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免疫制御学(中外製薬)
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兼任・客員教官
兼任教官リスト
客員教官リスト

  研究室メンバー

益谷 央豪 准教授
金尾 梨絵 大学院生(D3)
小野 香苗 大学院生(M2)
片岡 裕貴

大学院生(M2)


研究業績

■原著論文など

  1. Akagi, J., Masutani, C., Kataoka, Y., Kan, T., Ohashi, E., Mori, T., Iwai, S., Ohmori, H., and Hanaoka, F. Interaction with DNA polymerase ? is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. DNA Repair (Amst), 2009. in press
  2. Kimura, T., Takeuchi, T., Kumamoto-Yonezawa, Y., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka, F., Sugawara, F., Yoshida, H., and Mizushina, Y. Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Bioorganic Medicinal Chemistry, 17, 1811-1816, 2009.
  3. Masutani, C., Hanaoka, F., Ahmad, S.I. Xeroderma Pigmentosum Variant, XP-V: its product and biological roles. Adv. Exp. Med. Biol., 637, 93-102, 2008.
  4. Ohkumo, T., Masutani, C. Eki, T., Hanaoka, F. Use of RNAi in C. elegans. Methods Mol. Biol., 442, 129-137, 2008.
  5. Yasui, M., Suenaga, E., Koyama, N., Masutani, C., Hanaoka, F., Gruz, P., Shibutani, S., Nohmi, T., Hayashi, M., and Honma, M. Miscoding property of 2’-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases. J. Mol. Biol., 377, 1015-1023, 2008.
  6. Hidaka, K., Yamada, M., Kamiya, H., Masutani, C., Harashima, H., Hanaoka, F., and Nohmi, T. Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase ?. DNA Repair (Amst), 7, 497-506, 2008.
  7. Shiomi, Y., Masutani, C., Hanaoka, F., Kimura, H., and Tsurimoto, T. A second PCNA loader complex, Ctf18-RFC, specifically stimulates DNA polymerase ??activity. J. Biol. Chem., 282, 20906-20914, 2007.
  8. Satou, K., Kasai, H., Masutani, C., Hanaoka, F., Harashima, H., and Kamiya, H. 2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract. Biochemistry, 46, 6639-6646, 2007.
  9. Masuda, K., Ouchida, R., Hikida, M., Kurosaki, T., Yokoi, M., Masutani, C., Seki, M., Wood, R.D., Hanaoka, F., and O-Wang, J. DNA polymerase ? and ? function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J. Biol. Chem., 282, 17387-17394, 2007.
  10. Shimizu, M., Gruz, P., Kamiya, H., Masutani, C., Xu, Y., Sugiyama, H., Harashima, H., Hanaoka, F., and Nohmi, T. Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase ?. Biochemistry, 46, 5515-5522, 2007
  11. Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., Masutani, C., and Hanaoka, F. Ultraviolet B radiation induces epithelial tumors in mice lacking Pol? and mesenchymal tumors in mice deficient for Pol?. Mol. Cell. Biol., 26, 7696-7706, 2006.
  12. Yuasa S., M., Masutani, C., Hirano, A., Cohn, M.A., Yamaizumi, M., Nakatani, Y., and Hanaoka, F. A human DNA polymerase ? complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Genes Cells, 11, 731-744, 2006.
  13. Ohkumo, T., Masutani, C., Eki, T., and Hanaoka, F. Deficiency of the Caenorhabditis elegans DNA polymerase ? homologue increases sensitivity to UV radiation during germ-line development. Cell Struct. Funct., 31, 29-37, 2006.
  14. Kawamoto, T., Araki, K., Sonoda, E., Yamashita, Y.M., Harada, K.K., Kikuchi, K., Masutani, C., Hanaoka, F., Nozaki, K., Hashimoto, N., and Takeda, S. Dual roles for DNA polymerase ? in homologous DNA recombination and translesion DNA synthesis. Mol. Cell, 20, 793-799, 2005.
  15. Chiapperino, D., Cai, M., Sayer, J.M., Yagi, H., Kroth, H., Masutani, C., Hanaoka, F., Jerina, D.M., and Cheh, A.M. Error-prone translesion synthesis by human DNA polymerase ? on DNA containing deoxyadenosine adducts of 7.8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. J. Biol. Chem., 280, 39684-39692, 2005.
