Tetsuya Tsuda, Susumu Kuwabata, Mitsuru Akashi, “Simple observation of the interaction between nanoparticles and cells by scanning electron microscopy employing ionic liquid”, Bull. Chem. Soc. Jpn., 86, 153-158 (2013).

Pei Cheng Chua, Malcolm A. Kelland, Hiroharu Ajiro, Fumika Sugihara, Mitsuru Akashi, “Poly(vinylalkanamide)s as Kinetic Hydrate Inhibitors: Comparison of Poly(N-vinylisobutyramide) with Poly(N-isopropylacrylamide)”, Energ. Fuel, 27, 183-188 (2013).

Mitsuru Yokota, Hiroharu Ajiro, Mitsuru Akashi, “Effect of Copolymerizing Fluorine-Bearing Monomers on the Relationship Among Internal Structure, Gas Permeability, and Transparency in Copolymer Networks Composed of Methacrylates and Siloxane Macromers”, J. Appl. Polym. Sci., 127, 535-543 (2013).

Mitsuru Yokota, Hiroharu Ajiro, Mitsuru Akashi, “Transmission Electron Microscopic Observations of the Multilevel Microstructure of Crosslinked Copolymers with Methacrylates and Siloxane Macromer by a Radically Polymerizable Tuning Approach”, J. Appl. Polym. Sci., 127, 3325-3332 (2013).



2012年
Suja E. George, Christopher T. Elliott, Declan P. McLaughlin, Philippe Delahaut, Takami Akagi, Mitsuru Akashi, Terence L. Fodey, “An investigation into the potential use of nanoparticles as adjuvants for the production of polyclonal antibodies to low molecular weight compounds”, Vet. Immunol. Immunopathol., 149, 46-53 (2012).

Shinji Sakuma, Shun Kanamitsu, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, and Mitsuru Akashi, “Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake”, Mol. Pharm., 9, 922-929 (2012).

Koji Kadowaki, Michiya Matsusaki, Mitsuru Akashi, “Control of Cellular Inflammation by Layer-by-Layer Nanofilms through Different Driving Forces”, Chem. Lett., 41, 523 (2012).

Amornrart. Lertworasirikul, Nu-om Choothong, Hiroaki Yoshida, Michiya Matsusaki, Toshiyuki Kida, Apirat Laobuthee, Mitsuru Akashi, “Investigation on Thermoresponsive Behavior of Biodegradable Poly(gamma-glutamic acid)-graft-L-Phenylalanine Ethyl Ester”, J. Polym. Sci. Part A: Polym. Chem., 50, 4823 (2012).

Junichi Sasaki, Takuya Matsumoto, Hiroshi Egusa, Michiya Matsusaki, Akihiro Nishiguchi, Takayoshi Nakano, Mitsuru Akashi, Satoshi Imazato, Hirofumi Yatani, “In vitro reproduction of endochondral ossification using a 3D mesenchymal stem cell construct”, Integrat. Biol., 1207 (2012).

Paninee Chetprayoon, Koji Kadowaki, Michiya Matsusaki, Mitsuru Akashi, “Survival and Structural Evaluations of Three-Dimensional Tissues Fabricated by Hierarchical Cell Manipulation Technique”, Acta Biomater., 9, 4698 (2012).

Shi Dongjian, Michiya Matsusaki, Chen Mingqing, Mitsuru Akashi, “Effect of Degree of Branching on Properties of Photosensitive Nanoparticles as Drug-Delivery Carriers”, Macromol. Chem. Phys., 213, 2157 (2012).

Toshiyuki Kida, Masataka Mouri, Kenta Kondo, and Mitsuru Akashi, “Controlled Release Using a Polymer Stereocomplex Capsule through the Selective Extraction and Incorporation of One Capsule Shell Component”, Langmuir., 28, 15378-15384 (2012).

Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi, Tomoko Fujiwara, “Polylactide Block Copolymers using Trimethylene Carbonate with Methoxyethoxy Side Groups for Dual Modifications on Hydrophilicity and Biodegradability”, Macromol. Biosci., 12, 1315-1320 (2012).

Hiroharu Ajiro, Chizuru Hongo, Masumi Maegawa, Daisuke Kamei, Sono Sasaki, Hiroaki Ogawa, Hiroyasu Masunaga, Yukie Takemoto, Kazuyuki Horie, Mitsuru Akashi, “Structural Nanospace Feature and Substrate Contribution to Maintaining Stable Porosity of Polymer Chain in Layer-by-layer Assembled isotactic Poly(methyl methacrylate) Films”, Macromolecules., 45, 7660-7663 (2012).

Toshiyuki Kida, Kenta Kondo, Mitsuru Akashi, “Fabrication of Nanofibers through a Unique Morphological Transformation of Poly(lactic acid) particles in Water”, Chem. Commun., 48, 2319-2321 (2012).

Takami Akagi, Tomoko Fujiwara, Mitsuru Akashi, “Rapid fabrication of polylactide stereocomplex using layer-by-layer deposition by inkjet printing”, Angew. Chem. Int. Ed., 51, 5493-5496 (2012).

Heyun Shen, Takami Akagi, Mitsuru Akashi, "Polyampholyte nanoparticles prepared by self-complexation of cationized poly(γ-glutamic acid)", Macromol. Biosci., 12, 1100-1105 (2012).

