おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

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ミトコンドリア動態学研究室〈岡本准教授〉

研究成果

*corresponding author

2020

Original papers
  1. Calvellia H, Krigman J, Onishi M, Narendra DP, Sun N, Okamoto K. (2020).
    Detection of mitophagy in mammalian cells, mice, and yeast.
    Methods in Cell Biology, 155: 557-579.

Reviews, Proceedings and Books
  1. 大西真駿、岡本浩二 (2020).
    マイトファジーの分子機構と生理的意義
    医学のあゆみ., 272: 801-810.
  2. 大西真駿、岡本浩二(2020).
    ミトコンドリア品質管理機構の破綻と遺伝性疾患
    遺伝子医学MOOK.,

2019

Original papers
  1. Morita K, Matsuda F, Okamoto K, Ishii J, Kondo A, Shimizu H.(2019).
    Repression of mitochondrial metabolism for cytosolic pyruvate-derived chemical production in Saccharomyces cerevisiae.
    Microbial Cell Factories, 18: 177.
  2. Zheng L, Shu WJ, Li YM, Mari M, Yan C, Wang D, Yin ZH, Jiang W, Zhou Y, Okamoto K, Reggiori F, Klionsky DJ, Song Z, Du HN.(2019).
    The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.
    Autophagy,19:1-14.
  3. Murakawa T, Okamoto K, Omiya S, Taneike M, Yamaguchi O, Otsu K.(2019).
    A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy.
    Cell Reports, 26: 338-345.e6.
  4. 2018

    Original papers
    1. Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, Dawson TM, Yanagawa T, Okamoto K, Iijima M, *Sesaki H (2018).
      Mitochondrial stasis reveals p62-mediated ubiquitination in Parkin-independent mitophagy.
      Cell Metab., 28(4):588-57.
    2. Liu Y, *Okamoto K(2018).
      The TORC1 signaling pathway regulates respiration-induced mitophagy in yeast.
      Biochem. Biophys Res Commun. , 502: 76-83.
    3. Onishi M, Nagumo S, Iwashita S, *Okamoto K. (2018).
      The ER membrane insertase Get1/2 is required for efficient mitophagy in yeast.
      Biochem. Biophys Res Commun., doi: 10.1016/j.bbrc.2018.05.123
    4. Xu X, *Okamoto K(2018).
      The Nem1-Spo7 protein phosphatase complex is required for efficient mitophagy in yeast.
      Biochem. Biophys Res Commun., 496(1):51-57

    Reviews, Proceedings and Books
    1. Kameoka S, Adachi Y, Okamoto K, Iijima M, *Sesaki H (2018).
      Phosphatidic acid and cardiolipin coordinate mitochondrial dynamics.
      Trends Cell Biol., 28: 67-76.
    2. *岡本浩二(2018).
      分解標識タンパク質が駆動するミトコンドリア特異的オートファジー
      DOJIN NEWS, No. 165, 7-9., ISSN 0385-1516

    2017

    Original papers
    1. Nagumo S, *Okamoto K.(2017).
      Investigation of Yeast Mitophagy with Fluorescence Microscopy and Western Blotting.
      Methods Mol Biol., doi: 10.1007/7651_2017_11
    2. Eiyama A, *Okamoto K (2017).
      Assays for Mitophagy in Yeast.
      Methods Mol Biol., 1567:337-347.

    Reviews, Proceedings and Books
    1. *岡本浩二(2017).
      ミトコンドリア分別・除去システムの基本原理
      The Frontiers in Life Sciencesシリーズ、「オートファジー」, 113-123., ISBN 978-4-525-13481-5

    2015

    Original papers
    1. Sakakibara K, Eiyama A, Suzuki SW, Sakoh-Nakatogawa M, Okumura N, Tani M, Hashimoto A, Nagumo S, Kondo-Okamoto N, Kondo-Kakuta C, Asai E, Kirisako H, Nakatogawa H, Kuge O, Takao T, Ohsumi Y, *Okamoto K (2015).
      Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling
      EMBO J., 34: 2703-2719.
    2. Eiyama A, *Okamoto K (2015).
      Protein N-terminal acetylation by the NatA complex is critical for selective mitochondrial degradation.
      J. Biol. Chem., 290: 25034-25044.

    Reviews, Proceedings and Books
    1. *Okamoto K (2015).
      Preface - The special issue on mitophagy.
      Biochim. Biophys. Acta, 1853: 2755.
    2. Eiyama A, *Okamoto K(2015).
      PINK1/Parkin-mediated mitophagy in mammalian cells.
      Curr. Opin. Cell Biol., 33: 95-101.

    2014

    Original papers
    1. Shiroma S, Jayakody LN, Horie K, Okamoto K, *Kitagaki H (2014).
      Enhancement of ethanol fermentation in Saccharomyces cerevisiae sake yeast by disrupting mitophagy function.
      Appl. Environ. Microbiol., 80: 1002-1012.

    Reviews, Proceedings and Books
    1. Liu L, Sakakibara K, *Chen Q, *Okamoto K (2014).
      Receptor-mediated mitophagy in yeast and mammalian systems.
      Cell Res., 24: 787-795.
    2. *Okamoto K (2014).
      Organellophagy: eliminating cellular building blocks via selective autophagy.
      J. Cell Biol.,205: 435-445.
    3. *Kanki T, Okamoto K (2014).
      Assays for autophagy II: Mitochondrial autophagy.
      Methods Mol. Biol., 1163: 165-173.
    4. *岡本浩二(2014).
      出芽酵母が語る選択的ミトコンドリア分解の基本原理.
      医学のあゆみ・AYUMI「マイトファジー―基礎から疾患との関連まで」, 250: 483-487.

    2013

    Original papers
    1. Eiyama A, Kondo-Okamoto N, *Okamoto K (2013).
      Mitochondrial degradation during starvation is selective and temporally distinct from bulk autophagy in yeast.
      FEBS Lett., 587: 1787-1792.

    Reviews, Proceedings and Books
    1. *Komatsu M, Kuma A, Okamoto K(2013).
      No ATG is an island - the connection of autophagy with diverse pathways and functions.
      EMBO Rep., 14: 219-221.

    2012

    Original papers
    1. Kondo-Okamoto N, Noda NN, Suzuki SW, Nakatogawa H, Takahashi I, Matsunami M, Hashimoto A, Inagaki F, Ohsumi Y, *Okamoto K (2012).
      Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.
      J. Biol. Chem., 287: 10631-10638.

    Reviews, Proceedings and Books
    1. Kondo-Okamoto N, *Okamoto K (2012).
      Mitochondria and autophagy: critical interplay between the two hemostats.
      Biochim. Biophys. Acta, 1820: 595-600.
    2. *岡本浩二 (2012). マイトファジーの分子機構.
      DOJIN BIOSCIENCE SERIES 04,「オートファジー」. ,133-149.
    3. *岡本浩二(2012).
      ミトコンドリア品質管理研究の最前線.
      細胞 THE CELL, 44: 45-48.

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