おもろい研究!君ならできる、ここでできる|新しい生物学・生命科学を拓く大学院|大阪大学大学院生命機能研究科

English

免疫細胞生物学研究室〈石井教授〉

研究成果

2014年度

1) Simmons, Ishii M. (2014) Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. Arch. Immunol. Ther. Exp., 62(2); 103-115.

2) Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood N, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S. (2014) Lrig1 controls corneal maintenance through the Stat3-dependent inflammatory pathway. J. Clin. Invest, 124(1):385-97.

3) Cuia G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K. (2014) Characterization of the Interleukin-15 niche in primary and secondary lymphoid organs in vivo. Proc. Natl. Acad. Sci. USA, 111(5):1915-20.

4) David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M, Peyruchaud O. (2014) Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J. Biol. Chem., ePub.

5) Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. (2014) Integrin α9 on lymphatic endothelial cell regulates lymphocyte egress. Proc. Natl. Acad. Sci. USA, 118(8); 3080-3085.

6) Matsumoto S, Fujii S, Sato A, Ibuka S, Kagawa Y, Ishii M, Kikuchi A. (2014) A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J., in press.

7) Rattanapak T, Birchall JC, Young K, Kubo A, Fujimori S, Ishii M, Hook S. (2014) Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS One, 9(2):e89503.

2013年度

1) Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M. (2013) Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques. J. Immunol., 190(2):605-12.

2) Ohta K, Haraguchi N, Kano Y, Kagawa Y, Konno M, Nishikawa S, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Fukami M, Ishii M, Yamamoto H, Doki Y, Mori M, Ishii H. (2013) Depletion of Jarid1b induces cellular senescence in human colorectal cancer. Int. J. Oncol., 42(4):1212-8.

3) Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada G-H, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M. (2013) Dynamic visualization of RANKL and Th17-mediated osteoclast function. J. Clin. Invest., 123(2): 866-873.

4) Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci., 16(5):543-51.

5) Wienert S, Heim D, Kotani M, Lindequist B, Stenzinger A, Ishii M, Hufnagl P, Beil M, Dietel M, Denkert C, Klauschen F (2013) CognitionMaster: An Object-Based Image Analysis Framework. Diagn. Pathol., 8:34.

6) Ishii M, Kikuta J. (2013) Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. Biochim Biophys Acta, 1831(1), 223-227.

7) Kikuta J, Ishii M. (2013) Osteoclast migration, differentiation, and function: novel therapeutic targets for rheumatic diseases. Rheumatology, 52(2):226-34.

8) Ishii M, Fujimori S, Kaneko T, Kikuta J. (2013) Dynamic live imaging of bone: opening a new era with 'bone histodynametry'. J Bone Miner Metab, 31 (5): 507-511.

9) Kikuta J, Kawamura S, Okiji F, Shirazaki M, Sakai S, Saito H, Ishii M (2013) S1P-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc. Natl. Acad. Sci. USA, 110(17): 7009-13.

10) Matsui S, Murota H, Takahashi A, Yang A, Lee J-B, Omiya K, Ohmi M, Kikuta J, Ishii M, Katayama I. (2014) Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation. J. Invest. Dermatol., 134(2): 326-34.

11) Rattanapak T, Birchall J, Young K, Ishii M, Meglinski I, Rades T, Hook S. (2013) Transcutaneous immunization using microneedles and cubosomes:  Mechanistic investigations using optical coherence tomography and two-photon microscopy. J. Control. Release, 172(3):894-903.

12) Kano Y, Konno M, Ohta K, Haraguchi N, Nishikawa S, Kagawa Y, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Ishii M, Mizohata E, Inoue T, Mori M, Doki Y, Ishii H. (2013) Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. Mol Clin Oncol. 1(4):753-757.

13) Kagawa Y, Matsumoto S, Kamioka Y, Mimori M, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M. (2013) Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PLoS One, 8(12): e83629.

14) Nishikawa K, Iwamoto Y, Ishii M. (2013) Development of an in vitro culture method for stepwise differentiation of mouse embryonic stem cells and induced pluripotent stem cells into mature osteoclasts. J. Bone Miner. Metab., ePub.

2012年以前の主な論文

1) Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M*, Mochizuki N* The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122: 1416-1426, 2012.

2) Kikuta J, Iwai K, Saeki Y, Ishii M. S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. Rheumatol. Int. 31: 967-969, 2011.

3) Kowada T, Kikuta, J, Kubo A, Ishii M, Maeda H, Mizukami S, Kikuchi K. In vivo fluorescence imaging of bone-resorbing osteoclasts. J. Am. Chem. Soc., 33(44):17772-17776, 2011.

4) Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J. Exp. Med., 207: 2793-2796, 2010.

5) Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature, 458: 524-528, 2009.

6) Klauschen F, Ishii M, Qi, H., Bajénoff, M., Egen, J.G., Germain, R.N., Meier-Schellersheim, M. Quantifying cellular interaction dynamics in 3-D fluorescence microscopy data. Nature Protoc., 4:1305-1311, 2009.


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