  16. Nishi, R., Okuda, Y., Watanabe, E., Mori, T., Iwai, S., Masutani, C., Sugasawa, K., and Hanaoka, F. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Mol. Cell. Biol., 25, 5664-5674, 2005.
  17. Martomo, S.A., Yang, W.W., Wersto, R.P., Ohkumo, T., Kondo, Y., Yokoi, M., Masutani, C., Hanaoka, F., and Gearhart, P.J. Different mutationsignatures in DNA polymerase ?- and MSH6-deficient mice suggest separate roles in antibody diversification. Proc. Natl. Acad. Sci. USA, 102, 8656-8661, 2005.
  18. Kusumoto, R., Masutani, C., Simmyo, S., Iwai, S., and Hanaoka, F. DNA binding properties of human DNA polymerase ?: Implication for polymerase switching. Genes Cells, 9, 1139-1150, 2004.
  19. Seki, M., Masutani, C., Yang, L.W., Schuffert, A., Iwai, S., Bahar, I., and Wood, R.D. High-efficiency bypass of DNA damage by human DNA polymerase Q. EMBO J., 23, 4484-4494, 2004.
  20. Ohashi, E., Murakumo, Y., Kanjo, N., Akagi, J., Masutani, C., Hanaoka, F., and Ohmori, H. Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells, 9, 523-531, 2004
  21. Suzuki, N., Itoh, S., Poon, K., Masutani, C., Hanaoka, F., Ohmori, H., Yoshizawa, I., and Shibutani, S. Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases ? and ?. Biochemistry, 43, 6304-6311, 2004
  22. Takasawa, K., Masutani, C., Hanaoka, F., and Iwai, S. Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. Nucl. Acids Res., 32, 1738-1745, 2004. .
  23. Niimi, A., Limsirichaikul, S., Yoshida, S., Iwai, S., Masutani, C., Hanaoka, F., Kool, E. T., Nishiyama, Y., and Suzuki, M. Palm mutants in DNA polymerases ? and ? alter DNA replication fidelity and translesion activity. Mol. Cell. Biol., 24, 2734-2746, 2004.
  24. McCulloch, S.D., Kokoska R.J., Masutani, C., Iwai, S., Hanaoka, F., and Kunkel, T.A. Preferential cis-syn thymine dimer bypass by DNA polymerase ? occurs with biased fidelity. Nature, 428, 97-100, 2004.
  25. Bassett, E., Vaisman, A., Havener, J. M., Masutani, C., Hanaoka, F., and Chaney, S.G. Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases ? and ? in vitro. Biochemistry, 42, 14197-14206, 2003.
  26. Higurashi, M., Ohtsuki, T., Inase, A., Kusumoto, R., Masutani, C., Hanaoka, F., and Iwai, S. Identification and characterization of an intermediate in the alkali degradation of (6-4) photoproduct-containing DNA. J. Biol. Chem., 278, 51968-51973, 2003.
  27. Jaloszynski, P., Masutani, C., Hanaoka, F., Perwz, A.B., and Nishimura, S. 8-Hydroxyguanine in a mutational hotspot of c-Ha-ras gene causes misreplication, “action-at-a-distance” mutagenesis and inhibition of replication. Nucleic Acids Res., 31, 6085-6095, 2003.
  28. McDonald, J.P., Frank, E.G., Plosky, B.S., Rogozin, I.B., Masutani, C., Hanaoka, F., Woodgate, R., and Gearhart, P.J. 129-derived strains of mice are deficient in DNA polymerase ? and have normal immunoglobulin hypermutation. J. Exp. Med., 198, 635-643, 2003.
  29. Shimizu, M., Gruz, P., Kamiya, H., Kim, S.-R., Pisani, F.M., Masutani, C., Kanke, Y., Harashima, H., Hanaoka, F., and Nohmi, T. Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Reports, 4, 269-273, 2003.
  30. Bassett, E., Vaisman, A., Tropea, K.A., McCall, C.M., Masutani, C., Hanaoka, F., and Chaney, S.G. Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerase ? and ?. DNA Repair (Amst), 1, 1003-1016, 2002.
  31. Yamada, A., Masutani, C., and Hanaoka, F. Detection of reduced RNA synthesis in UV-irradiated Cockayne syndrome group B cells using an isolated nuclear system. Biochim. Biophys. Acta, 1592, 129-134, 2002.
  32. Uchida, A., Sugasawa, K., Masutani, C., Dohmae, N., Araki, M., Yokoi, M., Ohkuma, Y., and Hanaoka, F. The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH. DNA Repair (Amst), 1, 449-461, 2002.