Shigefumi Okamoto, Sumiko Matsuoka, Nobuyuki Takenaka, Ahmad Haredy, Takeshi Tanimoto, Yasuyuki Gomi, Toyokazu Ishikawa, Takami Akagi, Mitsuru Akashi, Yoshinobu Okuno, Yasuko Mori, and Koichi Yamanishi, “Intranasal immunization with formalin-inactivated human influenza A whole-virion vaccine alone or split-virion vaccine with mucosal adjuvants show similar cross-protection”, Clin.Vaccine Immunol., 19, 979-990 (2012).

Sissela Broos, Linda C Sandin, Jenny Apel, Thomas H Totterman, Takami Akagi, Mitsuru Akashi, Carl A.K. Borrebaeck, Peter Ellmark, Malin Lindstedt, "Synergistic augmentation of CD40-mediated activation of antigen-presenting cells by amphiphilic poly(γ-glutamic acid) nanoparticles", Biomaterials, 33, 6230-6239 (2012).

Hiroharu Ajiro, Yi-Ju Hsiao, Tran Han Thi, Tomoko Fujiwara, Mitsuru Akashi, “Stereocomplex of poly(lactide)s with chain end modification: simultaneous resistances to melting and thermal decomposition”, Chem. Commun., 48, 8478-8480 (2012).

Mitsuru Yokota, Hiroharu Ajiro, Mitsuru Akashi, “The Role of Amide Groups in Vinyl Monomers Containing Siloxane Groups for Highly Oxygen Permeable Hydrogels”, Bull. Chem. Soc. J., 85, 584-591 (2012). [Editor’s Choice: Selected Paper]

Hiroharu Ajiro, Masumi Maegawa, Mitsuru Akashi, “Nanospace Preparation by Crosslinking Helical syndiotactic-Poly(methacrylic acid) in Acetonitrile/Water After Stereocomplexation”, J. Polym. Sci. Part A: Polym. Chem., 50, 1469-1476 (2012).

Hiroharu Ajiro, Klaus Beckerle, Jun Okuda, Mitsuru Akashi, “Layer-by-Layer Assembly of Partially Sulfonated Isotactic Polystyrene with Poly(vinylamine)” Langmuir, 28, 5372-5378 (2012).

Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi, “Thermosensitive Biodegradable Homopolymer of Trimethylene Carbonate Derivative at Body Temperature”, Macromolecules, 45, 2668-2674 (2012).

Mitsuru Yokota, Yuko Miwa, Hiroharu Ajiro, Mitsuru Akashi, “The Systematic Study on the Microstructure of Crosslinked Copolymers of Siloxane Macromonomer and Methacrylates by Changing Composition and Components”, Polym. J., 44, 301-305 (2012).

Yosuke Amemiya, Keiko Kawano, Michiya Matsusaki, Mitsuru Akashi, Noriyuki Nakamura, Chikashi Nakamura, Formation of nanofilms on cell surfaced to improve the insertion efficiency of a nanoneedle into cells, Biochem. Biophys. Res. Commun., 420, 662 (2012).

Takami Akagi, Phassamon Piyapakorn, Mitsuru Akashi, “Formation of unimer nanoparticles by controlling the self-association of hydrophobically modified poly(amino acid)s”, Langmuir 28, 5249-5256 (2012).

Shigefumi Okamoto, Hironori Yoshii, Masaaki Matsuura, Asato Kojima, Toyokazu Ishikawa, Takami Akagi, Mitsuru Akashi, Michiaki Takahashi, Koichi Yamanishi, Yasuko Mori, “Poly-γ-glutamic acid nanoparticles and aluminum adjuvant used as an adjuvant with a single dose of Japanese encephalitis virus-like particles provides effective protection from Japanese encephalitis virus”, Clin.Vaccine Immunol., 19, 17-22 (2012).

Hitomi Hosoya, Koji Kadowaki, Michiya Matsusaki, Horacio Cabral, Hiroshi Nishihara, Hideaki Ijichi, Kazuhiko Koike, Kazunori Kataoka, Kohei Miyazono, Mitsuru Akashi, Mitsunobu R. Kano, “Engineering Fibrotic Tissue in Pancreatic Cancer: A Novel Three-dimensional Model to Investigate Nanoparticle Delivery”, Biochem.Biophys. Res. Commun., 419, 32-37 (2012).

Michiya Matsusaki, Hiroharu Ajiro, Toshiyuki Kida, Takeshi Serizawa, Mitsuru Akashi, LbL Assembly Through Weak Interactions and Their Biomedical Applications, Adv.Mater., 24, 454-474 (2012).

Masaaki Omichi, Michiya Matsusaki, Ikuro Maruyama, Mitsuru Akashi,  “Improvement of Blood Compatibility on Polysulfone?Polyvinylpyrrolidone Blend Films as a ModelMembrane of Dialyzer by Physical Adsorption of Recombinant Soluble Human Thrombomodulin” J. Biomater. Sci.: Polymer Edn. 23, 593-608 (2012).

Hiroharu Ajiro, Mitsuru Akashi, “Radical Polymerization of Novel N-Substituted-N-vinylformamide Derivatives with Bulky Chiral Substituents”, J. Polym. Sci. Part A: Polym. Chem. 50, 134-141 (2012).

Michiya Matsusaki, Koji Kadowaki, Eijiro Adachi, Takeshi Sakura, Utako Yokoyama, Yoshihiro Ishikawa, Mitsuru Akashi, Morphological and Histological Evaluations of 3D-Layerd Blood Vessel Constructs Prepared by Hierarchical Cell Manipulation, J. Biomater. Sci. Polymer Edn., 23, 63-79 (2012).



