おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

初期胚発生研究室〈佐々木教授〉

研究成果

Original Papers

2015

Hirate Y, Hirahara S, Inoue K-i, Kiyonari H, Niwa H, *Sasaki H (2015)

Par-aPKC-Dependent and -Independent Mechanisms Cooperatively Control Cell Polarity, Hippo Signaling, and Cell Positioning in 16-Cell Stage Mouse Embryos

Develop. Growth Differ. doi: 10.1111/dgd.12235.

 

Mamada H, Sato T, Ota M, *Sasaki H. (2015)

Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity
of Tead family proteins and Myc

J Cell Sci. 128, 790-803.

 

2014

Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, *Sasaki H (2014)

Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos

Mech. Dev. 132, 44-58. doi: 10.1016/j.mod.2014.01.004.

 

Wicklow E, Blij S, Frum R, Hirate Y, Lang RA, Sasaki H, *Ralston A. (2014)

HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates
in the mouse blastocyst

PLoS Genet. 10, e1004618. doi: 10.1371/journal.pgen.1004618.

 

Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J, *Manzanares M. (2014)

Notch and hippo converge on cdx2 to specify the trophectoderm lineage in the mouse blastocyst.Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos 

Dev Cell. 30, 410-422. doi: 10.1016/j.devcel.2014.06.019.

 

Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, *Nishinakamura R.
(2014)

Redefining the in vivo origin of metanephric nephron progenitors enables generation of
complex kidney structures from pluripotent stem cells.

Cell Stem Cell 14, 53-67. doi: 10.1016/j.stem.2013.11.010.

 

2013

Hirate Y, Hirahara S, Inoue K-i, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T,
Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, *Sasaki H
(2013)

Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.

Curr. Biol. 23, 1181-1194.    Selected for F1000Prime. 

 

Imuta Y, Kiyonari H, Jang CW, Behringer RR, *Sasaki H (2013)

Generation of knock-in mice that express nuclear EGFP and tamoxifen-inducible Cre
recombinase in the notochord from Foxa2 and T loci.

Genesis. 51, 210-218. 

 

2012

Hirate Y, Cockburn K, Rossant J, *Sasaki H (2012)

Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is
regulated in preimplantation embryos.

Proc. Natl. Acad. Sci. USA. 109:E3389-90. doi: 10.1073/pnas.1211810109

 

Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, *Hamada H. (2012)

Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.

Science 338, 226-231.

 

Tao H, Inoue KI, Kiyonari H, Bassuk AG, Axelros JD, Sasaki H, Aizawa S, *Ueno N (2012)

Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.

Dev. Biol.
364, 138-148.

 

2011

Wada K-I, Itoga K, Okano T, Yonemura S, *Sasaki H (2011)

Hippo pathway regulation by cell morphology and stress fibers.

Development 138, 3907-3914.       

 

Sansores-Garcia L, Bossuyt W, Wada KI, Yonemura S, Tao C, Sasaki H, *Halder G. (2011)

Modulating F-actin organization induces organ growth by affecting the Hippo pathway.

EMBO J. 30, 2325-2335.

Mavromatakis YE, Lin W, Metzakopian E, Ferri AL, Yan CH, Sasaki H, Whisett J, *Ang SL (2011).

Foxa1 and Foxa2 positively and negatively regulate Shh signaling to specify ventral midbrain progenitor identity.

Mech Dev. 128, 90-103

 

2010

Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, *Rossant J (2010)

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2

Development 137, 395-403

 

2009

Nishioka N, Inoue K-I, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, *SasakiH. (2009)

The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner
cell mass.

Dev. Cell
16, 398-410.       
   Selected by Faculty of 1000 (must read)

 

Imuta Y, Nishioka N, Kiyonari H, *Sasaki H. (2009)

Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124)

Dev. Dyn. 238, 210-222

 

Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang C-W, Oginuma M, Saga Y, Behringer RR, Kondoh H, *Sasaki H.
(2009)

Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior
extension of the notochord.

Mech. Dev. 126, 791-803.