  33. Kusumoto, R., Masutani, C., Iwai, S., and Hanaoka, F. Translesion synthesis by human DNA polymerase ? across thymine glycol lesions. Biochemistry, 41, 6090-6099, 2002.
  34. Chiapperino, D., Kroth, H., Kramarczuk, I. H., Sayer, J.M., Masutani, C., Hanaoka, F., Jerina, D.M., and Cheh, A.M. Preferential misincorporation of purine nucleotides by human DNA polymerase ? opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts. J. Biol. Chem., 277, 11765-11771, 2002.
  35. Broughton, B.C., Cordonnier, A., Kleijer, W.J., Jaspers, N.G.J., Fawcett, H., Raams, A., Garritsen, V.H., Stary, A., Avril, M.-F., Boudsocq, F., Masutani, C., Hanaoka, F., Fuchs, R.P., Sarasn, A., and Lehmann, A.R. Molecular analysis of mutations in DNA polymerase ? in xeroderma pigmentosum-variant patients. Proc. Natl. Acad. Sci. USA, 99, 815-820, 2002.
  36. Kuraoka, I., Robins, P., Masutani, C., Hanaoka, F., Gasparutto, D., Cadet, J., Wood, R.D., and Lindahl, T. Oxygen free-radical damage to DNA: translesion synthesis by human DNA polymerase ? and resistance to exonuclease action at cyclopurine deoxynucleoside residues. J. Biol. Chem., 276, 49283-49288, 2001.
  37. Matsuda, T., Bebenek, K., Masutani, C., Rogozin, I.B., Hanaoka, F., and Kunkel, T.A. Error rate and specificity of human and murin DNA polymerase ?. J. Mol. Biol., 312, 335-346, 2001.
  38. Levine, R.L., Miller, H., Grollman, A., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka, F., and Moriya, M. Translesion DNA synthesis catalyzed by human pol ? and pol ? across 1,N6-ethenodeoxyadenosine. J. Biol. Chem., 276, 18717-18721, 2001.
  39. Araki, M., Masutani, C., Takemura, M., Uchida, A., Sugasawa, K., Kondo, J., Ohkuma, Y., and Hanaoka, F. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J. Biol. Chem., 276, 18665-18672, 2001.
  40. Ishikawa, T., Uematsu, N., Mizukoshi, T., Iwai, S., Iwasaki, H., Masutani, C., Hanaoka, F., Ueda, R., Ohmori, H., and Todo, T. Mutagenic and non-mutagenic bypass of DNA lesions by Drosophila DNA polymerases dpol? and dpol?. J. Biol. Chem., 276, 15155-15163, 2001.
  41. Ura, K., Araki, M., Saeki, H., Masutani, C., Ito, T., Iwai, S., Mizukoshi, T., Kaneda, Y., and Hanaoka, F. ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes. EMBO J., 20, 2004-2014, 2001.
  42. Kusumoto, R., Masutani, C., Sugasawa, K., Iwai, S., Araki, M., Uchida, A., Mizukoshi, T., and Hanaoka, F. Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro. Mutation Res., 485, 219-227, 2001.
  43. Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., and Hanaoka, F. A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes Dev., 15, 507-521, 2001.
  44. Bebenek, K., Matsuda, T., Masutani, C., Hanaoka, F., and Kunkel, T.A. Proofreading of DNA polymerase ?-dependent replication errors. J. Biol. Chem., 276, 2317-2320, 2001.
  45. Masutani, C., Kusumoto, R., Yamada, A., Yuasa, M., Araki, M., Nogimori, T., Yokoi, M., Eki, T., Iwai, S., and Hanaoka, F. Xeroderma pigmentosum variant: From a human genetic disorder to a novel DNA polymerase. Cold Spring Harbor Symp. Quantit. Biol., LXV, 71-80, 2000.
  46. Yuasa, M., Masutani, C., Eki, T., and Hanaoka, F. Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene. Oncogene, 19, 4721-4728, 2000.
  47. Miao, F., Bouziane, M., Dammann, R., Masutani, C., Hanaoka, F., Pfeifer, G., and O’Connor, T.R. 3-methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins. J. Biol. Chem., 275, 28433-28438, 2000.
  48. Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., and Ohmori, H. Error-prone bypass of certain DNA lesions by the human DNA polymerase ?. Genes Dev., 14, 1589-1594, 2000.
