おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

Transcriptional control in time and space
Nadine L. Vastenhouw (Max Planck Institute of Molecular Cell Biology and Genetics)

Date/Time

June 4, 2018 (Mon), 16:00-17:00

Place

2F Seminar room, BioSystems Building

Speaker

Nadine L. Vastenhouw (Max Planck Institute of Molecular Cell Biology and Genetics)

Title

Transcriptional control in time and space

Abstract

Upon fertilization, the genome of animal embryos is transcriptionally inactive until the controlled onset of transcription during the maternal-to-zygotic transition. We focus on this genome-wide onset of transcription in zebrafish, with the aim to understand how the transcriptional machinery and chromatin template are brought together in time and space to robustly regulate transcription in hundreds of blastomeres during genome activation. We analyze transcriptional regulation quantitatively (quantification of repressors, activators, number of cells at genome activation, transcripts) and at high resolution (imaging transcripts, chromatin architecture, and transcriptional machinery at high resolution) in the context of the embryo. This allows us to address questions about the timing of transcription initiation during development, synchrony between cells, and the function and establishment of nuclear architecture. I will present our latest results.

Host

Tatsuo Fukagawa
Tel: 06-6879-4428
E-mail: tfukagawa@fbs.osaka-u.ac.jp


セミナー終了前、後に、Vastenhouw博士と個別のdiscussion を行います。面談希望者 は、深川までご連絡ください。


http://www.fbs.osaka-u.ac.jp/jpn/seminar/seminar/docs/fbs-seminar-fukagawa-20180604.pdf