2011年
Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi, “Interpenetrating Polymer Networks of Poly(N-vinylacetamide) and Stimuli Responsive Polymers Applied to Novel Amphiphilic Gel”, J. Nanosci. Nanotech., 11, 7047-7049 (2011).

Tomofumi Uto, Takami Akagi, Masaaki Toyama, Yosuke Nishi, Fumiaki Shima, Mitsuru Akashi, Masanori Baba,“Comparative activity of biodegradable nanoparticles with aluminum adjuvants: antigen uptake by dendriticcells and induction of immune response in mice”, Immunol. Lett. 140, 36-43 (2011).

Mitsuru Yokota, Naoki Shimoyama, Kazuhiko Fujisawa, Masataka Nakamura, Hiroharu Ajiro, Mitsuru Akashi, “Novel method for Surface Modification of Silicone Containing Hydrogel Using Addition Reaction”, Chem. Lett. 40(11), 1297-1299 (2011).

Mitsuru Yokota, Masataka Nakamura, Hiroharu Ajiro, Mitsuru Akashi, “Synthesis of a Novel Silicone Monomer Bearing Amide Groups to Improve Compatibility with Hydrophilic Vinyl Monomers”, Chem. Lett., 40,858-859 (2011).

Akihiro Nishiguchi, Hiroaki Yoshida, Michiya Matsusaki, and Mitsuru Akashi, “Rapid Construction of Three-dimensional Multilayered Tissues with Endothelial Tube Networks by the Cell-accumulation Technique” Adv. Mater., 23, 3506-3510 (2011).

Michiya Matsusaki, Suzuka Amemori, Koji Kadowaki, and Mitsuru Akashi, “Quantitative 3D-Analysis of Nitric Oxide Diffusion in a 3D-Artery Model Using Sensor Particle” Angew. Chem. Int. Ed., 50, 7557-7561 (2011).

Tran Hang Thi, Michiya Matsusaki, Hiroshi Hirano, Hiroaki Kawano, Yasuyuki Agari, and Mitsuru Akashi, “Mechanism of High Thermal Stability of Commercial Polyesters and Polyethers Conjugated with Bio-Based Caffeic Acid” J. Polym. Sci. Polym. Chem., 49, 3152 (2011).

Toshiyuki Kida, Takuya Iwamoto, Yoshinori Fujino, Norimitsu Tohnai, Mikiji Miyata, and Mitsuru Akashi,” Strong Guest Binding by Cyclodextrin Hosts in Competing Nonpolar Solvents and the Unique Crystalline Structure” Org. Lett., 13, 4570-4573 (2011).

Takashi Miura, Toshiyuki Kida, and Mitsuru Akashi "Recognition of Stereoregularity of Poly(methacrylic acid)s with γ -Cyclodextrin", Macromolecules, Macromolecules, 44, 3273-3729 (2011).

Keisuke Matsuo, Hayato Koizumi, Mitsuru Akashi, Shinsaku Nakagawa, Takuya Fujita, Akira Yamamoto, Naoki Okada, “Intranasal immunization with poly(γ-glutamic acid) nanoparticles entrappingantigenic proteins can induce potent tumor immunity” J. Control. Release, 152, 310?316 (2011).

Michiya Matsusaki, Ryotaro Amekawa, Masahiro Matsumoto, Yuji Tanaka, Akira Kubota, Kohji Nishida, Mitsuru Akashi, "Physical and Specific Crosslinking of Collagen Fibers by Supramolecular Nano-gelators" Adv.Mater., 23, 2957-2961 (2011).

Tomofumi Uto, Takami Akagi, Keisuke Yoshinaga, Masaaki Toyama, Mitsuru Akashi, Masanori Baba, “The induction of innate and adaptive immunity by biodegradable poly (γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway”, Baiomaterials, 32, 5206-5212 (2011).

Morin Ryu, Toru Nakazawa, Takami Akagi, Tatsuhide Tanaka, RyouWatanabe, Masayuki Yasuda,Noriko Himori, KazuichiMaruyama, Toshihide Yamashita, Toshiaki Abe, Mitsuru Akashi, Kohji Nishida “Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid) nanoparticles containing dexamethasone” Journal of Controlled Release, 151, 65-73(2011).

Takami Akagi, Fumiaki Shima, Mitsuru Akashi, “Intracellular degradation and distribution of protein-encapsulated amphiphilic poly (amino acid) nanoparticles”, Biomaterials, 32, 4959-4967 (2011).

Yuji Tanaka, Akira Kubota, Michiya Matsusaki, Thomas Duncan, Yoshikiyo Hatakeyama, Katsuya Fukuyama, Andrew J. Quantock, Masayuki Yamato, Mitsuru Akashi, Kohji Nishida, “Anisotropic Mechanical Properties of Collagen Hydrogels Induced by Uniaxial-flow for Ocular Applications”, J. Biomater. Sci. Polymer Edn., 22, 1427 (2011).

Daisuke Kamei, Hiroharu Ajiro, Mitsuru Akashi, “Fusion of Porous Isotactic Poly(methyl methacrylate) Thin Films Fabricated on Silica Nanoparticles with Stepwise Stereocomplex Assembly”, J. Nanosci. Nanotech., 11, 2545-2548 (2011).

Michiya Matsusaki, Masahiro Matsumoto, Tomonori Waku, Mitsuru Akashi, “Self-Assembled Structure of Peptide Nanospheres Induces High Stability against Hydrolysis and Sterilization”, J. Biomater. Sci. Polymer Edn., 22, 1035 (2011).