  49. Yamada, A., Masutani, C., Iwai, S., and Hanaoka, F. Complementation of defective translesion synthesis and ultraviolet light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase ?. Nucleic Acids Res., 28, 2473-2480, 2000.
  50. Masutani, C., Kusumoto, R., Iwai, S., and Hanaoka, F. Mechanisms of accurate translesion synthesis by human DNA polymerase ?. EMBO J., 19, 3100-3109, 2000.
  51. Watanabe, Y., Fujimoto, H., Watanabe, T., Maekawa, T., Masutani, C., Hanaoka, F., and Ohkuma, Y. Modulation of TFIIH-associated kinase activity by complex formation and its relationship with CTD phosphorylation of RNA polymerase II. Genes Cells, 5, 407-423, 2000.
  52. Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., and Kunkel, T.A. Low fidelity DNA synthesis by human DNA polymerase ?. Nature, 404, 1011-1013, 2000.
  53. Vaisman, A., Masutani, C., Hanaoka, F., and Chaney, S.G. Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase ?. Biochemistry, 39, 4575-4580, 2000.
  54. Yokoi, M., Masutani, C., Maekawa, T., Sugasawa, K., Ohkuma, Y., and Hanaoka, F. The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of TFIIH to damaged DNA. J. Biol. Chem., 275, 9870-9875, 2000.
  55. Araki, M., Masutani, C., Maekawa, T., Watanabe, Y., Yamada, A., Kusumoto, R., Sakai, D., Sugasawa, K., Ohkuma, Y., and Hanaoka, F. Reconstitution of damage DNA excision reaction from SV40 minichromosomes with purified nucleotide excision repair proteins. Mutation Res., 459, 147-160, 2000.
  56. Hiyama, H., Yokoi, M., Masutani, C., Sugasawa, K., Maekawa, T., Tanaka, K., Hoeijmakers, J.H.J., and Hanaoka, F. Interaction of hHR23 with S5a: The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26S proteasome. J. Biol. Chem., 274, 28019-28025, 1999.
  57. Fujiwara, Y., Masutani, C., Mizukoshi, T., Kondo, J., Hanaoka, F., and Iwai, S. Characterization of DNA recognition by the human UV-damaged-DNA binding protein. J. Biol. Chem., 274, 20027-20033, 1999.
  58. Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., and Hanaoka, F. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase ?. Nature, 399, 700-704, 1999.
  59. JMasutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., and Hanaoka, F. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J., 18, 3491-3501, 1999.
  60. Iwai, S., Mizukoshi, T., Fujiwara, Y., Masutani, C., Hanaoka, F., and Hayakawa, Y. Benzimidazolium triflate-activated synthesis of (6-4) photoproduct-containing oligonucleotides and its application. Nucleic Acids Res., 27, 2299-2303, 1999.
  61. Sugasawa, K., Ng, J.M.Y., Masutani, C., Iwai, S., van der Spek, P.J., Eker, A.P.M., Hanaoka, F., Bootsma, D., and Hoeijmakers, J.H.J. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol. Cell, 2, 223-232, 1998.
  62. Kai, M., Todo, T., Wada, M., Ryo, H., Masutani, C., Kobayashi, H., Morioka, H., Ohtsuka, E., Hanaoka, F., and Sakaguchi, K. A new Drosophila ultraviolet light-damaged DNA recognition endonuclease that selectively nicks a (6-4) photoproduct site. Biochim. Biophys. Acta, 1397, 180-188, 1998.
  63. You, Z., Ishimi, Y., Masai, H., and Hanaoka, F. (2002) Roles of Mcm7 and Mcm4 subunits in DNA helicase activity of mouse Mcm4/6/7 complex. J. Biol. Chem. 277, 42471-42479.
  64. Sugasawa, K., Ng, J.M.Y., Masutani, C., Maekawa, T., Uchida, A., van der Spek, P.J., Eker, A., Rademakers, S., Visser, C., Aboussekhra, A., Wood, R.D., Hanaoka, F., Bootsma, D., and Hoeijmakers, J.H.J. Two human homologues of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol. Cell. Biol., 17, 6924-6931, 1997.
  65. Masutani, C., Araki, M., Sugasawa, K., van der Spek, P.J., Yamada, A., Uchida, A., Maekawa, T., Bootsma, D., Hoeijmakers, J.H.J., and Hanaoka, F. Identification and characterization of XPC-binding domain of hHR23B. Mol. Cell. Biol., 17, 6915-6923, 1997.
