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English

「New insights into mitotic chromosome assembly and structure」
Prof. William C Earnshaw (Univ Edinburgh, UK)

6/22に下記の要領でエジンバラ大学のEarnshaw教授のセミナー行います。染色体生物学分野で世界の一線で活躍している研究者です。興味のある方は、ご来聴歓迎いたします。

Date/Time

Jun 22, 2017 (Thu), 15:00-16:00

Place

2F Seminar room, BioSystems Building

Speaker

Prof. William C Earnshaw (Univ Edinburgh, UK)

Title

New insights into mitotic chromosome assembly and structure

Abstract

The discovery of mitotic chromosomes by Flemming in 1882 established a major question in Cell Biology that remains unanswered all of these years later: How does the interphase nucleus transform itself into the thread-like mitotic chromosomes that segregate the genome in mitosis? I will discuss some work from our lab and those of our collaborators suggesting that mitotic chromosome formation involves two processes; compaction of the chromatin, and a functionally distinct architectural remodeling that disassembles the structure of the interphase nucleus and causes a helical transformation that results in the formation of individual chromatids. I will also describe recent work from our group that yielded the very surprising finding that in fact, only about 60-70 percent of those chromosomes observed by Flemming was made up of chromatin. A significant fraction - possibly up to 40% - of the volume of mitotic chromosomes is actually comprised of a mysterious highly complex layer that surrounds the chromatin. This chromosome periphery compartment helps to keep chromosomes separate in mitosis and has an important role in efficient reactivation of the nucleoli after mitosis.

Host

Tatsuo Fukagawa
Tel: 06-6879-4428
E-mail: tfukagawa@fbs.osaka-u.ac.jp


セミナー終了前、後に、個別のdiscussionを行います。面談希望者は、深川までご連絡ください。個別面談をアレンジいたします。


http://www.fbs.osaka-u.ac.jp/jpn/seminar/seminar/docs/fbs-seminar-fukagawa-20170622.pdf