おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

Sensory development of the inner ear
Takahiro Ohyama (House Ear Institute)

日時

November 18, 2010 (Thu), 15:00-16:00

場所

2F Seminar Room, Annex Building

演者

Takahiro Ohyama (House Ear Institute)

演題

Sensory development of the inner ear

要旨

The mammalian inner ear detects sound with the organ of Corti, an intricately patterned region of the cochlea in which one row of inner hair cells and three rows of outer hair cells are surrounded by specialized supporting cells. The organ of Corti derives from a prosensory domain that runs the length of the cochlear duct and is bounded by two nonsensory domains, Kölliker's organ on the neural side and the outer sulcus on the abneural side. Although much progress has been made in identifying the signals regulating organ of Corti induction and differentiation, less is known about the mechanisms that establish sensory and nonsensory territories in the cochlear duct. We show that a gradient of bone morphogenetic protein (BMP) signaling is established in the abneural-neural axis of the cochlea. Analysis of compound mutants of Alk3/6 type I BMP receptors shows that BMP signaling is necessary for specification of the prosensory domain destined to form the organ of Corti. Reduction of BMP signaling in Alk3/6 compound mutants eliminates both the future outer sulcus and the prosensory domain, with all cells expressing markers of Kölliker's organ. Interestingly, ear-specific disruption of the Alk3/6 type I BMP receptor leads to a loss of the future outer sulcus, a mirror-image duplication of the organ of Corti and Kölliker's organ and massive over-production of hair cells with reversed polarity. Our results suggest BMP signaling is required for patterning sensory and nonsensory tissue in the mammalian cochlea.

世話人

Shigeru Kondo
Tel: 06-6879-7997


...


http://www.fbs.osaka-u.ac.jp/jpn/seminar/seminar/docs/fbs-seminar-skondo-20101118.pdf