  66. Saijo, M., Kuraoka, I., Masutani, C., Hanaoka, F., and Tanaka, K. Sequential binding of DNA repair proteins RPA and ERCC1 to XPA in vitro. Nucleic Acids Res., 24, 4719-4724, 1996.
  67. Ito, K., Asano, M., Hughes, P., Kohzaki, H., Masutani, C., Hanaoka, F., Kerppola, T., Curran, T., Murakami, Y., and Ito, Y. c-jun stimulates origin-dependent DNA unwinding by polyomavirus large T antigen. EMBO J., 15, 5636-5646, 1996.
  68. Sugasawa, K., Masutani, C., Uchida, A., Maekawa, T., van der Spek, P.J., Bootsma, D., Hoeijmakers, J.H.J., and Hanaoka, F. HHR23B, a human RAD23 homologue, stimulates XPC protein in nucleotide excision repair in vitro. Mol. Cell. Biol., 16, 4852-4861, 1996.
  69. van der Spek, P.J., Eker, A., Rademakers, S., Visser, C., Sugasawa, K., Masutani, C., Hanaoka, F., Bootsma, D., and Hoeijmakers, J.H.J. XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes. Nucleic Acids Res., 24, 2551-2559, 1996.
  70. Matsumoto, K., Seki, M., Masutani, C., Tada, S., Enomoto, T., and Ishimi, Y. Stimulation of DNA synthesis by mouse DNA helicase B in a DNA replication system containing eukaryotic replication origins. Biochemistry, 34, 7913-7922, 1995.
  71. Kamiya, H., Miura, H., M-Kamiya, N., Ishikawa, H., Sakaguchi, T., Inoue, H., Sasaki, T., Masutani, C., Hanaoka, F., Nishimura, S., and Ohtsuka, E. 8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells. Nucleic Acids Res., 23, 2893-2899, 1995.
  72. Matsuda, T., Saijo, M., Kuraoka, I., Kobayashi, T., Nakatsu, Y., Nagai, A., Enjoji, T., Masutani, C., Sugasawa, K., Hanaoka, F., Yasui, A., and Tanaka, K. DNA repair protein XPA binds replication protein A (RPA). J. Biol. Chem., 270, 4152-4157, 1995.
  73. Kamiya, H., M-Kamiya, N., Fujimuro, M., Kido, K., Inoue, H., Nishimura, S., Masutani, C., Hanaoka, F., and Ohtsuka, E. Comparison of incorporation and extension of nucleotides in vitro opposite 8-hydroxyguanine (7,8 dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene. Jpn. J. Cancer Res., 86, 270-276, 1995.
  74. van der Spek, P.J., Smit, E.M.E., Beverloo, H.B., Sugasawa, K., Masutani, C., Hanaoka, F., Hoeijmakers, J.H.J., and Hagemeijer, A. Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. Genomics, 23, 651-658, 1994.
  75. Kamiya, H., Murata, N., Murata, T., Iwai, S., Matsukage, A., Masutani, C., Hanaoka, F., and Ohtsuka, E. Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation. Nucleic Acids Res., 21, 2355-2361, 1993.
  76. Wada, M., Miyazawa, H., Wang, R.-S.,Mizuno, T., Sato, A., Asashima, M., and Hanaoka, F. (2002) The second subunit of mouse DNA polymerase e, DPE2, interacts with SAP18 and recruits the Sin3 Co-repressor protein to DNA. J. Biochem. (Tokyo) 131, 307-311.
  77. Masutani, C., Sugasawa, K., Asahina, H., Tanaka, K., and Hanaoka, F. Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts: II. Defective DNA repair synthesis by xeroderma pigmentosum cell extracts. J. Biol. Chem., 268, 9105-9109, 1993.
  78. Sugasawa, K., Masutani, C., and Hanaoka, F. Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts: I. Development of a cell-free system detecting excision repair of UV-irradiated SV40 chromosomes in human cell extracts. J. Biol. Chem., 268, 9098-9104, 1993.
  79. Kamiya, H., Sakaguchi, T., Murata, N., Fujimuro, M., Miura, H., Ishikawa, H., Shimizu, M., Inoue, H., Nishimura, S., Matsukage, A., Masutani, C., Hanaoka, F., and Ohtsuka, E. In vitro replication study of modified bases in ras sequences. Chem. Pharm. Bull., 40, 2792-2795, 1992.