Donjian Shi, Michiya Matsusaki and Mitsuru Akashi, Photo-tunable Protein Release from Biodegradable nanoparticles Composed of Cinnamic Acid Derivatives, J. Control. Release 149, 182-189 (2011).

Heyun Shen, Junji Watanabe, Mitsuru Akashi “Polyelectrolyte multilayers-modified membrane filter for rapid immunoassay: protein condensation by centrifugal permeation”, Polym. J. 43, 35-40 (2011).



2010年
Yoshika Suzawa, Takafumi Funaki, Junji Watanabe, Soichi Iwai, Yoshiaki Yura, Takayoshi Nakano, Yukichi Umakoshi, Mitsuru Akashi, "Regenerative Behavior of Biomineral / Agarose Composite Gels as Bone Grafting Materials in Rat Cranial Defects", J. Biomed. Mater. Res. Part A., 93, 965-975 (2010).

Jun-Ichi Sasaki, Taka-Aki Asoh, Takuya Matsumoto, Hiroshi Egusa, Taiji Sohmura, Eben Alsberg, Mitsuru Akashi, Hirofumi Yatani, “Fabrication of 3D Cell Constructs Using Temperature-responsive Hydrogel”, Tissue Eng., 16, 2497-2504 (2010).

Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi, Pei Cheng Chua, Malcolm A. Kelland, “A Study of the Kinetic Hydrate Inhibitor Performance of a Series of Poly(N-vinylacetamide)s”, Energ. Fuel, 24, 6400-6410 (2010).

Koji Kadowaki, Michiya Matsusaki, Mitsuru Akashi, Three-dimensional Constructs Induce High Cellular Activity: Structural Stability and the Specific Production of Proteins and Cytokines, Biochem. Biophys. Res. Commun., 402, 153-157 (2010).

Hiroharu Ajiro, Mitsuru Akashi, “Cell Proliferation on Stereoregular Isotactic-Poly (propylene oxide) as a Bulk Substrate”, Biomacromolecules, 11, 2840-2844 (2010).

Toshiyuki Kida, Koichiro Kishimoto, Koji Hatano, Masahiro Muraoka, Yohji Nakatsuji, Mitsuru Akashi, "Acetylated Cyclodextrins as New Organogelators" Chem. Lett., 39, 1206-1208 (2010).

Masaaki Omichi, Michiya Matsusaki, Shinya Kato, Ikuro Maruyama, Mitsuru Akashi, “Enhancement of the Blood Compatibility of Dialyzer Membranes by the Physical Adsorption of Human Thrombomodulin (ART-123)”, J. Biomed. Mater. Res. Part:B, 95B, 291-297 (2010).

Akihiro Nishiguchi, Hiroaki Yoshida, Michiya Matsusaki and Mitsuru Akashi, “Preparation of Reduction-Sensitive Nanogels with a Large Swelling Capacity by a Surfactant-Free Precipitation Method”, Chem. Lett., 39, 1184-1185 (2010).

Tomonori Waku, Masahiro Matsumoto, Michiya Matsusaki, Mitsuru Akashi, “Complete Surface Control of Peptide Nanospheres with Detachable and Attachable Polymer Brush Layers”, Chem. Commun., 46, 7025-7027 (2010).

Hyungjin Kim, Tomofumi Uto, Takami Akagi, Masanori Baba, Mitsuru Akashi, “Amphiphilic poly(amino acid) nanoparticles induce size-dependent dendritic cell maturation”, Adv. Funct. Mater., 20, 3925?3931 (2010).

Daisuke Kamei, Hiroharu Ajiro, Mitsuru Akashi, “Specific Recognition of Syndiotactic Poly(methacrylic acid) in Porous Isotactic Poly(methyl methacrylate) Thin Films Based on the Effects of Stereoregularity, Temperature, and Solvent”, J. Polym. Sci. Part A: Polym. Chem., 48, 3651-3657 (2010).

Kenta Kondo, Toshiyuki Kida, Yuji Ogawa, Yuuya Arikawa, Mitsuru Akashi, “Nanotube Formation through the Continuous One-dimensional Fusion of Hollow Nanocapsules Composed of Layer-by-layer Poly(lactic acid)s Stereocomplex Films”, J. Am. Chem. Soc., 132, 8236-8237 (2010).

Shinji Sakuma, Yumi Teraoka, Tomokazu Sagawa, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Yusuke Ikumi, Toshiyuki Kida, Mitsuru Akashi, “Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake”, Eur. J. Pharm. Biopharm., 75, 366-374 (2010).

Yasuhiro Marui, Akira Kikuzawa, Toshiyuki Kida, Mitsuru Akashi, “Unique Organogel Formation with Macroporous Materials Constructed by the Freeze-drying of Aqueous Cyclodextrin Solutions”, Langmuir, 26, 11441-11445 (2010).

Ai Himeno, Takami Akagi, Tomofumi Uto, Xin Wang, Masanori Baba, Kentaro Ibuki, Megumi Matsuyama, Mariko Horiike, Tatsuhiko Igarashi, Tomoyuki Miura, Mitsuru Akashi, “Evaluation of the immune response and protective effects of rhesus macaques vaccinated with biodegradable nanoparticles carrying gp120 human immunodeficiency virus”, Vaccine, 28, 5377-5385 (2010).

Sissela Broos, Kristina Lundberg, Takami Akagi, Koji Kadowaki, Mitsuru Akashi, Lennart Greiff, Carl A.K. Borrebaeck, Malin Lindstedt, “Immunomodulatory Nanoparticles as Adjuvants and Allergen-delivery System to Human Dendritic Cells: Implications for Specific Immunotherapy”, Vaccine, 28, 5075-5085 (2010).

