おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

From hibernation to proliferation: Modulating centromere and kinetochore function across cell state
Iain Cheeseman (MIT)

Date/Time

November 26, 2018 (Mon), 16:30-17:30

Place

2F Seminar Room, BioSystems Building

Speaker

Iain Cheeseman (MIT)

Title

From hibernation to proliferation: Modulating centromere and kinetochore function across cell state

Abstract

The macromolecular kinetochore structure plays an essential role in chromosome segregation by mediating chromosome-microtubule interactions. Prior work has analyzed centromere and kinetochore function primarily in rapidly dividing cell types. However, recent work indicates that the kinetochore is modulated within the same organism, with kinetochore composition and function changing over the cell cycle, during meiosis and development, and across diverse physiological situations. This plasticity appears to be critical for the kinetochore machine to flexibly adapt to diverse situations and functional requirements. I will discuss specific examples of how kinetochore function is modulated under different physiological contexts. In particular, I will discuss our work to understand how centromere and kinetochore function is maintained during extended periods of cell cycle arrest to ensure that cells are able to undergo future proliferation following release from this hibernation.

Host

Tatsuo Fukagawa
Tel: 06-6879-4428
E-mail: tfukagawa@fbs.osaka-u.ac.jp


セミナー終了前、後に、Cheeseman博士と個別のdiscussionを行います。面談希望者は、深川までご連絡ください。


http://www.fbs.osaka-u.ac.jp/jpn/seminar/seminar/images/fbs-seminar-fukagawa-20181026-b.pdf