Global COE Study Abroad Project
Aiko Kawasumi（Organismal Biosystems Laboratories / Developmental Genetics Group）
| Date | 2009.9.2-16 |
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| Purpose | To participate in 国際発生生物学会 and poster presentation. Then collaborative research in Cambridge University. |
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Report
<Report1>
(Title) Report of the conference presentation, "16th International Society of Developmental Biologists Congress 2009" and visit to Dr. Yashiro at University of London [No.1]
(Name) Aiko Kawasumi
(Name of laboratory) Developmental Genetics Group (Hamada Lab)
(Destination) 1. Barts and The London, School of Medicine and Dentistry, Queen Mary, University of London, London, UK
2. Edinburgh International Conference Centre, Edinburgh, UK
3. Institut Jacques Monod, Paris, France
(Purpose) To attend 16th International Society of Developmental Biologists Congress 2009 (9/6-10) and hold the meeting with Dr. Yahiro and Dr. Collignon
(Schedule)
2009/09/02 Departure from Osaka Japan and Arrival at London UK
2009/09/03-09/04 University of London
2009/09/05 Departure from London and Arrival at Edinburgh
2009/09/06-10 16th International Society of Dvelopmental Biologists Congress 2009
2009/09/11 Edinburgh University
2009/09/12 Departure from Edinburgh and Arrival at Paris
2009/09/14 Institute Jacob Monod, Departure from Paris and Arrival at London UK
2009/09/15-09/16 Departure from London UK and Arrival at Osaka Japan
(Result)
I attended 16th International Society of Developmental Biologists Congress 2009 in Edinburgh. The congress highlighted the best of world developmental biology, and the location in Edinburgh, Scotland's famous and beautiful capital city. There were over 1,500 participants from 46 different countries making this congress the biggest ever. There were over 130 oral and 900 poster presentations in many fields concerning the developmental biology. Additionally, two major prizes were awarded during the meeting: the Waddington and Beddington medal of the BSDB and the Ross Harrison Prize of the ISDB. The recipients were Liz Robertson and Eddy de Robertis. Including their commemorative speeches, some presentations were not only interesting but also important for me and for our lab, so I asked some presenters many questions. It was very exciting for me that I could gather the latest data and could learn the excellent strategies. Then I presented my progress of my research in a poster session. The title of my poster presentation was "Mechanisms of left-right asymmetric signal generation around the node". When I did presentation, a lot of people came to my poster and asked many questions. Some of them were the lab owners whom I know about only in their papers. I was happy to communicate with the great scientists about my work. To my delight, they provided some advices about my data. They were suggestive for my work.
Finally, I appreciate everyone who helped me, and I also appreciate the financial support by the Global COE Program of our graduate school, which gave me invaluable experiences.
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<Report2>
(Title) Report of the conference presentation, "16th International Society of Developmental Biologists Congress 2009" and visit to Dr. Yashiro at University of London [No.2]
(Name) Aiko Kawasumi
(Name of laboratory) Developmental Genetics Group (Hamada Lab)
(Destination) 1. Barts and The London, School of Medicine and Dentistry, Queen Mary, University of London, London, UK
2. Edinburgh International Conference Centre, Edinburgh, UK
3. Institut Jacques Monod, Paris, France
(Purpose) To attend 16th International Society of Developmental Biologists Congress 2009 (9/6-10) and hold the meeting with Dr. Yahiro and Dr. Collignon
(Schedule)
2009/09/02 Departure from Osaka Japan and Arrival at London UK
2009/09/03-09/04 University of London
2009/09/05 Departure from London and Arrival at Edinburgh
2009/09/06-10 16th International Society of Dvelopmental Biologists Congress 2009
2009/09/11 Edinburgh University
2009/09/12 Departure from Edinburgh and Arrival at Paris
2009/09/14 Institute Jacob Monod, Departure from Paris and Arrival at London UK
2009/09/15-09/16 Departure from London UK and Arrival at Osaka Japan
(Result)
I visited Dr. Kenta Yashiro in University of London. He was my previous colleague of my lab. He introduced his lab members. Everyone was very friendly, so I could be in relaxed manner. Then, we exchanged our latest data and information freely. I explained how the initial asymmetric signal was generated around the node, which is equivalent to Xenopus organizer, after interpretation of the Nodal flow. The detail is in the following. To identify this signal, I investigated the transcriptional regulatory element referred as to ANE. As a result, I explored that the asymmetric signal was the left-side specific Nodal signaling around the node. Then I tried to define the mechanism how Nodal signaling was generated only on the left side of the node in spite of Nodal expression on both sides. From my analysis, Cerl-2 and GDF1 were responsible for the asymmetry of the Nodal signaling around the node. On the other hand, I examined the role of the Nodal signaling in the node by transgenic experiments. The disruption of the Nodal signaling in the node resulted in the Normal Left-Right axis formation. This result indicates that cell autonomous Nodal signaling in the node is dispensable for the normal Left-Right axis formation. After discussion, they showed their equipments in the lab. Next, I visited Dr. Collignon in Institut Jacques Monod, Paris, France. We have known each other since our first meeting in "Frontiers in Developmental Biology" in France last year. We exchanged information mainly about the method of immunostaining of Phosphorylated Smad2.
Finally, I appreciate everyone who helped me, and I also appreciate the financial support by the Global COE Program of our graduate school, which gave me invaluable experiences.