Yasuhiro Marui, Toshiyuki Kida, Mitsuru Akashi, “Facile Morphological Control of Cyclodextrin Nano- and Microstructures and their Unique Organogelation Ability”, Chem. Mater., 22, 282-284 (2010).

Hiroharu Ajiro, Masumi Maegawa, Mitsuru Akashi, “Thermal Stability of Porous it-PMMA Thin Film Obtained by the Extraction of st-PMAA from it-PMMA/st-PMAA Stereocomplex with Layer-by-layer Assembly on Substrate”, J. Polym. Sch. Part A: Polym. Chem., 48, 3265-3270 (2010).

Yukie Takemoto, Hiroharu Ajiro, Taka-aki Asoh, Mitsuru Akashi, “Fabrication of Surface-Modified Hydrogels with Polyion Complex for Controlled Release”, Chem. Mater., 22, 2923-2929 (2010).

Takayuki Hamasaki, Tomofumi Uto, Takami Akagi, Mitsuru Akashi, Masanori Baba, “Modulation of Gene Expression Related to Toll-Like Receptor Signaling in Dendritic Cells by Poly(γ-Glutamic Acid) Nanoparticles”, Clin. Vaccine Immunol., 17, 748-756 (2010).

Hiroharu Ajiro, Mitsuru Akashi, “Nano Grape Formation by isotactic-Poly(methacrylic acid)-block-poly(butyl acrylate)”, Macromol. Rapid Commun., 31, 714-717 (2010).

Koji Kadowaki, Michiya Matsusaki, Mitsuru Akashi, “Control of Cell Surface and Functions by Layer-by-Layer Nanofilms”, Langmuir, 26, 5670-5678 (2010).

Daisuke Kamei, Hiroharu Ajiro, Mitsuru Akashi, “Morphological Changes of Isotactic Poly(methyl methacrylate) Thin Films via Self-organization and Stereocomplex Formation”, Polym. J., 42, 131-137 (2010).

Michiya Matsusaki, Masaaki Omichi, Koji Kadowaki, Bong Hoon Kim, Sang Ouk Kim, Ikuro Maruyama, Mitsuru Akashi, “Protein Nanoarrays on a Highly-Oriented Lamellar Surface”, Chem. Commun., 46, 1911-1913 (2010).

Takayuki Imoto, Toshiyuki Kida, Michiya Matsusaki, Mitsuru Akashi, “Preparation and Unique pH-Responsive Properties of Novel Biodegradable Nanocapsules Composed of Poly(gamma-glutamic acid) and Chitosan as Weak Polyelectrolytes”, Macromol. Biosci., 10, 271-277 (2010).

Hyungjin Kim, Takami Akagi, Mitsuru Akashi, “Preparation of CpG ODN-encapsulated Anionic Poly(amino acid) Nanoparticles for Gene Delivery”, Chem. Lett., 39, 278-279 (2010).

Shinjiro Yamaguchi, Tomohide Tatsumi, Tetsuo Takehara, Akira Sasakawa, Masashi Yamamoto, Keisuke Kohga, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Takami Akagi, Mitsuru Akashi, Norio Hayashi, “EphA2 Derived Peptide Vaccine with Amphiphilic Poly(γ-glutamic acid) Nanoparticles Elicits Antitumor Effect against Mouse Liver Tumor”, Cancer Immunol. Immunother., 59, 759-767 (2010).

Hiroaki Yoshida, Michiya Matsusaki, Mitsuru Akashi, “Development of Thick and Highly Cell-Incorporated Engineered Tissues by Hydrogel Template Approach with Basic Fibroblast Growth Factor or Ascorbic Acid, J. Biomater. Sci. Polymer Edn., 21, 415-428 (2010).

Takami Akagi, Hyungjin Kim, Mitsuru Akashi, “pH-dependent Disruption of Erythrocyte Membrane by Amphiphilic Poly(amino acid) Nanoparticles”, J. Biomater. Sci. Polym. Edn., 21, 315-328 (2010).

Hiroharu Ajiro, Chizuru Hongo, Mitsuru Akashi, “Design and synthesis of N-vinylacetamide Derivative with Bulky Group by Nucleophilic Substitution Reaction”, J. Mol. Struct., 964, 67-71 (2010).

Suzuka Amemori, Michiya Matsusaki, Mitsuru Akashi, “Biocompatible and Highly-sensitive Nitric Oxide Sensor Particles Prepared by Layer-by-layer Assembly”, Chem. Lett., 39, 42-43 (2010).

Takami Akagi, Kazuki Watanabe, Hyungjin Kim, Mitsuru Akashi, “Stabilization of Polyion Complex Nanoparticles Composed of Poly(amino acid) Using Hydrophobic Interactions”, Langmuir, 26, 2406-2413 (2010).



2009年
Dongjian Shi, Xiaoya Liu, Fei Xiang, Mingqing Chen, Cheng Yang, Mitsuru Akashi, “Studies on Preparation and Fluorescent Properties of a Novel Photo-Sensitive Nanoparticle Composed of Europium Ion and Cinnamic Acid Derivative”, Macromol. Chem. Phys., 210, 2063-2069 (2009).

Toshiyuki Kida, Yoshinori Fujino, Kazuhiro Miyawaki, Eiichi Kato, Mitsuru Akashi, "6-O-Modified beta-Cyclodextrin Enabling Inclusion Complex Formation in Nonpolar Media," Org. Lett., 11, 5282-5285 (2009).

