おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

Molecular mechanism of circuit formation in the rodent somatosensory barrel cortex
Tomomi Shimogori (RIKEN)

日時

June 26, 2012 (Tue), 16:00-17:00

場所

3F Seminar Room, Nanobiology Building

演者

Tomomi Shimogori (RIKEN)

演題

Molecular mechanism of circuit formation in the rodent somatosensory barrel cortex

要旨

Dynamic morphological changes of dendrites and synapse formation are one of the most remarkable features of the developing brain, and make it possible for neurons to change their connectivity depending on stimuli from the outside world and to adapt behavior. To elucidate the molecular mechanism of activity dependent circuit formation, we used rodent somatosensory barrel cortex, which development occurs in their first postnatal week. In the barrel cortex, thalamocortical axons (TCAs) from individual thalamic barrelloids are almost entirely confined to single barrel clusters, followed by arrangement of cortical layer IV neurons into barrel hollows and septa. Addition to this, unidirectional dendrite formation of barrel neurons toward barrel hollows occurs for efficient synapse formation with TCAs. Using Allen's brain atlas and our own microarray study, we isolated candidate molecules, which mediate activity dependent barrel formation. Moreover, gain and loss of function demonstrated that when and how these molecules are involved in barrel development. Our results provide the molecular framework of barrel cortex development, which is controlled by neuronal activity via thalamocortical axon.

世話人

Nobuhiko Yamamoto
Tel: 06-6879-4636
E-mail: nobuhiko[at]fbs.osaka-u.ac.jp