Laboratory of
Intracellular Membrane Dynamics

The Yoshimori Lab

Graduate School of Frontier Biosciences - Publications

Recent Publications


  • Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes
    Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A
    Nat. Cell Biol. 
    21, 3, 372-383 
    (2019)
    PMID: 30778222
  • Suppression of autophagic activity by Rubicon is a signature of aging
    Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T
    Nat. Commun. 
    10, 1, 847 
    (2019)
    PMID: 30783089
  • Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics
    Chang C, Young LN, Morris KL, von B_low S, Sch_neberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K, Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH
    Mol. Cell 
    73, 2, 339-353 
    (2019)
    PMID: 30581147
  • An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread
    Tan JM, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH
    NAT. MICROBIOL 
    3, 12, 1472_1485 
    (2018)
    PMID: 30478389
  • Induction of selective autophagy in cells replicating hepatitis C virus genome
    Mori H, Fukuhara T, Ono C, Tamura T, Sato A, Fauzyah Y, Wada M, Okamoto T, Noda T, Yoshimori T, Matsuura Y
    J. Gen. Virol. 
    99, 12, 1643-1657 
    (2018)
    PMID: 30311874
  • Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy
    Lee JH, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA
    Autophagy 
    15, 3, 543-557 
    (2018)
    PMID: 30269645
  • Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
    Vukotic, M., Nolte, H., Konig, T., Saita, S., Ananjew, M., Kruger, M., Tatsuta, T., Langer, T.
    Mol. Cell 
    67, 471-483 e477 
    (2017)
    PMID: 28712724
  • Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension.
    Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, Kumasawa K, Yoshimori T, Ikawa M, Saito S
    Am. J. Pathol. 
    188, 11, 2474-2486 
    (2018)
    PMID: 30165042
  • A brain-enriched Drp1 isoform associates with lysosomes, late endosomes and the plasma membrane.
    Itoh K, Adachi Y, Yamada T, Suzuki TL, Otomo T, McBride HM, Yoshimori T, Iijima M, Sesaki H
    J. Biol. Chem. 
    293, 30, 11809-11822 
    (2018)
    PMID: 29853636
  • PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria.
    Saita S, Tatsuta T, Lampe PA, K_nig T, Ohba Y, Langer T
    Embo J. 
    15;37(4) 
    (2018)
    PMID: 29301859
  • Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex.
    Yang F, Yang L, Wataya-Kaneda M, Hasegawa J, Yoshimori T, Tanemura A, Tsuruta D, Katayama I
    J. Dermatol. Sci. 
    89,2,155-164 
    (2018)
    PMID: 29146131
  • Autophagy and Longevity.
    Nakamura S, Yoshimori T
    Mol. Cells 
    41,1, 65-72 
    (2018)
    PMID: 29370695
  • Molecular definitions of autophagy and related processes
    Lorenzo Galluzzi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya, Jos_ Manuel Bravo‐San Pedro, Francesco Cecconi, Augustine M Choi, Charleen T Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Jayanta Debnath, Vojo Deretic, Ivan Dikic, Eeva‐Liisa Eskelinen, Gian Maria Fimia, Simone Fulda, David A Gewirtz, Douglas R Green, Malene Hansen, J Wade Harper, Marja J__ttel_, Terje Johansen,Gabor Juhasz, Alec C Kimmelman,Claudine Kraft, Nicholas T Ktistakis, Sharad Kumar, Beth Levine, Carlos Lopez‐Otin, Frank Madeo, Sascha Martens, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian M_nz, Leon O Murphy, Josef M Penninger, Mauro Piacentini, Fulvio Reggiori, David C Rubinsztein, Kevin M Ryan, Laura Santambrogio, Luca Scorrano, Anna Katharina Simon, Hans‐Uwe Simon, Anne Simonsen, Nektarios Tavernarakis, Sharon A Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue,Qing Zhong, Guido Kroemer
    Embo J. 
    36(13), 1811-1836 
    (2017)
  • Autophagy and kidney inflammation
    Tomonori Kimura, Yoshitaka Isaka, Tamotsu Yoshimori
    Autophagy 
    13(6), 997-1003 
    (2017)
  • Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy
    Yukiko Yoshida, Sayaka Yasuda, Toshiharu Fujita, Maho Hamasaki, Arisa Murakami, Junko Kawawaki, Kazuhiro Iwai, Yasushi Saeki, Tamotsu Yoshimori, Noriyuki Matsuda, Keiji Tanaka
    Proc. Natl. Acad. Sci. U. S. A. 
    114(32):8574-8579 
    (2017)
    PMID: 28743755
  • Small nucleoli are a cellular hallmark of longevity
    Varnesh Tiku, Chirag Jain, Yotam Raz, Shuhei Nakamura, Bree Heestand, Wei Liu, Martin Sp_th, H. Eka. D. Suchiman, Roman-Ulrich M_ller, P. Eline Slagboom, Linda Partridge, Adam Antebi
    Nat. Commun. 
    8:16083 
    (2017)
    PMID: 28853436
  • Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense
    Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M Standley, Tamotsu Yoshimori, Masahiro Yamamoto
    Nat. Immunol. 
    18(8):899-910 
    (2017)
    PMID: 28604719
  • Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement
    Ikumi Hori, Takanobu Otomo, Mitsuko Nakashima, Fuyuki Miya, Yutaka Negishi, Hideaki Shiraishi, Yutaka Nonoda, Shinichi Magara, Jun Tohyama, Nobuhiko Okamoto, Takeshi Kumagai, Konomi Shimoda, Yoshiya Yukitake, Daigo Kajikawa, Tomohiro Morio, Ayako Hattori, Motoo Nakagawa, Naoki Ando, Ichizo Nishino, Mitsuhiro Kato, Tatsuhiko Tsunoda, Hirotomo Saitsu, Yonehiro Kanemura, Mami Yamasaki, Kenjiro Kosaki, Naomichi Matsumoto, Tamotsu Yoshimori, and Shinji Saitoh
    Sci Rep 
    7(1):3552 
    (2017)
    PMID: 28615637
  • Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules
    Atsushi Takahashi, Yoshitsugu Takabatake, Tomonori Kimura, Ikuko Maejima, Tomoko Namba, Takeshi Yamamoto, Jun Matsuda, Satoshi Minami, Jun-ya Kaimori, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Tamotsu Yoshimori and Yoshitaka Isaka
    Diabetes 
    66(5):1359-1372. 
    (2017)
    PMID: 28246295
  • A Structurally and Functionally Common Unit in Testes and Ovaries of Medaka
    Toshiya Nishimura, Shuhei Nakamura, Minoru Tanaka
    Sex. Dev. 
    10:159-165 
    (2016)
    PMID: 27410401
  • LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis
    Dan Wang, Lei Hou, Shuhei Nakamura, Ming Su, Fang Li, Weiyang Chen, Yizhen Yan, Christopher D. Green, Di Chen, Hong Zhang, Adam Antebi, Jing‐Dong J. Han
    Aging Cell 
    16(1):113-124 
    (2016)
    PMID: 27730721
  • Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes
    Shiou-Ling Lu, Tsuyoshi Kawabata, Yi-Lin Cheng, Hiroko Omori, Maho Hamasaki, Tatsuya Kusaba, Ryo Iwamoto, Hirokazu Arimoto, Takeshi Noda, Yee-Shin Lin, Tamotsu Yoshimori
    PLoS Pathog. 
    13(7):e1006444 
    (2017)
    PMID: 28683091
  • Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis.
    Hubber A, Kubori T, Coban C, Matsuzawa T, Ogawa M, Kawabata T, Yoshimori T, Nagai H
    Sci Rep 
    7:44795 
    (2017)
    PMID: 28317932
  • Intracellular fate of Ureaplasma parvum entrapped by host cellular autophagy.
    Nishiumi F, Ogawa M, Nakura Y, Hamada Y, Nakayama M, Mitobe J, Hiraide A, Sakai N, Takeuchi M, Yoshimori T, Yanagihara I
    MicrobiologyOpen 
     