Tran Hang Thi, Michiya Matsusaki, Mitsuru Akashi, “Photoreactive Polylactide Nanoparticles by the Terminal Conjugation of Bio-based Caffeic Acid”, Langmuir, 25, 10567-10574 (2009).

Dongjian Shi, Michiya Matsusaki, Mitsuru Akashi, “Photo-Crosslinking Induces Size Change and Stealth Properties of Water-Dispersible Cinnamic Acid Derivative Nanoparticles”, Bioconjugate Chem., 20, 1917-1923 (2009).

Shigefumi Okamoto, Masaaki Matsuura, Takami Akagi, Mitsuru Akashi, Takeshi Tanimoto, Toyokazu Ishikawa, Michiaki Takahashi, Koichi Yamanishi, Yasuko Mori, “Poly (γ-Glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice, Vaccine, 27, 5896-5905 (2009).

Toshiyuki Kida, Yasuhiro Marui, Kazuhiro Miyawaki, Eiichi Kato, Mitsuru Akashi, “Unique organogel formation with a channel-type cyclodextrin assembly”, Chem. Commun., 3889-3891 (2009).

Heyun Shen, Junji Watanabe, Mitsuru Akashi, “Polyelectrolyte Multilayers-Modified Polystyrene Plate Improves Conventional Immunoassay: Full Covering of the Blocking Reagent”, Anal. Chem., 81, 6923-6928 (2009).

Hyungjin Kim, Takami Akagi, Mitsuru Akashi, “Preparation of size tunable amphiphilic poly(amino acid) nanoparticles”, Macromol. Biosci., 9, 825-932 (2009).

Junji Watanabe, Mitsuru Akashi, “Dual Mineralization of Dicalcium Phosphate and Hydroxyapatite Formation on Both Sides of Porous Membrane: Alternating Current Induces pH-Modulated Crystal Deposition”, J. Crystal Growth, 311, 4323-4328 (2009).

Tomofumi Uto, Takami Akagi, Takayuki Hamasaki, Mitsuru Akashi, Masanori Baba, “Modulation of innate and adaptive immunity by biodegradable nanoparticles”, Immunology Letters, 125, 46-52 (2009).

Junji Watanabe, Kenji Kano, Mitsuru Akashi, “Bioconjugate Polymer by Photo-Iniferter Approach: Hydrophilic Random or Block Copolymer-Coated Surface”, Mater. Sci. Eng. C, 29, 2287-2293 (2009).

Hiroharu Ajiro, Yukie Takemoto, Taka-aki Asoh, Mitsuru Akashi, “Novel Polyion Complex with Interpenetrating Polymer Network of Poly(acrylic acid) and Partially Protected Poly(vinylamine) Using N-Vinylacetamide and N-Vinylformamide”, Polymer, 50, 3503-3507 (2009).

Junji Watanabe, Mitsuru Akashi, “Formation of Various Polymorphs of Calcium Carbonate on Porous Membrane by Electrochemical Approach”, J. Crystal Growth, 311, 3697-3701 (2009).

Heyun Shen, Junji Watanabe, Mitsuru Akashi, “Heterofunctional Interfaces Achieve Dual Protein Adsorption on Polyelectrolyte Multilayers”, Polym. J., 41, 486-491 (2009).

Tran Hang Thi, Michiya Matsusaki, Mitsuru Akashi, “Development of Photoreactive Degradable Branched Polyesters with High Thermal and Mechanical Properties”, Biomacromolecules, 10, 766-772 (2009).

Taka-aki Asoh, Mitsuru Akashi, “Hydrogel Logic Gates Using Gradient Semi-IPNs”, Chem. Commun., 3548-3550 (2009).

Hiroaki Yoshida, Kristina Klinkhammer, Michiya Matsusaki, Martin Moeller, Doris Klee, Mitsuru Akashi, “Disulfide-Crosslinked Electrospun Poly(γ-glutamic acid) Non-wovens as Reduction-responsive Scaffolds”, Macromol. Biosci., 9, 568-574 (2009).

Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi, “Mechanistic Studies on Template Polymerization in Porous isotactic-Poly(methyl methacrylate) Thin Films by Radical Polymerization and Postpolymerization of Methacrylate Derivatives”, Macromolecules, 42, 3019-3025 (2009).

Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi, “Interpenetrating Polymer Networks of Poly(N-vinylacetamide) and Poly(acrylic acid) Applied to a Novel Amphiphilic Drug Release Substrates with Mechanically Modified Strengths”, Chem. Lett., 38, 368-369 (2009).

Junji Watanabe, Mitsuru Akashi, “Effect of an alternating current for crystallization of CaCO3 on a porous membrane”, Acta Biomaterialia, 5, 1306-1310 (2009).

Junji Watanabe, Heyun Shen, Mitsuru Akashi, “Alternate Drop Coating for Forming Dual Biointerfaces Composed of Polyelectrolyte Multilayers”, J. Mater. Sci.: Mater. Med., 20, 759-765 (2009).

Dongjian Shi, Michiya Matsusaki, Mitsuru Akashi, “Unique Size-Change Behavior of Photo-Crosslinked Cinnamic Acid Derivative Nanoparticles during Hydrolytic Degradation”, Macromol. Biosci., 9, 248-255 (2009).

Hiroaki Yoshida, Michiya Matsusaki, Mitsuru Akashi, “Scaffold-Mediated 2D-Cellular Orientations for Construction of 3D-Engineered Tissues Composed of Oriented Cells and ECM”, Adv. Funct. Mater., 19, 1001-1007 (2009).

Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi, “Macroporous Silicagel Substrate for Stereoregular Template Polymerization of Methacrylic Acid Using Stereocomplex Assembled Thin Films”, Polym. J., 41, 90-93 (2009).

Hiroharu Ajiro, Mitsuru Akashi, “Radical Polymerization of Novel N-Substituted-N-vinylacetamides and Regulated Polymer Structures by Bulky Substituents and Menthol Coordination”, Macromolecules, 42, 489-493 (2009).

Daisuke Kamei, Hiroharu Ajiro, Chizuru Hongo, Mitsuru Akashi, “Solvent Effects on Isotactic Poly(methyl methacrylate) Crystallization and Syndiotactic Poly(methacrylic acid) Incorporation in Porous Thin Films Prepared by Stepwise Stereocomplex Assembly”, Langmuir, 25, 280-285 (2009).

Michiya Matsusaki, Koji Kadowaki, Kosuke Tateishi, Chikahisa Higuchi, Wataru Ando, David A. Hart, Yoshinari Tanaka, Yasuhiro Take, Mitsuru Akashi, Hideki Yoshikawa, Norimasa Nakamura, “Scaffold-Free Tissue Engineered Construct-Hydroxyapatite Composites Generated by an Alternate Soaking Process: Potential for Repair of Bone Defects”, Tissue Eng., 15, 55-63 (2009).

Tomofumi Uto, Xin wang, Takami Akagi, Rika Zenkyu, Mitsuru Akashi, Masanori Baba, “Improvement of adaptive immunity by antigen-carrying biodegradable nanoparticles”, Biochemical and Biophysical Research Communications, 379, 600-604 (2009).

Shinji Sakuma, Tomokazu Sagawa, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Yusuke Ikumi, Toshiyuki Kida, Mitsuru Akashi, “Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(γ-glutamic acid)”, J. Control. Release, 133, 125-131(2009).

Rangrong Yoksan, Mitsuru Akashi, “Low molecular weight chitosan-g-L-phenylalanine: Preparation, characterization, and complex formation with DNA”, Carbohydrate Polymers, 75, 95-103 (2009).



2008年
Hong Chu, Wei Yang, Mingqing Chen, Jianyan Liu, Dongjian Shi, Mitsuru Akashi, “Preparation of core-shell mircospheres by ATRP synthesized macromonomer”, Chinese J. Chem., 26, 1907-1912 (2008).

Tran Hang Thi, Michiya Matsusaki, Mitsuru Akashi, “Thermally Stable and Photoreactive Polylactides by the Terminal Conjugation of Bio-based Caffeic Acid”, Chem. Commun., 3918-3920 (2008).

Junji Watanabe, Mitsuru Akashi, “Anisotropic Hydroxyapatite Formation inside Agarose Gels by Integration of Electrophoretic and Alternate Soaking Approaches”, J. Biomater. Sci. Polym. Edn., 19, 1625?1635 (2008).

Tomonori Waku, Michiya Matsusaki, Suwabun Chirachanchai, Mitsuru Akashi, “One-Step Preparation of Cationic Sugar-Peptide Nanospheres Using The Water-soluble Chitosan-initiated Polymerization of L-Phenylalanine N-Carboxyanhydride”, Chem. Lett., 37, 1262-1263 (2008).

Chizuru Hongo, Michiya Matsusaki, Kohji Nishida, Mitsuru Akashi, “Development of a Collagen Hydrogel with High Mechanical Strength by a Simple Molecular Orientation Method for Triple-Helix”, Chem. Lett., 37, 1254-1255 (2008).

Toshiyuki Kida, Akira Kikuzawa, Mitsuru Akashi, “Formation of Inclusion Complexes of Isotactic and Syndiotactic Poly(methyl methacrylate)s with ?-Cyclodextrin”, Chem. Lett., 37, 1120-1121 (2008).

Dongjian Shi, Michiya Matsusaki, Tatsuo Kaneko, Mitsuru Akashi, “Photo-Crosslinking and Cleavage Induced Reversible Size Change of Bio-Based Nanoparticles”, Macromolecules, 41, 8167-8172 (2008).

Junji Watanabe, Mitsuru Akashi, “Controlled Deposition of Calcium Carbonate Particles on Porous Membranes by using Alternating Current System”, J. Colloid Interface Sci., 327, 44-50 (2008).

Junji Watanabe, Mitsuru Akashi, “Integration Approach for Developing a High-Performance Biointerface: Sequential Formation of Hydroxyapatite and Calcium Carbonate by an Improved Alternate Soaking Process”, Appl. Surf. Sci., 255, 344-349 (2008).

Toshiyuki Kida, Takashi Minabe, Suguru Nakano, Mitsuru Akashi, “Fabrication of Novel Multilayered Thin Films Based on Inclusion Complex Formation between Amylose Derivatives and Guest Polymers”, Langmuir, 24, 9227-9229 (2008).

Amornrat Lertworassirikul, Yuya Arikawa, Tatsuo Kaneko, Toshiyuki Kida, Mitsuru Akashi, “Preparation of Flexible and Transparent Polylactic Acids Films by Crystallization Manipulation”, J. Polym. Sci. Part A: Polym. Chem., 46, 6489-6495 (2008).

Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi, “Methacrylic Acid and Methyl Methacrylate Oligomers Adsorbed to Porous isotactic Poly(methyl methacrylate) Ultrathin Filims and Mechanistic Studies of Living Template Polymerization”, J. Polym. Sci. Part A: Polym. Chem., 46, 5879-5886 (2008).

