おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

Genetic evolution of cerebral cortex size determinants
Dr. Víctor Borrell (Institute of Neuroscience, CSIC-UMH, San Juan de Alicante, Spain)

Date/Time

July 30, 2018 (Mon), 16:00-17:30

Place

3F Seminar Room, Nanobiology Building

Speaker

Dr. Víctor Borrell (Institute of Neuroscience, CSIC-UMH, San Juan de Alicante, Spain)

Title

Genetic evolution of cerebral cortex size determinants

Abstract

Cerebral cortex size differs dramatically between reptiles, birds and mammals owing to developmental differences in neuron production. In mammals, signaling pathways regulating neurogenesis have been identified, but genetic differences behind their evolution across amniotes remain unknown. I will present recent data from our laboratory showing that direct neurogenesis from Radial Glia Cells, with limited neuron production, dominates the avian, reptilian and mammalian paleocortex, whereas in the evolutionarily recent mammalian neocortex most neurogenesis is indirect via basal progenitors. Our experiments of gain- and loss-of-function in mouse, chick and snake embryos, and human cerebral organoids, demonstrate that high Slit/Robo - low Dll1 signaling, via Jag1/2, is necessary and sufficient to drive direct neurogenesis. Attenuating Robo signaling and enhancing Dll1 in snakes and birds recapitulates the formation of basal progenitors and promotes indirect neurogenesis. Our study identifies modulation in activity levels of conserved signaling pathways as a primary mechanism driving the expansion and increased complexity of the mammalian neocortex during amniote evolution.

Host

Nobuhiko Yamamoto
Tel: 06-6879-4636
E-mail: nobuhiko@fbs.osaka-u.ac.jp


http://www.fbs.osaka-u.ac.jp/jpn/seminar/seminar/docs/fbs-seminar-yamamoto-20180730.pdf