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English

Maturation of dsDNA Bacteriophage: insights into elegantly programmed nanomachines
Jack Johnson (The Scripps Research Institute)

日時

April 10, 2012 (Tue), 14:00-15:00

場所

1F Seminar room, Nanobiology Building

演者

Jack Johnson (The Scripps Research Institute)

演題

Maturation of dsDNA Bacteriophage: insights into elegantly programmed nanomachines

要旨

The accessibility of bacteriophage maturation to structural, biophysical and genetic methods has enhanced our understanding of novel processes in biological dynamics. These include identifying mechanisms that create energy landscapes for exothermic virus maturation as well as discovering a means of directing the effects of thermal fluctuations for particle development through a Brownian ratchet. The structurally encoded program that directs particle maturation will be described.

参考文献

  1. Tang, J., Lander, G. C., Olia, A., Li, R., Casjens, S., Prevelige, P., Jr., Cingolani, G., Baker, T. S., and Johnson, J. E.
    2011.
    Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22.
    Structure 19:496-502.
  2. Gertsman, I., Gan, L., Guttman, M., Lee, K., Speir, J. A., Duda, R. L., Hendrix, R. W., Komives, E. A., and Johnson, J. E.
    2009.
    An unexpected twist in viral capsid maturation.
    Nature 458:646-651.
  3. Johnson, J. E.
    2010.
    Virus particle maturation: insights into elegantly programmed nanomachines.
    Curr Opin Struct Biol 20:210-6.
  4. Lander, G. C., Baudoux, A. C., Azam, F., Potter, C. S., Carragher, B., and Johnson, J. E.
    2012.
    Capsomer dynamics and stabilization in particles with T=12 quasi-symmetry; the cryoEM reconstructions of the marine bacteriophage SIO-2 and its procapsid.
    Structure accepted for publication.

世話人

Keiichi Namba
Tel: 06-6879-4625
E-mail: keiichi[at]fbs.osaka-u.ac.jp