    (2017)
    PMID: 28088841
  • Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms.
    Kondo H, Maksimova N, Otomo T, Kato H, Imai A, Asano Y, Kobayashi K, Nojima S, Nakaya A, Hamada Y, Irahara K, Gurinova E, Sukhomyasova A, Nogovicina A, Savvina M, Yoshimori T, Ozono K Sakai N
    Hum. Mol. Genet. 
    26(1):173-183 
    (2017)
    PMID: 28013294
  • New insights into autophagosome-lysosome fusion.
    Nakamura S, Yoshimori T
    J. Cell Sci. 
    130(7):1209-1216. 
    (2017)
    PMID: 28302910
  • Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome_lysosome fusion.
    Nakamura, S. Hasegawa, J. and Yoshimori, T
    Autophagy 
    12(12):2500-2501 
    (2016)
    PMID: 27715391
  • Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease.
    Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T
    Hepatology 
     
    (2016)
    PMID: 27637015
  • Atg9A Trafficking Through the Recycling Endosomes is Required for Autophagosome Formation.
    Imai K, Hao F, Fujita N, Tsuji Y, Oe Y, Araki Y, Hamasaki M, Noda T, Yoshimori T
    J. Cell Sci. 
     
    (2016)
    PMID: 27587839
  • Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome
    Hasegawa J, Iwamoto R, Otomo T, Nezu A, Hamasaki M, Yoshimori T
    Embo J. 
     
    (2016)
    PMID: 27340123