おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

When DNA meets the cytoplasm -- does the cytoplasmic DNA sensor cGAS respond to mitotic chromosomes?
Prof. Hironori Funabiki (The Rockefeller University, New York)

7月12日にロックフェラー大学のHiro Funabiki教授のセミナーが生命システム棟2Fのセミナー室で行われます。染色体と細胞質の関連に関する興味深い話が聞けそうです。興味のある方は、ぜひご参加ください。

Date/Time

Jul 12, 2017 (Wed), 16:00-17:00

Place

2F Seminar room, BioSystems Building

Speaker

Prof. Hironori Funabiki (The Rockefeller University, New York)

Title

When DNA meets the cytoplasm -- does the cytoplasmic DNA sensor cGAS respond to mitotic chromosomes?

Abstract

When chromosomes are exposed to the cytoplasm, they induce spindle assembly during mitosis and recruit the nuclear envelope at the exit of mitosis. However, exposure of pathogenic foreign DNAs, such as those from viruses and bacteria, to the cytoplasm is recognized by the cyclic GMP-AMP (cGAMP) synthase cGAS, which induces inflammatory signaling pathways to defend against infections. While the nuclear envelope can prevent cGAS from engaging genomic self-DNA, consequences of exposure of mitotic chromosomes to cGAS upon nuclear envelope breakdown are unknown. Our recent progress toward this question will be presented.

Host

Tatsuo Fukagawa
Tel: 06-6879-4428
E-mail: tfukagawa@fbs.osaka-u.ac.jp


セミナー前に2 時間ほど個別のdiscussion を行います。面談希望者は、深川までご連 絡ください。議論の時間をアレンジいたします。


http://www.fbs.osaka-u.ac.jp/jpn/seminar/seminar/docs/fbs-seminar-fukagawa-20170712.pdf