おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

「The Life of breath: Epithelial stem cells of the adult lung」
Duke University, U.S.A. (Brigid Hogan, Ph.D., FRS)

Hogan先生は、マウス分子遺伝学研究の先駆者のひとりであり、長年にわたり初期胚発生および肺の発生の研究を行われてきました。今回のセミナーでは、最近行われている肺の幹細胞の研究についてお話しいただける予定です。

Date/Time

Oct 12, 2017 (Thu), 17:00-18:00

Place

2F Seminar room, BioSystems Building

Speaker

Brigid Hogan, Ph.D., FRS (Duke University, U.S.A.)

Title

The Life of breath: Epithelial stem cells of the adult lung

Abstract

Lung diseases, such as asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD), emphysema, and idiopathic pulmonary fibrosis, and damage caused by environmental factors and virus infections, affect the health of many millions of people worldwide. Consequently, considerable effort is being made to identify the different epithelial stem cells of the adult lung, the niches in which they reside, and the mechanisms by which they function to maintain the organ over the long term and to repair it after damage. Our lab has contributed by using a variety of approaches, including the in vitro 3D organoid culture of primary human and mouse lung stem/progenitor cells, and in vivo models of mouse lung injury and repair. Our studies have revealed a remarkable capacity of differentiated epithelial cells to reenter the cell cycle and/or change their fate in response to the need for repair. After a general review the talk will focus on the Type 2 epithelial stem cells of the distal alveolar region of the lung, their interactions with stromal cells, including Pdgfra+ lipofibroblasts, and the signaling pathways regulating their proliferation and differentiation.

Host

Hiroshi Sasaki


...


http://www.fbs.osaka-u.ac.jp/jpn/seminar/seminar/docs/fbs-seminar-sasaki-20171012.pdf