 

Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, *Ang S-L. (2009)

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.

Dev. Biol. 333, 386-396

 

2008

Ota M, *Sasaki H. (2008)

Mammalian Tead proteins regulate cell proliferation and contact inhibition as a transcriptional mediator of Hippo signaling.

Development. 135, 4059-4069

 

Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, *Sasaki H (2008)

Cthrc1 selectively activates planar cell polarity pathway of Wnt signaling by stabilizing Wnt-receptor complex.

Dev. Cell 15, 23-36.                Selected by Faculty of 1000 (must read)

 

Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, *Sasaki H. (2008)

Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.

Mol. Cell. Biol. 28, 3177-3189.

 

Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, *Sasaki H.(2008)

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.

Mech. Dev. 125, 270-283.        Mech. Dev. Top Cited Article 2008-2010

 

2007

Ferri AL, Lin W, Mavromatikis YE, Wang JC, Sasaki H, Whitsett JA, *Ang SL. (2007)

Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.

Development 134, 2761-2769.

 

Haraguchi R, Motoyama J, Sasaki H, Satoh Y, Miyagawa S, Nakagawa N, Moon A, *Yamada G (2007)

Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.

Development 134, 525-533.

 

2006

Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, *Okano M (2006)

DNA methylation regulates long-range gene silencing of an X-linked homedobox gene cluster in a lineage-specific manner.

Genes. Dev. 20, 3382-3394.

 

2005

Sawada A, Nishizaki Y, Sato H, Yada Y, Nakayama R, Yamamoto S, Nishioka N, Kondoh H, *Sasaki H. (2005)

Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor.

Development. 132, 4719-4729.

 

Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, *Sasaki H (2005)

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex

Development 132, 2535-2546.

 

Takada T, Iida K, Sasaki H, Taira T, *Kimura H (2005)

Expression of ADP-ribosylation factor (ARF)-like protein 6 (ARL6) during mouse embryonic development.

Int. J. Dev. Biol. 49, 891-894.

 

 


Reviews, Proceedings and Books

2016年

竹之下憂祐、加村啓一郎、*佐々木洋2015

マウス胚線維芽細胞NIH3T3を用いた細胞競合モデル系の確立

生体の科学 67, 111-115

2015

Sasaki H. (2015)

Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation
mouse embryos

Semi. Cell Dev. Biol. pii: S1084-9521(15)00100-7. doi: 10.1016/j.semcdb.2015.05.003.

佐藤卓史、*佐々木洋2015

Hippoシグナルによる細胞競合の制御

実験医学 33, 2920-2925.

2014

Hirate Y, *Sasaki H (2014)

The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development.

Tissue Barriers, 2, e28127.

Kondoh H, Kuroiwa A (eds.), New Principles in Developmental Processes, Springer (2014)

Sasaki H "Position-dependent Hippo signaling controls cell fates in preimplantation mouse embryos" pp 249-264.

2013

Oren M., Aylon Y. (eds.), The Hippo Signalin Papthway and Cancer, Springer (2013)

Sasaki H. "Role of Hippo signaling in early mouse development" pp 41-54.

 

2011

佐々木洋、平手良和 (2011)

マウス初期胚発生におけるHippoシグナル経路の役割

細胞工学 30, 935-940

佐々木洋、儘田博志 (2011)

Hippoシグナル経路による細胞間のコミュニケーション

実験医学 29, 1387-1392

 

小幡祐一、城石俊彦、芹川忠夫、田中啓二、米川博通 編

生物機能モデルと新しいリソース・リサーチツール、エル・アイ・シー(2011)

佐々木洋「初期発生―体軸形成」pp55-68

 

2010

Sasaki, H. (2010)

Mechanisms of trophectoderm fate specification in preimplantation mouse development.

Develop. Growth Differ. 52,
263-273.

 

2008

山元進司、佐々木洋 (2008)

Cthrc1Wntと受容体を安定化して平面内細胞極性シグナル経路を選択的に活性化する。

細胞工学 27, 1294-1295

 

 


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