Junji Watanabe, Suzuka Amemori, Mitsuru Akashi, “Disparate Polymerization Facilitates the Synthesis of Versatile Block Copolymers from Poly(trimethylene carbonate)”, Polymer, 49, 3709-3715 (2008).

Yuji Ogawa, Yuya Arikawa, Toshiyuki Kida, Mitsuru Akashi, “Fabrication of Novel Layer-by-Layer Assembly Films Composed of Poly(lactic acid) and Polylysine through the Cation-Dipole Interactions”, Langmuir, 24, 8606-8609 (2008).

Yuki Itoh, Michiya Matsusaki, Toshiyuki Kida, Mitsuru Akashi, “Locally Controlled Release of Basic Fibroblast Growth Factor from Multilayered Capsules”, Biomacromolecules, 9, 2202-2206 (2008).

Junji Watanabe, Heyun Shen, Mitsuru Akashi, “Polyelectrolyte Droplet Facilitates Versatile Layer-by-Layer Coating for Protein Loading Interface”, Acta Biomaterialia, 4, 1255-1262 (2008).

Hiroharu Ajiro, Junji Watanabe, Mitsuru Akashi, “Cell Adhesion and Proliferation on Poly(N-vinylacetamide) Hydrogels and Double Network Approach for Changing Cellular Affinities”, Biomacromolecules, 9, 426-430 (2008).

Toshiyuki Kida, Takeshi Nakano, Yoshinori Fujino, Chisato Matsumura, Kazuhiro Miyawaki, Eiichi Kato, Mitsuru Akashi, “Complete Removal of Chlorinated Aromatic Compounds from Oils by Channel-Type β-Cyclodextrin Assembly”, Anal. Chem., 80, 317-320 (2008).

Taka-aki Asoh, Michiya Matsusaki, Tatsuo Kaneko, Mitsuru Akashi, “Fabrication of Temperature-Responsive Bending Hydrogels with a Nanostructured Gradient”, Adv. Mater., 20, 2080-2083 (2008).

Yuki Itoh, Michiya Matsusaki, Toshiyuki Kida, Mitsuru Akashi, “Time-modulated Release of Multiple Proteins from Enzyme-responsive Multilayered Capsules”, Chem. Lett., 37, 238-239 (2008).

Daisuke Kamei, Hiroharu Ajiro, Chizuru Hongo, Mitsuru Akashi, “Dynamics of Polymer Chains in Porous Thin Films Prepared by Layer-by-Layer Assembly of Isotactic Poly(methyl methacrylate) and Syndiotactic Poly(methacrylic acid)”, Chem. Lett., 37, 332-333 (2008).

Junji Watanabe, Mitsuru Akashi, “An Electrophoretic Approach Provides Tunable Mineralization inside Agarose Gels”, Crystal Growth & Design, 8, 478-482 (2008).

Tomoaki Yoshikawa, Naoki Okada, Atsushi Oda, Keisuke Matsuo, Kazuhiko Matsuo, Hiroyuki Kayamuro, Yumiko Ishii, Tomoyo Yoshinaga, Takami Akagi, Mitsuru Akashi, Shinsaku Nakagawa, “Nanoparticles built by self-assembly of amphiphilicγ-PGA can deliver antigens to antigen-presenting cells with high efficiency: A new tumor-vaccine carrier for eliciting effector T cells”, Vaccine, 26, 1303-1313 (2008).

Shigefumi Okamoto, Hironori Yoshii, Toyokazu Ishikawa, Takami Akagi, Mitsuru Akashi, Michiaki Takahashi, Koichi Yamanishi, Yasuko Mori, “Single dose of inactivated Japanese encephalitis vaccine with poly(γ-glutamic acid) nanoparticles provides effective protection from Japanese encephalitis virus”, Vaccine, 26, 589-594 (2008).

Tomoaki Yoshikawa, Naoki Okadam Atsushi Oda, Kazuhiko Matsuo, Keisuke Matsuo, Yohei Mukai, Yasuo Yoshioka, Takami Akagi, Mitsuru Akashi, Shinsaku Nakagawa, “Development of amphiphilic ?-PGA-nanoparticulate cytosolic protein delivery carrier”, Biochem. Biophys. Res. Commun., 366, 408-413 (2008).

Tran Hang Thi, Michiya Matsusaki, Dongjian Shi, Tatsuo Kaneko, Mitsuru Akashi, “Synthesis and Properties of Coumaric Acid Derivative Homopolymers”, J. Biomater. Sci. Polymer Edn., 19, 75-85 (2008).

Michiya Matsusaki, Masaaki Omichi, Ikuro Maruyama, Mitsuru Akashi, “Physical Adsorption of Human Thrombomodulin (ART-123) onto Polymeric Biomaterials for Developing An Antithrombogenic Blood-Contacting Material”, J. Biomed. Mater. Res. Part:A, 84A, 1-9 (2008).

Yusuke Ikumi, Toshiyuki Kida, Shinji Sakuma, Shinji Yamashita, Mitsuru Akashi, “Polymer-Phloridzin Conjugates as an Anti-diabetic Drug that Inhibits Glucose Absorption through the Na+/Glucose Cotransporter (SGLT1) in the Small Intestine”, J. Controlled Release, 125, 42-49 (2008).

Xin Wang, Tomofumi Uto, Takami Akagi, Mitsuru Akashi, Masanori Baba, “Poly(γ-glutamic Acid) nanoparticles as an efficient antigen delivery and adjuvant system: potential for an anti-AIDS vaccine”, J. Med. Virol., 80, 11-19 (2008).