  80. Kamiya, H., Suzuki, M., Komatsu, Y., Miura, H., Kikuchi, K., Sakaguchi, T., Murata, N., Masutani, C., Hanaoka, F., and Ohtsuka, E. An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions. Nucleic Acids Res., 20, 4409-4415, 1992.
  81. Eki, T., Enomoto, T., Masutani, C., Miyajima, A., Takada, R., Murakami, Y., Ohno, T., Hanaoka, F., and Ui, M. Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication. J. Virol., 65, 4874-4881, 1991.
  82. Masutani, C., Enomoto, T., Suzuki, M., Hanaoka, F., and Ui, M. DNA primase stimulatory factor from mouse FM3A cells has an RNase H activity. J. Biol. Chem., 265, 10210-10216, 1990.
  83. Suzuki, M., Enomoto, T., Masutani, C., Hanaoka, F., Yamada, M., and Ui, M. DNA primase-DNA polymerase ? assembly from mouse FM3A cells: purification of constituting enzymes, reconstitution, and analysis of RNA priming as coupled to DNA synthesis. J. Biol. Chem., 264, 10065-10071, 1989.
 

■日本語総説など+

  1. 益谷央豪 動物細胞の紫外線DNA損傷の修復と複製 蛋白質核酸酵素(共立出版)増刊『染色体サイクル』54 (4), 399-405, 2009.
  2. 大雲剛志、益谷央豪、花岡文雄 真核生物が獲得した天然の日焼け止めクリーム―XP-V群色素性乾皮症遺伝子産物;DNAポリメラーゼ?(イータ)について- 放射線生物研究 37 (1), 1-11, 2002.
  3. 花岡文雄、益谷央豪 DNAポリメラーゼ?:DNA修復欠損遺伝病の研究から損傷乗り越え型DNAポリメラーゼの発見へ 生化学 74 (3), 213-217, 2002.
  4. 益谷央豪、花岡文雄 色素性乾皮症バリアントにおける損傷乗り越えDNA複製の異常 蛋白質核酸酵素(共立出版)増刊『DNA修復ネットワークとその破綻の分子病態』 46 (8), 1097-1106, 2001.
  5. 益谷央豪、花岡文雄 バリアント型色素性乾皮症と損傷乗り越えDNA複製 医学のあゆみ(医歯薬出版)194(9), 679-680, 2000.
  6. 楠本理加、益谷央豪、花岡文雄 V群色素性乾皮症遺伝子産物 DNAポリメラーゼ?(イータ)について ファルマシア 36 (4), 274-278, 2000.
  7. 山田亜夕美、益谷央豪、花岡文雄 損傷を乗り越える新規DNAポリメラーゼ 生化学 72 (3), 45-48, 2000.
  8. 湯浅真弓、益谷央豪、花岡文雄 色素性乾皮症バリアント群の原因遺伝子のクローニング 遺伝子医学(メディカルドゥ)14 (1), 134-138, 2000.
  9. 益谷央豪、花岡文雄 色素性乾皮症研究の最前線-DNA修復欠損と損傷DNA複製欠損実験医学(羊土社)17 (19), 2584-2589, 1999.
  10. 益谷央豪、花岡文雄 色素性乾皮症バリアント(XPV)遺伝子はDNAポリメラーゼ?をコードする 実験医学(羊土社)17 (13), 1648-1651, 1999.
  11. 荒木真理人、益谷央豪、花岡文雄 ヌクレオチド除去修復の分子機構 蛋白質核酸酵素(共立出版)44 (12), 1845-4851, 1999.
  12. 益谷央豪、花岡文雄 真核細胞のヌクレオチド除去修復 実験医学(羊土社)16 (8), 1076-1081, 1998.
  13. 横井雅幸、益谷央豪、花岡文雄 DNA修復と細胞周期制御 蛋白質核酸酵素(共立出版)41 (12), 1791-1798, 1996.
  14. 益谷央豪、花岡文雄 染色体複製の機構 細胞増殖の制御(豊島久真男編集)南江堂(東京)第2刷 186-199, 1995.
  15. 益谷央豪、菅澤薫、花岡文雄 真核細胞のヌクレオチド除去修復 細胞工学(秀潤社)13 (8), 690-700, 1994.
  16. 菅澤薫、益谷央豪、花岡文雄 無細胞系を用いたクロマチンDNAの複製と修復 実験医学(羊土社)11(20), 2716-2721, 1993 .
 
 
 

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